DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and INPP5B

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001352749.1	Gene:	INPP5B / 3633	HGNCID:	6077	Length:	913	Species:	Homo sapiens

Alignment Length:	672	Identity:	182/672 - (27%)
Similarity:	284/672 - (42%)	Gaps:	129/672 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 ISRFE--EIFRQMWINNG-NEVSKIYAGTGAIQGGSKLMDGARSAARTI---------------- 476
            :||:.  |:..:|....| |.....:.|...|.||....||.|...:.:
Human   144 LSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQ 208

  Fly   477 --QNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMAR 539
              ||    .||.|..| ::..||::  ::|:|.||.........|.|...|.::..:|...:..|
Human   209 PRQN----KSKSEITD-MVRSSTIT--VSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFR 266

  Fly   540 VAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVD 604
            ...|||||||...      |:.|..||                  |..:..| |:|.:||:|: |
Human   267 FFAGTYNVNGQSP------KECLRLWL------------------SNGIQAP-DVYCVGFQEL-D 305

  Fly   605 LNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVK 669
            |:........|...:.|.:.:.:.:..|..|..:...:|||:.|.:|::.|||.:|.:|..:.|.
Human   306 LSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG 370

  Fly   670 TGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAF--------PMG 726
            ||:.|..||||..||||..|.||:|.|.:|.||...:...||.||.:|..::.|        |:
Human   371 TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL- 434

  Fly   727 RTLKSHDWVFWCGDFNYRI-DMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITF 790
             |:.:||.:.|.||.|||| :::.:::|:.:...|...:..:|||:.:..|..||..|.|||:||
Human   435 -TISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTF 498

  Fly   791 DPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHR 855
            .||||||..|||:|||||.|||||.||:||:.:             |..:|.:.....||.|||:
Human   499 QPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-------------NITQLSYQSHMALKTSDHK 550

  Fly   856 PVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHV------------------LESSATG 902
            ||.::.|..:..::.:..|...|:::|.|...::..:..|                  :||....
Human   551 PVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIH 615

  Fly   903 DEDGPTIY-------DENVMSALITELSKMG--------EVTLVRYVEDTMWVTFRDGESALNAS 952
            :...|..:       :|:.....:......|        |:.|..:|..........||..:
Human   616 NGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKI--- 677

  Fly   953 SKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLC-ANPVEHAQLLQAITPELPQRPKQP 1016
              :.|.|..||     :.||:...|..       |.:|.| .:|:.....::....:||......
Human   678 --EDILVLHLD-----RGKDYFLSVSG-------NYLPSCFGSPIHTLCYMREPILDLPLETISE 728

  Fly  1017 PTRPPARPPMPMSPKNSPRHLP 1038
            .|..|.......|..:||..:|
Human   729 LTLMPVWTGDDGSQLDSPMEIP 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	118/333 (35%)
		DUF1866	862..1008	CDD:286093	27/179 (15%)
INPP5B	NP_001352749.1	INPP5B_PH	6..150	CDD:318889	2/5 (40%)
		INPP5c_INPP5B	265..558	CDD:197327	118/333 (35%)
		RhoGAP_OCRL1	692..912	CDD:239845	13/66 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810