DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Inpp5d

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_062184.2	Gene:	Inpp5d / 54259	RGDID:	2914	Length:	1190	Species:	Rattus norvegicus

Alignment Length:	832	Identity:	199/832 - (23%)
Similarity:	310/832 - (37%)	Gaps:	235/832 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 VLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPS 585
            :|:::..:::|...|.|..:.:||:|:......:.|      ..|.|       ||.  ......
  Rat   389 LLQQMKNKHSEQSEPDMITIFIGTWNMGNAPPPKKI------TSWFL-------SKG--QGKTRD 438

  Fly   586 ENVDH-PVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLT--YQQLVGVC 647
            ::.|: |.|||.||.:|            .....|.|.|.|:.::.........|  ...|..:.
  Rat   439 DSADYIPHDIYVIGTQE------------DPLGEKEWLEILRHSLQEVTSMTFKTVAIHTLWNIR 491

  Fly   648 LYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNA 712
            :.:..:|||...|..:..|.||||:....|||||..:.|:.:|||:.||.:|..:|..:...||.
  Rat   492 IVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQ 556

  Fly   713 DYAEITRKLAF------PMGRTLK-SHDWVFWCGDFNYRIDM---EKDELKECVRNGDLSTVLEF 767
            :|..|.|.||.      |...|.: :|  :||.||.|||:::   |.:.:.:.::....|.:|..
  Rat   557 NYMNILRFLALGDKKLSPFNITHRFTH--LFWLGDLNYRVELPTWEAEAIIQKIKQQQYSDLLAH 619

  Fly   768 DQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRA-------PAWTDRVLWRRRKA 825
            |||..|::...||..|.|.||||.|||:::..:.|.....||:|       |:|.|||||:..
  Rat   620 DQLLLERKEQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSY-- 682

  Fly   826 LAEGDFAASAWNPGKLIH-----YG-RSELKQSDHRPVIAIIDAEIME----------IDQQ--- 871
                          .|:|     || .|::..|||.||.|..:|.:..          :|.|
  Rat   683 --------------PLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGAVDSQGQI 733

  Fly   872 -----------RRRAVF--------------------------EQVIR------DLGP----PDS 889
                       :.:..|                          |.|:|      .|.|    |:.
  Rat   734 EFLACYATLKTKSQTKFYLELHSSCLESFVKSQEGENEEGDEGELVVRFGETLPKLKPIISDPEY 798

  Fly   890 TIVVHVLESSATGDEDGPTIYDENVMS----------ALITELSKMGEVTLVRYVEDTMWVTFRD 944
            .:..|:|.|..:.|.|  ..|.|..::          .:.|.|:..||:|          ..||
  Rat   799 LLDQHILISIKSSDSD--ESYGEGCIALRLETTESQLPIYTPLTHHGEMT----------GHFR- 850

  Fly   945 GESALNASSKK------------SIQVCGLDLILELKSKD----WQHL-------VDSEIELCTT 986
            ||..|..|..|            ..:..|:..:..|.|.|    |:..       :.|..|:...
  Rat   851 GEIKLQTSEGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPAGRVPACGISSLNEIINP 915

  Fly   987 NTIPL--CANPVEHAQLL---QAIT----PELPQ-------RPKQPPTRPPARPPMPMSPK---- 1031
            |.|.:  ...|:.....|   |.:|    .:||:       |.:.||| ||::|  |:|||
  Rat   916 NYIGMGPFGQPLHGKSTLSPDQQLTAWSYDQLPKDSSLGPGRGEGPPT-PPSQP--PLSPKKFSS 977

  Fly  1032 ------NSPR----HLPHVGVISIVPKPAKPPMPPQPQSQPLIPS--------PLQPQVAPPR-- 1076
                  :.||    ....:|.:..:|:...|...|:....||..|        |.:.|.:|..
  Rat   978 STANRGSCPRVQETRPGDLGKVEALPQEDLPLTKPEMFENPLYGSVSPFPKLVPRKEQESPKMMR 1042

  Fly  1077 ---PPAMDTTPSSKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPT- 1137
               ||..|...|    ||:.::..:....:...||..||..:.||....|......:.....|:
  Rat  1043 KEPPPCPDPGVS----SPSIMLPKAQEVENVKGTSKQAPVPVFGPTPRIRSFTCSSSAEGRMPSG 1103

  Fly  1138 -RQVGSPK------DPIPSDTAYETASNIYEEIQEDVPAPRHPPPAGPPPVI 1182
             :..|.||      .|:|.....:.:.:...:....:||||.|.|...|.|:
  Rat  1104 DKSQGKPKAPASSQAPVPVKRPVKPSRSEMSQQTTPIPAPRPPLPVKSPAVL 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	101/350 (29%)
		DUF1866	862..1008	CDD:286093	42/247 (17%)
Inpp5d	NP_062184.2	SH2_SHIP	4..105	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..130
		SH3-binding 1	126..131
		INPP5c_SHIP1-INPP5D	406..712	CDD:197334	101/350 (29%)
		NPXY motif 1	914..917		0/2 (0%)
		PTZ00449	<930..>1132	CDD:185628	47/208 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..1190		52/217 (24%)
		SH3-binding 2	969..974		3/4 (75%)
		Interaction with DAB2. /evidence=ECO:0000250	1014..1028		3/13 (23%)
		NPXY motif 2	1017..1020		1/2 (50%)
		SH3-binding 3	1038..1049		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740