DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and Sh2d1a

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001102783.2	Gene:	Sh2d1a / 501502	RGDID:	1562408	Length:	126	Species:	Rattus norvegicus

Alignment Length:	119	Identity:	28/119 - (23%)
Similarity:	47/119 - (39%)	Gaps:	21/119 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VIRKQYTKVCDAYGCLGALQLNAGESTVLFLVLVTG--CVSMGKIGDIEIFRITQTTFVSLQ-NA 110
            :.|:...|:..|.|..|:..|...||       |.|  |:.:...|.|..:|::||...|.. ..
  Rat    11 ISREMGEKLLLATGLDGSYLLRDSES-------VPGVYCLCVLYQGYIYTYRVSQTETGSWSAET 68

  Fly   111 APNEDK--ISEVRKLLNS---------GTFYFAHTNASASASGASSYRFDITLC 153
            ||...|  ..:|:.|:::         ....:....:||.:..|.:.|.|..:|
  Rat    69 APGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSARSPQAPTGRRDSDIC 122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	25/107 (23%)
		INPP5c_Synj	538..863	CDD:197323
		DUF1866	862..1008	CDD:286093
Sh2d1a	NP_001102783.2	SH2_SAP1a	2..104	CDD:198263	22/99 (22%)
		Interaction with FYN SH3 domain. /evidence=ECO:0000250\|UniProtKB:O88890	67..92		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..126		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830