DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and inpp5b

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_009290335.3	Gene:	inpp5b / 563543	ZFINID:	ZDB-GENE-110411-228	Length:	907	Species:	Danio rerio

Alignment Length:	694	Identity:	183/694 - (26%)
Similarity:	285/694 - (41%)	Gaps:	179/694 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 WINNGNEVSKIYAGTGAIQGGSKLMDGARSAARTI--------------QNNLLDNSKQEAIDVL 492
            |:....:|||                ||||..::|              :.:..::|..:..|..
Zfish   140 WLTKYRKVSK----------------GARSLRKSIGATTVKMSQMKKAERAHTANSSALKKEDES 188

  Fly   493 LVGSTLSSE------------------LADRARIL------LPSNMLHAPTTVLRELCKRYTEYV 533
            ..|..|.|:                  |:::|::|      |..|::..      ||.|....|.
Zfish   189 ARGDALQSQEKVKGEVKDDLIRNSQPVLSNKAQMLGMPQFGLRDNLIKC------ELLKNEDAYT 247

  Fly   534 RPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIG 598
            ........:|||||||...      |:||:.||                   .:...|.|.|.||
Zfish   248 YIENYSFFLGTYNVNGQTP------KESLSPWL-------------------ASTASPPDFYLIG 287

  Fly   599 FEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDV 663
            |:|: ||:....:...|.....|...:.|.:..|..|.|:...:|||:.|..|::.||||||.:|
Zfish   288 FQEL-DLSKEAFLFNDTPKEPEWMLAVYKGLHPDAKYALVKLVRLVGIMLLFYVKAEHAPHISEV 351

  Fly   664 AIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAF----- 723
            ..:.|.||:.|..|||||.:|||..|.:.:|.|.:|.||...:...||.|:.:|.|::.|
Zfish   352 EAETVGTGVMGRMGNKGAVSIRFQFHNSDICVVNSHLAAHTEEFERRNQDFKDICRRIQFRQEDP 416

  Fly   724 ---PMGRTLKSHDWVFWCGDFNYRI-DMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFL 784
               |:  |:..|:.|.|.||.|||| |:|.|.:|:.:...|..|:..:|||:::.:...||..|.
Zfish   417 TLPPL--TILKHNIVLWLGDLNYRISDLEVDHVKDLISKKDFETLHTYDQLKRQMDEEVVFVGFT 479

  Fly   785 EGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHY-GRSE 848
            ||||.|.||||||..||.:|||||.|.|||.||:|||.:..              |.:|| ....
Zfish   480 EGEIDFQPTYKYDTGSDQWDTSEKCRVPAWCDRILWRGKSI--------------KQLHYQSHMT 530

  Fly   849 LKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPDSTIV--------------VHVLESS 899
            ||.|||:||.::::..|..::::..:..||:::|.:...::..:              |..::..
Zfish   531 LKTSDHKPVSSLLEIGIKVVNEESYKRTFEEIVRQIDRLENDCIPSVSLSEREFHFQDVKFMQHQ 595

  Fly   900 ATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESALNASSKKSIQV----- 959
            |.    ..|::::..:......:.|:.|....:     .|:|....:..|...:...|.:
Zfish   596 AR----TVTVHNDGQVPCQFEFIQKLDEPAYCK-----PWLTANPAKGFLAQGASVDIDLEVFVN 651

  Fly   960 --------CGLD-----LILEL-KSKDWQHLVDSEIELCTTNTIPLCANPVEHAQLLQAITPELP 1010
                    .||.     |:|.| :.||:...:       |.:.:|.|......|..|.
Zfish   652 RHTAPELNAGLQQLEDILVLHLERGKDYFISI-------TGSYLPSCFGSSLSALCLL------- 702

  Fly  1011 QRPKQPPTRPPARPPMPMSPK-NSPRHLPHVGVISIVPKPAKPP 1053
               ::|....|......:|.| |||       ||....||.:.|
Zfish   703 ---REPIQDMPLESIRELSVKSNSP-------VIDSADKPQEIP 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	123/334 (37%)
		DUF1866	862..1008	CDD:286093	25/178 (14%)
inpp5b	XP_009290335.3	INPP5B_PH	6..146	CDD:318889	1/5 (20%)
		INPP5c_INPP5B	253..545	CDD:197327	123/333 (37%)
		PapD-like	574..>648	CDD:317302	9/82 (11%)
		RhoGAP_OCRL1	680..892	CDD:239845	17/81 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910