DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and inppl1b

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001034224.2	Gene:	inppl1b / 368433	ZFINID:	ZDB-GENE-030616-75	Length:	1226	Species:	Danio rerio

Alignment Length:	806	Identity:	189/806 - (23%)
Similarity:	291/806 - (36%)	Gaps:	261/806 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 VAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDH-PVDIYAIGFEEIV 603
            |.|||:|:.|...      ..||..| :.|..|..:        |.|::.. |.||||:|.::
Zfish   406 VFVGTWNMGGTPP------PGSLQSW-VTCSGLGLT--------PDESISSLPHDIYAVGTQD-- 453

  Fly   604 DLNASNIMAASTDNAKLWAEELQKTI--SRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAID 666
                      :....:.|||.::.|:  |.:.||..:..|.|..:.|.::::|||...|..|...
Zfish   454 ----------NPQGEREWAEHIRATLRTSTNIDYKQVAVQSLWNIRLAVFVKPEHEARISQVNTA 508

  Fly   667 CVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMG-RTLK 730
            .||||||...|||||..:..:.:||||.||..|..:|..:...||.::.:|.|.|:  :| :.|.
Zfish   509 SVKTGLGNTLGNKGAVGVSLLFNGTSMGFVNCHLTSGSDKALRRNHNFQDILRLLS--LGEKQLS 571

  Fly   731 SHD------WVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEIT 789
            :.|      .:|||||.|||:|::..::.:.|...:...::..|||.:|:.....|..|.|.:|.
Zfish   572 TFDISLRFNHLFWCGDLNYRLDLDALDILKHVSKREFEELMCADQLTRERHKRKAFFNFKEEKIM 636

  Fly   790 FDPTYKYDLFSDD------YDTSEKQ-RAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHYG-R 846
            |.|||:|:..|.|      |.:|..| ..|:|.|||||   |:..|.....::        || .
Zfish   637 FPPTYRYERGSRDCYLWQKYKSSGVQVNGPSWCDRVLW---KSYPESHVICTS--------YGCT 690

  Fly   847 SELKQSDHRPVIAIIDAEIMEI----DQQRRRAVFEQVIRDLGPPDSTIVVHVLESSATGDEDGP 907
            .::..|:|.||.|..:..::.:    :....||..|                 ||:
Zfish   691 DDIFTSEHSPVFATFEVGVISLFPRTESCSERASIE-----------------LEA--------- 729

  Fly   908 TIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRD------GESALNASSKKSIQVCGLDLIL 966
                   :.|::...||.           ..::.|..      ..||.|.|     |.|.:...|
Zfish   730 -------IEAIVKTSSKA-----------KFFIEFHSRCLEEPRRSAENDS-----QYCEVPGFL 771

  Fly   967 EL--KSK----------DWQHLVDSEIELCTTNTIPLCANPVEHAQLLQAITPE----------- 1008
            :|  .||          |.:||.|..:.|    ::..|.....:.:...|:.|.
Zfish   772 KLGWSSKQLPKLHPVFLDLEHLRDQHLLL----SVKSCDGFESYGECCVALRPTAGKLLDTFETC 832

  Fly  1009 LPQRPKQ------------PPTRPPARPPM------------PMSPKNSPRHLPHVGVISIVPKP 1049
            |..|.::            ||.|...|..:            .|..:.||   |.....||....
Zfish   833 LTHRGEEMGSIRGRFRVYVPPDRRRIRERVYEWLSIEKDEREMMKDQLSP---PSSSAFSIKAPS 894

  Fly  1050 AKPPMPPQPQSQPL---------------IPSPLQPQ---------VAPPRPPA----------- 1079
            |.....|...:.|.               |||.::..         :..||...
Zfish   895 ASYVASPNSYTNPAYFIFEEMPVFRKAEEIPSTIKESQVVCANNTVIQLPRVTGSHGHGKRSARR 959

  Fly  1080 MDTT------------PSSKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATP 1132
            .|.|            ||.::||  ||    |||:||.:..|       ||..|......:..|.
Zfish   960 SDFTEIEIPGSLAPYKPSCETQS--EL----SSTASSYQLFP-------GPHVPSTSPNQRHTTH 1011

  Fly  1133 VSTPTRQVGSPKDPIPSDT--AYETASNIY------------EEIQEDVPAPRHPPPAGPPPVIG 1183
            .|..:.|:.|.|:.:..|:  :.:..:|.|            |::::|..              |
Zfish  1012 SSNSSLQLQSHKNNMAPDSELSGKKLTNSYMNHSVFSRDMHKEKVRQDYQ--------------G 1062

  Fly  1184 APMGPPPPLPNRRGPPPIPNRSGNAP 1209
            ...|.|.|:  |.||...|..|...|
Zfish  1063 VHQGRPVPI--RNGPKLYPYVSTRVP 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	105/340 (31%)
		DUF1866	862..1008	CDD:286093	26/167 (16%)
inppl1b	NP_001034224.2	SH2_SHIP	2..104	CDD:198206
		EEP	404..707	CDD:294334	105/340 (31%)
		SAM_superfamily	1165..1221	CDD:301707
		SAM	1165..1218	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840