DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and ocrl

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_009289414.1	Gene:	ocrl / 777716	ZFINID:	ZDB-GENE-061110-61	Length:	961	Species:	Danio rerio

Alignment Length:	552	Identity:	168/552 - (30%)
Similarity:	263/552 - (47%)	Gaps:	98/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 QGGSKLMDGARSAAR--TIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVL 522
            :|.:..:.|..:..|  ::||.....::.:::|    .|...||....:.|.......||.:
Zfish   223 KGTNTSLTGPATKERPPSVQNATPVRNEFQSVD----RSVSWSESPSNSTIRQAMMSSHAGS--- 280

  Fly   523 RE------LCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDV 581
            ||      |.|:..|||..:..:..|||:||||...      ..||..||
Zfish   281 REGLLKYRLSKKEKEYVDIKNFKFFVGTWNVNGQSP------DSSLGPWL--------------- 324

  Fly   582 NNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGV 646
               |.:.| |.|:||:||:|: ||:........:...:||.:.:::.:.:...|:.:...:|||:
Zfish   325 ---SSDPD-PPDVYALGFQEL-DLSTEAFFYMDSSKEQLWVDAVERGLHQKARYIQVRIIRLVGM 384

  Fly   647 CLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERN 711
            .|.:||:.||...||::|.:.|.|||....||||..|:|||.|.||.|||.:|.||.......||
Zfish   385 MLVVYIKKEHKDQIREIASESVGTGLMNKMGNKGGVAVRFVFHNTSFCFVNSHLAAHVDDFERRN 449

  Fly   712 ADYAEITRKLAF------PMGRTLKSHDWVFWCGDFNYRIDM-EKDELKECVRNGDLSTVLEFDQ 769
            .||.:|..:::|      |:  ::..||.|.|.||.|||:.: :..|:|..:...:|..:.|:||
Zfish   450 QDYKDICARMSFHLLEYPPV--SIVKHDVVIWLGDLNYRLCLPDAGEVKRLIAEKELRRLQEYDQ 512

  Fly   770 LRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAAS 834
            |..:::...||.:|:||||.|.||||||..||.:|:|.|.|.|||.||:|||....
Zfish   513 LNLQRKTKRVFTDFMEGEINFIPTYKYDAKSDRWDSSGKCRIPAWCDRILWRGSNV--------- 568

  Fly   835 AWNPGKLIHY-GRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHVLES 898
                 |.:|| ...|||.|||:||.::....:..:.:||.:.:||:::||:...::..:..:
Zfish   569 -----KQLHYRSHMELKTSDHKPVSSVFSIGVKMVIEQRYKKIFEEIVRDMDRMENDFLPSL--- 625

  Fly   899 SATGDEDGPTIYDENV-------MSALITELSKMGEV----TLVRYVEDTM----WVTFRDGESA 948
            |.|..|    ...|||       .|.|||   ..|:|    ..:..:.|:.    |:.....|..
Zfish   626 SLTRRE----FTFENVKFRQLQRQSFLIT---NDGQVACTFAFIPKLNDSQYCKPWLRAEPCEGV 683

  Fly   949 LNASSKKSIQVCGLDLILEL-KSKDWQHLVDS 979
            |:.:.|       :::.||: .|||...|::|
Zfish   684 LDPNEK-------IEIFLEVYVSKDSVTLLNS 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	119/332 (36%)
		DUF1866	862..1008	CDD:286093	30/134 (22%)
ocrl	XP_009289414.1	PH_OCRL1	13..122	CDD:270182
		INPP5c_INPP5B	302..593	CDD:197327	119/332 (36%)
		RhoGAP_OCRL1	728..956	CDD:239845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740