DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and sacm1lb

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001074093.2	Gene:	sacm1lb / 791142	ZFINID:	ZDB-GENE-070112-542	Length:	586	Species:	Danio rerio

Alignment Length:	524	Identity:	158/524 - (30%)
Similarity:	246/524 - (46%)	Gaps:	82/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AVALLTQQETDVIRKQY------TKVCDAYGCLGALQLNAGESTVLFLVLVTGCVSMG------- 89
            |:..::.:.|..:||..      ..:|   |.:|.::|.||    ::|:::|....:|
Zfish    31 AIDRVSTEMTLTVRKDVPPSAVTRPIC---GIMGTIRLVAG----VYLIVITKKKKVGDLLGHAV 88

  Fly    90 -KIGDIEIFRITQTTFVSLQN-AAPNEDKISEVRKLLNSGTFYFAHTNASASASGASSYRFDITL 152
             |..|.:|....:|......| ...|:..:|.:..:||:..||||..             :|:|.
Zfish    89 WKASDFDIISYKKTVLHLTDNQMQDNKVFLSMLNSVLNTDGFYFATD-------------YDLTH 140

  Fly   153 CAQRRQQT----------QETDNRFFWNRMMHIHLMRFGI---DCQSWLLQAMCGSVEVRTVYIG 204
            ..||...|          :..|.||.||.    ||:|..:   :...::...:.|.:.:|:..|.
Zfish   141 TLQRLSNTSPEFQEMTLLERADQRFVWNG----HLLREFMAQPELHRFVFPVIHGFIAMRSCCIN 201

  Fly   205 AKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQ- 268
            .|.....:|||.||.|||.|:.|||.:.||:.||||||||:|..:|...|::|||||:|.:|.|
Zfish   202 GKIFDWNLISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIIQYNGAKASFIQTRGSIPFYWSQR 266

  Fly   269 PGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRHH 333
            |.::. ..|.::|:.. .....|.||.......||.|.::|     ||..|..|..|...|.:..
Zfish   267 PNLKY-KPKPQISKSI-NHLDGFQRHFDSQIITYGKQVILN-----LVNQKGSEKPLEQAFAKMV 324

  Fly   334 GMSAHKDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHA-SNGQVLREQFGVVRTNCL 397
            |...:..:.::.||:|:||....:..|..|.:.:......:|.|.. |:|.|..:|.|..|:||:
Zfish   325 GSLGNGMIKYIAFDFHKECSRMRWHRLQILVDTVAELQDEFGYFLVDSDGSVQMQQDGTFRSNCM 389

  Fly   398 DCLDRTNCVQTYLGLDTLGIQLE---ALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYAGTGAI 459
            |||||||.:|:.|...:|..|||   .|.:|.:.:..:.||:|::..|.:|.|..:|.||||||:
Zfish   390 DCLDRTNVIQSLLARRSLQSQLERMAVLHVGQRIEEQADFEKIYKNAWADNANACAKQYAGTGAL 454

  Fly   460 -----QGGSK-----LMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNM 514
                 :.|.:     ||||..|..|..:||..|..:|::||:.|  ...:.|.||.      :..
Zfish   455 KTDFTRTGKRTQWGLLMDGWNSMIRYYKNNFSDGFRQDSIDLFL--GNYAVEEADM------NTP 511

  Fly   515 LHAP 518
            ||.|
Zfish   512 LHEP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	92/314 (29%)
		INPP5c_Synj	538..863	CDD:197323
		DUF1866	862..1008	CDD:286093
sacm1lb	NP_001074093.2	COG5329	56..526	CDD:227637	154/499 (31%)
sacm1lb	NP_001074093.2	Essential for phosphatidylinositol-4-phosphate phosphatase activity. /evidence=ECO:0000250\|UniProtKB:Q9NTJ5	451..586		23/73 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920