DRSC/TRiP Functional Genomics Resources

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Protein Alignment Synj and OCRL

DIOPT Version :9

Sequence 1:NP_001246454.1 Gene:Synj / 37517 FlyBaseID:FBgn0034691 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_001305713.1 Gene:OCRL / 4952 HGNCID:8108 Length:902 Species:Homo sapiens


Alignment Length:586 Identity:166/586 - (28%)
Similarity:259/586 - (44%) Gaps:124/586 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 RGGNFSALAKLKER------IVACGANYGVFH----------ASN-GQVLREQFGVVRTNCLDCL 400
            |.|.:..:.:|.|:      |:...:::....          ||| |..:|.|...:|....:..
Human    36 RNGQYELIIQLHEKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIP 100

  Fly   401 DRTNCVQTYLGLDTLGIQLEALKMGGKQQNISR-------------------FEEIFRQM----W 442
            |..:|:: :|.......:.::..:..:|::.|.                   ||:.|..|    .
Human   101 DEEHCLK-FLSAVLAAQKAQSQLLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKK 164

  Fly   443 INNGNEVSKIYAGTGAIQ-GGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRA 506
            ||:.|:.:.|:....... ..:|::...:.|:...|..:.:..::     |.|.:|.|.:     
Human   165 INSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMRK-----LFVPNTQSGQ----- 219

  Fly   507 RILLPSNMLHAPTTVLRE------LCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDS-LAD 564
                            ||      |.||..|||..:..|..|||:||||..       .|| |..
Human   220 ----------------REGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQS-------PDSGLEP 261

  Fly   565 WLLDCHALARSKALVDVNNPSENVD-HPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKT 628
            ||                    |.| :|.|||.|||:|: ||:........:...:.|:..:::.
Human   262 WL--------------------NCDPNPPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERG 305

  Fly   629 ISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSM 693
            :.....|..:...:|||:.|.|:.|.:...:|||:|.:.|.||:.|..||||..|:|||.|.|:.
Human   306 LHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTF 370

  Fly   694 CFVCAHFAAGQSQVAERNADYAEITRKLAFPM-GRTL-----KSHDWVFWCGDFNYRIDM-EKDE 751
            |.|.:|.||.......||.||.:|..:::|.: .:||     ..|:.|.|.||.|||:.| :.:|
Human   371 CIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANE 435

  Fly   752 LKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTD 816
            :|..:...||..:|:||||..::.....|.:|.||||.|.||||||..:|.:|:|.|.|.|||.|
Human   436 VKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCD 500

  Fly   817 RVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVI 881
            |:|||             ..|..:|.:....|||.|||:||.|:....:..:|::|.|.|||..:
Human   501 RILWR-------------GTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSV 552

  Fly   882 R 882
            |
Human   553 R 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynjNP_001246454.1 Syja_N 61..353 CDD:280532 166/586 (28%)
INPP5c_Synj 538..863 CDD:197323 119/333 (36%)
DUF1866 862..1008 CDD:286093 7/21 (33%)
OCRLNP_001305713.1 PH_OCRL1 15..116 CDD:270182 15/80 (19%)
Clathrin box 1 74..78 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..188 4/22 (18%)
5-phosphatase 238..564 126/357 (35%)
INPP5c_INPP5B 241..534 CDD:197327 119/333 (36%)
ASH 565..679
RhoGAP_OCRL1 669..897 CDD:239845
Clathrin box 2 703..707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146123
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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