Protein Alignment Synj and inpp5d

DIOPT Version :10

• Sequence 1: NP_569729.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_021329769.1
• Gene: inpp5d / 559103
• ZFINID: ZDB-GENE-100922-30
• Length: 1108
• Species: Danio rerio
• Alignment Length: 1035
• Identity: 222/1035 - (21%)
• Similarity: 358/1035 - (34%)
• Gaps: 351/1035 - (33%)

  Fly   336 SAHKDVPHVVFDYHQECRGGN---------FSALAKLKERIVACGANYGVFHASNGQVLREQFG- 390
            :.::.:||........|:..|         |.||.|:.::.::.||..          ||.|..
Zfish   196 NGNQTLPHFKKLTQNICKNLNSEIARTLPSFEALQKVLDQPLSPGAGR----------LRTQLSA 250

  Fly   391 ------VVRTNCLDCL-----DRT-NCVQTYLGLDTLGIQLEALKMGGKQQNI---SRFEEIFRQ 440
                  ..|...|..|     |:| |.|..::|.|           ||.:.::   ..||.....
Zfish   251 DANPSVAFRLEQLTKLIQSIEDKTKNAVFEFVGYD-----------GGHRNSLIPPVTFEVKSDS 304

  Fly   441 MWINNGNEVSKIYAGTGAIQGG----SKLMDGARSAARTIQNNLLDNSKQEAID--VLLVGSTLS 499
            :.|:|     |:|.... ::||    .|..||... ...:.|.:|...|.:.:.  ::||..|..
Zfish   305 LGISN-----KMYLKVD-VEGGKVYFKKSKDGPED-KYFVHNKILQLVKSQKMHNRLVLVVETEK 362

  Fly   500 SELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLAD 564
            .:...:..:...:........:|:::..:::....|.|..:.|||:|:.....      ..::..
Zfish   363 GKTQSKDFVFDDTKKREGFCQLLQQMKNKHSGKPEPDMITIFVGTWNMGNANP------PQNITS 421

  Fly   565 WLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTI 629
            |.       :||.....::.:.| ..|.|||.||.:|            .....|.|.|.::..:
Zfish   422 WF-------QSKGQGKTHDDTAN-QIPHDIYVIGTQE------------DPLGEKEWIETIRGAL 466

  Fly   630 SRDNDYVLLTYQQLV-----GVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLH 689
               .|...::::|:.     .:.:.:..:|||......:..|.||||:..|.|||||..:.|:.:
Zfish   467 ---RDITNISFKQIATQTLWSIRIVVLAKPEHENRFSHIFSDSVKTGIANALGNKGAVGVSFMFN 528

  Fly   690 GTSMCFVCAHFAAGQSQVAERNADYAEITR------KLAFPMGRTLK-SHDWVFWCGDFNYRIDM 747
            .||..||.:|..:|..:...||.:|..|.|      |...|...|.: :|  :||.||.|||:|:
Zfish   529 RTSFGFVNSHLTSGSEKKLRRNQNYVSILRFLNLGDKKVNPFDITHRFTH--LFWLGDLNYRVDL 591

  Fly   748 EKDELKECV---RNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYD-------LFSDD 802
            ...|.:..|   :......:|..|||:.|::...||.|::|.||||.|||:::       .::..
Zfish   592 PSHEAENIVMKIKQQQYKELLAQDQLKIEKDEEKVFLEYVEEEITFAPTYRFERDTRERYAYTKA 656

  Fly   803 YDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIH-----YG-RSELKQSDHRPVIAII 861
            ..|..|...|:|.||||   ||:.             .|:|     || .:::..|||.||.|..
Zfish   657 KATGTKYNLPSWCDRVL---RKSY-------------PLVHVVCNSYGCTNDIMTSDHSPVFATF 705

  Fly   862 DAEIM-------EIDQQRRRAV-------------------------FEQVIR------------ 882
            |..:.       ::....|.|:                         .|:.:|
Zfish   706 DVGVTSQFVSKNDLSNDARGAIKILNCVAVLCTKSKTKFFIEYHSSCLEKFVRSPDGENQEMEGS 770

  Fly   883 ---------DLGP----PDSTIVVHVLESSATGDEDGPTIYDENVMS-----ALITELSKMGEVT 929
                     :|.|    |:..:..|:|....:.|.|  ..|.|..::     :..||.|    :|
Zfish   771 IKVRFAGQVELTPIIADPEYLLDQHILICIKSTDSD--ESYGEGCVALRSAESSYTEFS----IT 829

  Fly   930 LVRYVEDTMWVT------------------------------FRDGESALNASS----------- 953
            |..:.|.|.|:|                              .:.|::...:||
Zfish   830 LTHHGERTGWLTGAIQLPKSEGKQTEKLYDFIKVGDDPGAGKGKTGDNTKMSSSVLASDISNPSY 894

  Fly   954 -----KKSIQVCG----------LDLI---LELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQ 1000
                 |..||..|          .|:.   :..|...:.|...|.... |:|.||:...|
Zfish   895 MGVGYKSGIQAPGSLTSQRTGPSKDMTHGNISPKKTSYDHATSSPTAK-TSNPIPVDGQP----- 953

  Fly  1001 LLQAITPELPQRPKQPPTRPPARPPMPMS-PKNSPRHLPHVGVISIVPKPA------KPPMP--- 1055
                  ||:...|...          .|| .:.:..|.|....:...|||.      :||:|
Zfish   954 ------PEMFDNPLYG----------SMSGSRGAKEHHPPPDALFAFPKPTDFDSDRQPPVPTPR 1002

  Fly  1056 ----------PQ-------------PQS---QPLIPSPLQ-PQVAPPRPPAMDTTPSSKSQSPTE 1093
                      ||             |||   :|::||..: ..:.|.|||.           |.:
Zfish  1003 LRSYTCSETKPQSSSSTNLNMSSLLPQSITKKPVVPSRSEGGMIGPNRPPV-----------PMK 1056

  Fly  1094 LVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATP--VSTPTRQVGSPKDPIPSDT 1151
                    |.||:|..        |.|.||..:.....|  :..||| .|..|| :.|:|
Zfish  1057 --------SRSGQTQE--------PQTKPRDYRDSSELPSKIRPPTR-AGQTKD-VHSET 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_569729.1	COG5329	61..493	CDD:227637	38/187 (20%)
		INPP5c_Synj	538..863	CDD:197323	96/352 (27%)
		DUF1866	862..1008	CDD:286093	39/266 (15%)
inpp5d	XP_021329769.1	SH2_SHIP	3..105	CDD:198206
		EEP	401..707	CDD:469791	96/352 (27%)
		PHA03378	<935..>1088	CDD:223065	44/202 (22%)