DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Sac1

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	153/517 - (29%)
Similarity:	245/517 - (47%)	Gaps:	75/517 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SPHSVLLEHRNKSDSILFESHAVALLTQQETDVI---RKQYTKVCDAYGCLGALQLNAGESTVLF 78
            :|.|.::|.....:.::...|......|..:..:   .:...::|   |.||.:.|.:.:    :
  Fly    18 APQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANLRPTRRIC---GVLGTIHLLSCD----Y 75

  Fly    79 LVLVTGCVSMGKIGDIEIFRITQTTFV-----SLQNAAPNEDKISEVRKLLNSGTFYFAHTNASA 138
            |::.|..:.:|.:....::|:.....:     |.|. ..||:.:..:|:.|::..|||
  Fly    76 LLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQR-KENENYLRLLRQTLDTKFFYF------- 132

  Fly   139 SASGASSYRFDITLCAQRRQQT-----------QETDNRFFWNRMMHIHLMRFGID-CQSWLLQA 191
                  |||:|:|...||:::.           |..:.||.||..:   |.:|..| .:.:.|..
  Fly   133 ------SYRYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYV---LRQFNCDKMEKFQLPL 188

  Fly   192 MCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYV 256
            :.|.|.:..|.|..:....:||:|.|.:|||||...||::::|:|||||||||::..:|.:|.:|
  Fly   189 VLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTGFV 253

  Fly   257 QTRGSVPLFWEQ-PGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKE 320
            |||||:|..|.| |.::.....| |..| :...||...|.....:.||....||     ||..|.
  Fly   254 QTRGSMPFHWHQLPNLRYKPRPV-LVPG-KDHLAACGLHFKEQIRLYGNNVAVN-----LVDHKG 311

  Fly   321 GEAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHA-SNGQV 384
            .|..|...:.|......:..|.:..||:|.|||...:..|..|.:|:......:||:|. .:|::
  Fly   312 AEGELEATYARLVREMGNPQVRYESFDFHSECRKMRWDRLNILIDRLAHEQDQFGVYHVFDDGKL 376

  Fly   385 LREQFGVVRTNCLDCLDRTNCVQTYLG-------LDTLGIQLEALKMGGKQQNISR-FEEIFRQM 441
            :..|.||.||||:|||||||.||:.|.       |..||:    |.:|.|.::.|. ||.||:.:
  Fly   377 VSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGV----LHVGQKVEHASDIFESIFKGV 437

  Fly   442 WINNGNEVSKIYAGTGAIQ----------GGSKLMDGARSAARTIQNNLLDNSKQEAIDVLL 493
            |.:|.:.||..|:||.|::          ....:.||..|..|...||..|..:|::||:.|
  Fly   438 WADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	91/309 (29%)
		INPP5c_Synj	538..863	CDD:197323
		DUF1866	862..1008	CDD:286093
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	153/517 (30%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	92/312 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26060at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850