Protein Alignment Synj and Inppl1

DIOPT Version :10

• Sequence 1: NP_569729.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_075233.1
• Gene: Inppl1 / 65038
• RGDID: 68396
• Length: 1257
• Species: Rattus norvegicus
• Alignment Length: 864
• Identity: 204/864 - (23%)
• Similarity: 315/864 - (36%)
• Gaps: 255/864 - (29%)

  Fly   473 ARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRAR----ILLPSNMLHAPTTVLRELCKRYTEYV 533
            ::.:||.|              |.....| .||.:    |.:.:....|...:|:.:..::::..
  Rat   371 SQRVQNKL--------------GVVFEKE-KDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQD 420

  Fly   534 RPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIG 598
            .|.|..|.:||:|:.      |:....::..|..   :....|||.:|     .|..|.|||..|
  Rat   421 EPDMISVFIGTWNMG------SVPPPKNVTSWFT---SKGLGKALDEV-----TVTIPHDIYVFG 471

  Fly   599 FEEIVDLNASNIMAASTDNAKLWAEELQKTISR--DNDYVLLTYQQLVGVCLYIYIRPEHAPHIR 661
            .:|            ::...:.|.:.|:..:..  |.||..:..|.|..:.:.:.::|||...|.
  Rat   472 TQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRIS 524

  Fly   662 DVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMG 726
            .|:...||||:....|||||..:.|:.:|||..||..|..:|..:...||.:|.:|.|.|:  :|
  Rat   525 HVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDILRLLS--LG 587

  Fly   727 -RTLKSHD------WVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFL 784
             |.|.:.|      .:||.||.|||:||:..|:...:...:...:|..|||..|:|...||..|.
  Rat   588 DRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPLLRVDQLNLEREKHKVFLRFS 652

  Fly   785 EGEITFDPTYKYDLFSDDYDTSEKQR-------APAWTDRVLWRRRKALAEGDFAASAWNPGKLI 842
            |.||:|.|||:|:..|.|.....||:       .|:|.||:||   |:..|.....::
  Rat   653 EEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILW---KSYPETHIICNS------- 707

  Fly   843 HYG-RSELKQSDHRPVI-----------------------AIIDAEIME-IDQQRRRAVF----- 877
             || ..::..|||.||.                       |.|:.|.:| |.:...|..|
  Rat   708 -YGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFY 771

  Fly   878 --------EQVIRDLGPPDSTIVVHVLESS-----------------------ATGDEDGPTIYD 911
                    :....|....|:...:.|..||                       .....||...|.
  Rat   772 STCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYG 836

  Fly   912 ENVMS----------ALITELSKMGEVT-------LVRYVEDTM--------WVTFRDGESALNA 951
            |.|::          ..:|.||..||.|       .||...:.:        |::....::  .|
  Rat   837 ECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDT--GA 899

  Fly   952 SSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQLLQAITPELPQRPKQP 1016
            .||....:.|          ..:|...|.....|..:.||               .:|.:.|::|
  Rat   900 KSKAPSVLRG----------SQEHRSGSRKPTSTEASCPL---------------SKLFEEPEKP 939

  Fly  1017 PTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMPPQPQSQPLIPSPLQPQVAPPRPPAMD 1081
            |  |..|||.|      ||.:|.           :..:.|:.:|:   .:|.|..||.|.|....
  Rat   940 P--PTGRPPAP------PRAVPR-----------EESLNPRLKSE---GTPEQEGVAAPPPKNSF 982

  Fly  1082 TTPS--SKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPTRQVGSPK 1144
            ..|:  .....|.:|:             |..|...:..|.||   .:|....::.|..|:|..:
  Rat   983 NNPAYYVLEGVPHQLL-------------PLEPTSFARAPIPP---TTKNKVAITVPAPQLGRHR 1031

  Fly  1145 DPIPSDTAYETASNIYEEIQEDVPAPRHPPPAGP------PP-------------VIGAPMGPPP 1190
            .|...:     .|:..|:....:|.|..|||..|      ||             .:|...||||
  Rat  1032 TPRVGE-----GSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSVGEARGPPP 1091

  Fly  1191 PLPNRRGPPPIPNRSGNAP 1209
            |..:.|  ||:|  .|.:|
  Rat  1092 PKAHPR--PPLP--PGTSP 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_569729.1	COG5329	61..493	CDD:227637	3/19 (16%)
		INPP5c_Synj	538..863	CDD:197323	104/364 (29%)
		DUF1866	862..1008	CDD:286093	33/207 (16%)
Inppl1	NP_075233.1	SH2_SHIP	17..119	CDD:198206
		PHA03247	<103..175	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	102/341 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	897..986		29/137 (21%)
		SH3-binding	945..950		3/10 (30%)
		NPXY motif	984..987		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1004..1115		30/115 (26%)
		SAM_Ship2	1193..1255	CDD:188890