DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and INPP5D

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001017915.1	Gene:	INPP5D / 3635	HGNCID:	6079	Length:	1189	Species:	Homo sapiens

Alignment Length:	900	Identity:	208/900 - (23%)
Similarity:	321/900 - (35%)	Gaps:	280/900 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 VLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRS 555
            |:|| .|...::..:..:...|........:|:::..:::|...|.|..:.:||:|:......:.
Human   358 VILV-ETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKK 421

  Fly   556 IVFKDSLADWLLDCHALARSKALVDVNNPSENVDH-PVDIYAIGFEEIVDLNASNIMAASTDNAK 619
            |      ..|.|       ||.  ......::.|: |.|||.||.:|            ...:.|
Human   422 I------TSWFL-------SKG--QGKTRDDSADYIPHDIYVIGTQE------------DPLSEK 459

  Fly   620 LWAEELQKTISRDNDYVLLT--YQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGAC 682
            .|.|.|:.::.........|  ...|..:.:.:..:|||...|..:..|.||||:....|||||.
Human   460 EWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAV 524

  Fly   683 AIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAF------PMGRTLK-SHDWVFWCGD 740
            .:.|:.:|||:.||.:|..:|..:...||.:|..|.|.||.      |...|.: :|  :||.||
Human   525 GVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTH--LFWFGD 587

  Fly   741 FNYRIDM---EKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDD 802
            .|||:|:   |.:.:.:.::....:.:|..|||..|:....||..|.|.||||.|||:::..:.|
Human   588 LNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRD 652

  Fly   803 YDTSEKQRA-------PAWTDRVLWRRRKALAEGDFAASAWNPGKLIH-----YG-RSELKQSDH 854
            .....||:|       |:|.|||||:..                .|:|     || .|::..|||
Human   653 KYAYTKQKATGMKYNLPSWCDRVLWKSY----------------PLVHVVCQSYGSTSDIMTSDH 701

  Fly   855 RPVIAIIDAEIME----------IDQQ------RRRAV--------------------------- 876
            .||.|..:|.:..          :|.|      |..|.
Human   702 SPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEG 766

  Fly   877 -------------FEQVIRDLGP----PDSTIVVHVLESSATGDEDGPTIYDENVMS-------- 916
                         |.:.:..|.|    |:..:..|:|.|..:.|.|  ..|.|..::
Human   767 ENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSD--ESYGEGCIALRLEATET 829

  Fly   917 --ALITELSKMGEVTLVRYVEDTMWVTFRDGESALNASSKKS------------IQVCGLDLILE 967
              .:.|.|:..||:|           ....||..|..|..|:            .:..|...:..
Human   830 QLPIYTPLTHHGELT-----------GHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKS 883

  Fly   968 LKS----KDWQHLVDSEIELCTTNTIPLCANP------------VEHAQLLQAITPEL------- 1009
            |.|    |.|:  |.|....|:.::|....||            ..|.:  |.::|:.
Human   884 LTSHDPMKQWE--VTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVK--QTLSPDQQPTAWSY 944

  Fly  1010 ----------PQRPKQPPTRPPARPPM---------------PMSPKNSPRHL------------ 1037
                      |.|.:.||| ||.:||:               |.:.::.|..|
Human   945 DQPPKDSPLGPCRGESPPT-PPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQED 1008

  Fly  1038 -----------PHVGVISIVPKPA------KPPMP---PQPQSQPLIPSPLQPQVAPPRPPAMDT 1082
                       |..|.:|..||||      .|.||   |.|..:|.|   |.|.:...:....|.
Human  1009 LPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGI---LSPSIVLTKAQEADR 1070

  Fly  1083 TPSSKSQSPT-ELVSASSSTSSSGKTS--------PTAPAVLSGP-----PTPPRQMQSKQATPV 1133
            ......|.|. .|.|.:.|:|:.|:.:        |..|.....|     |..|.:.:..|.||
Human  1071 GEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTP- 1134

  Fly  1134 STPTRQVGSPKDPIP--SDTAYETASNIYEEIQEDVPAP---RHPPPAGPPPVIG 1183
            .|||     |:.|:|  |........:...:.:::...|   :|.|..|||..:|
Human  1135 PTPT-----PRPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLG 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	101/350 (29%)
		DUF1866	862..1008	CDD:286093	39/243 (16%)
INPP5D	NP_001017915.1	SH2_SHIP	1..102	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..132
		SH3-binding 1	124..129
		INPP5c_SHIP1-INPP5D	404..710	CDD:197334	101/350 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..906		8/37 (22%)
		PHA03307	899..>1127	CDD:223039	48/233 (21%)
		NPXY motif 1	912..915		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	922..1189		60/274 (22%)
		SH3-binding 2	969..974		1/4 (25%)
		Interaction with DAB2. /evidence=ECO:0000250	1016..1030		3/13 (23%)
		NPXY motif 2	1019..1022		1/2 (50%)
		SH3-binding 3	1040..1051		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146119
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740