DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and INPPL1

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_024304269.1	Gene:	INPPL1 / 3636	HGNCID:	6080	Length:	1324	Species:	Homo sapiens

Alignment Length:	881	Identity:	213/881 - (24%)
Similarity:	326/881 - (37%)	Gaps:	239/881 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 ARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRAR----ILLPSNMLHAPTTVLRELCKRYTEYV 533
            ::.:||.|              |.....| .||.:    |.:.:....|...:|:.:..::::..
Human   392 SQRVQNKL--------------GVVFEKE-KDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQD 441

  Fly   534 RPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIG 598
            .|.|..|.:||:|:.      |:....::..|..   :....|.|.:|     .|..|.|||..|
Human   442 EPDMISVFIGTWNMG------SVPPPKNVTSWFT---SKGLGKTLDEV-----TVTIPHDIYVFG 492

  Fly   599 FEEIVDLNASNIMAASTDNAKLWAEELQKTISR--DNDYVLLTYQQLVGVCLYIYIRPEHAPHIR 661
            .:|            ::...:.|.:.|:..:..  |.||..:..|.|..:.:.:.::|||...|.
Human   493 TQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRIS 545

  Fly   662 DVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMG 726
            .|:...||||:....|||||..:.|:.:|||..||..|..:|..:.|.||.:|.:|.|.|:  :|
Human   546 HVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLS--LG 608

  Fly   727 -RTLKSHD------WVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFL 784
             |.|.:.|      .:||.||.|||:||:..|:...:...:...:|..|||..|:|...||..|.
Human   609 DRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFS 673

  Fly   785 EGEITFDPTYKYDLFSDDYDTSEKQR-------APAWTDRVLWRR-----------RKALAEGDF 831
            |.||:|.|||:|:..|.|.....||:       .|:|.||:||:.           .::|.:...
Human   674 EEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGQSLPDRVM 738

  Fly   832 AASAWNPGKLI-HYGR----------------------SELKQSDHRPVI--------------- 858
            ....|:|..|. :.||                      .::..|||.||.
Human   739 GDLGWSPSGLCPNLGRWEPRVGIFPLSPHSYPLSPGCTDDIVTSDHSPVFGTFEVGVTSQFISKK 803

  Fly   859 --------AIIDAEIME-IDQQRRRAVF-------------EQVIRDLGPPDSTIVVHVLESSAT 901
                    |.|:.|.:| |.:...|..|             :....|....|:...:.|..||..
Human   804 GLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQ 868

  Fly   902 GDEDGPTIYDENVMS---ALITELS-----KMGE--VTLVRYVEDT--MWVTF--RDGESALNAS 952
            .....|.:.|...:.   .|:|..|     ..||  |.|...:..|  .::||  ..||...|..
Human   869 LPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIR 933

  Fly   953 SKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQ-------LLQAITP--E 1008
            ....::|....|....:..:|.. :|.: |....:..|..:...:..:       ..:|..|  .
Human   934 GSMKVRVPTERLGTRERLYEWIS-IDKD-EAGAKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSR 996

  Fly  1009 LPQRPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMPPQPQSQPLIPSPLQPQVA 1073
            |.:.|::||  |..|||.|  |:.:||..|      :.|: .||...|:|:.           ||
Human   997 LFEEPEKPP--PTGRPPAP--PRAAPREEP------LTPR-LKPEGAPEPEG-----------VA 1039

  Fly  1074 PPRPPAMDTTPSSKSQSPTELVSASSSTSSSGKTSPTAPA--VLSG------PPTPPRQMQ---- 1126
            .|.|                            |.|...||  ||.|      ||.||...:
Human  1040 APPP----------------------------KNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVP 1076

  Fly  1127 --SKQATPVSTPTRQVGSPKDPIPSDTAYETASNIYEEIQEDVPAPRHPPPAGPPPVIGAPMG-- 1187
              :|....::.|..|:|..:.|...:     .|:..||....:|.|..|||..|...|..|..
Human  1077 SATKNKVAITVPAPQLGHHRHPRVGE-----GSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLD 1136

  Fly  1188 --PPPPLPNR-----RGPPPIPNRSGNAPPLPTRPA 1216
              |.|.:..|     ||||  |.::...||||..|:
Human  1137 PLPGPVVRGRGGAEARGPP--PPKAHPRPPLPPGPS 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	106/397 (27%)
		DUF1866	862..1008	CDD:286093	33/182 (18%)
INPPL1	XP_024304269.1	SH2_SHIP	17..119	CDD:198206
		EEP	446..793	CDD:321002	104/374 (28%)
		Atrophin-1	<965..1280	CDD:331285	65/263 (25%)
		SAM_Ship2	1260..1322	CDD:188890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740