DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and inppl1a

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001034893.1	Gene:	inppl1a / 325179	ZFINID:	ZDB-GENE-030131-3904	Length:	1266	Species:	Danio rerio

Alignment Length:	1018	Identity:	223/1018 - (21%)
Similarity:	360/1018 - (35%)	Gaps:	314/1018 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 NCLDCLDRT---NCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNE-----VSK 451
            |.|..|::|   :|.:.:..:|.:...||.|.....||:.|....:.:|.....|::     |:|
Zfish   187 NSLPHLNKTLLSSCKRLHGEVDKVLCGLEILSKVFDQQSASMVSRMIQQSMSQGGDQELEHLVTK 251

  Fly   452 IYAGTGAIQGGSK-----LMD-----GARSAARTIQNNLLDNSKQEA-IDVLL-----VGSTLSS 500
            :......:....|     |.|     .|.|...:|:|.::.....|. :||.|     :|.:...
Zfish   252 LAILKDLLSSIEKKALKALQDMSSSTPAISPLLSIRNKVIPVQTFEVKLDVYLADLTKIGKSQKY 316

  Fly   501 ELA--------------------------DRARILLPSNMLHAPTTVLRE--------------- 524
            .|:                          |:.|.|:.|..:.....::.|
Zfish   317 SLSVDVEGGKLVVMKKMKDAQEDWNTFTHDKIRQLIKSQRVQNKLGIVFEKEKDKSQRKDFIFAS 381

  Fly   525 ------LCK-------RYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSK 576
                  .|:       :::....|.|..:.:||:|:.      |:.....|..|:|   :....|
Zfish   382 AKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMG------SVPAPKPLGSWIL---SRGLGK 437

  Fly   577 ALVDVNNPSENVDHPVDIYAIGFEE--IVDLNASNIMAASTDNAKLWAEELQKTISR--DNDYVL 637
            .|.::     .|..|.|||..|.:|  :.|              |.|.|.|:.::..  |.:|..
Zfish   438 TLDEM-----AVTIPHDIYVFGTQENSVCD--------------KEWVETLRCSLKEYTDMEYKP 483

  Fly   638 LTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAA 702
            :..|.|..:.:.:.::.||...|..|.:..||||:....|||||..:.|:.:|||..||..|..:
Zfish   484 IAVQTLWNIKIVVLVKAEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTS 548

  Fly   703 GQSQVAERNADYAEITRKLAFPMG-RTLKSHD------WVFWCGDFNYRIDMEKDELKECVRNGD 760
            |..::..||.:|.:|.|:|:  :| :.|.|.|      .:||.||.|||:||:..|:...:...:
Zfish   549 GNEKIHRRNQNYLDILRQLS--LGDKQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILNYINRKE 611

  Fly   761 LSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRA-------PAWTDRV 818
            ...:|:.|||..|:|...:|..|.|.||::.|||:|:..|.|....:||:|       |:|.||:
Zfish   612 FDPLLKVDQLNLEREKNKIFLRFAEEEISYPPTYRYERGSRDTYVWQKQKATGMRTNVPSWCDRI 676

  Fly   819 LWRRRKALAEGDFAASAWNPGKLIHYG-RSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIR 882
            ||   |:..|.....::        || ..::..|||.||....:.           .|..|.:.
Zfish   677 LW---KSYPETHIVCNS--------YGCTDDIVTSDHSPVFGTFEV-----------GVTSQFVS 719

  Fly   883 DLGPPDSTIVVHV------------------LESSATGDEDGPTIYDENVMSALITELSKMGEVT 929
            ..|.|.|:...::                  :|..:|..|:....|:.:..|:......::|
Zfish   720 KKGLPKSSEQAYIEFENIEAIVKTASRTKFFIEFYSTCLEEFKKSYENDTQSSDNVNFLRVG--- 781

  Fly   930 LVRYVEDTMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCAN 994
                     |            |||   |:..|..||    .|.::|.|..:.|    |:.....
Zfish   782 ---------W------------SSK---QLTTLKPIL----SDIEYLQDQHLLL----TVKSLDG 814

  Fly   995 PVEHAQLLQAITPELPQRPKQPPT------------RPPARPPMPMSPKNSPRHLPHVGVISI-- 1045
            ...:.:.:.|:...:....:|..|            |...|..:|.....:...|  ...||:
Zfish   815 YESYGECVLALKSMIGSTAQQFHTYLSHRGEETGNIRGSMRVRVPSERMGTRERL--YEWISVDK 877

  Fly  1046 --VPKPAKPPMPPQPQSQPLIPSPLQPQVAPPRPPAMDTTPSSKSQSPTELVSAS-----SSTS- 1102
              :..|....:||:.....:.|:               ::.||:.....||...|     ||||
Zfish   878 DDMGGPKGRTLPPRTSHDYVKPT---------------SSSSSRKHGSAELSRVSEEGEKSSTSR 927

  Fly  1103 ----------SSGKTSP-----------------------------TAPAVLSGPPTPPRQMQSK 1128
                      :.||..|                             .|..:|.|...||  :.:|
Zfish   928 HPHTKEENTHNRGKQDPFESDATTCKNSFNNPAYYILEGVPNQSAALASDILPGSALPP--LANK 990

  Fly  1129 QATPVSTPTRQVGSPKDPIPSDT--AYETASNIYEEIQED---------VPAPRHPPPAGPPPVI 1182
            ...|   |...||..|.|..|..  .::|:......|.|:         ||   |......||
Zfish   991 TTAP---PAGSVGKSKPPSGSSAQGRWQTSGRSVRPISEEGSSEDDGNIVP---HTGSLNRPP-- 1047

  Fly  1183 GAPMGPPPPLP--------NRRGPPPIPN--RSGNAPPLPTRP 1215
              |..||||||        |..|.|.:.:  ..|..|| |::|
Zfish  1048 --PDFPPPPLPKAALEMSENSFGKPRVFSDLADGKIPP-PSKP 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	101/343 (29%)
		DUF1866	862..1008	CDD:286093	25/163 (15%)
inppl1a	NP_001034893.1	SH2_SHIP	15..113	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..159
		INPP5c_SHIP2-INPPL1	408..711	CDD:197335	101/343 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..951		16/86 (19%)
		NPXY motif	958..961		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	986..1132		32/115 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1174
		SAM_Ship2	1204..1263	CDD:188890
		SAM	1207..1263	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840