DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Ocrl

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_796189.2	Gene:	Ocrl / 320634	MGIID:	109589	Length:	900	Species:	Mus musculus

Alignment Length:	791	Identity:	200/791 - (25%)
Similarity:	320/791 - (40%)	Gaps:	180/791 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 QPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYG-YQTVVNLLGSSLVGSKEGEAMLSNEFQR 331
            :|.:.:|:..:.:..|.|......:..:..:.:|.| |:.::.|
Mouse     2 EPRLPIGAQPLAMVAGLEMKGPLREPCVLTLARRNGQYELIIQL--------------------- 45

  Fly   332 HHGMSAH-KDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHASN-GQVLREQFGVVRT 394
             ||...| :|:  :..:.|..|       :.:.:|.::       :..||| |..:|.|....|.
Mouse    46 -HGKEQHVQDI--IPINSHFRC-------VQEAEETLL-------IDIASNSGCKIRVQGDWTRE 93

  Fly   395 NCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSK-IYAGTGA 458
            ...:..|...|:: :|.        |.|:....|..:...|:.....|....:.:.| .|:|...
Mouse    94 RHFEIPDEERCLK-FLS--------EVLEAQEAQSQLLVPEQKDSSSWYQKLDTMDKPAYSGLLG 149

  Fly   459 IQGGSKLMD--------GARSAAR-------TIQNNLLDNSKQEAIDVLLVGSTLSSELADRARI 508
            .:.....:|        ..||.:.       :....:|...|:             :...::.::
Mouse   150 FEDNFSSLDLDKKMNTQNPRSGSHREPPPPPSSSTRMLSREKE-------------ASNKEQPKV 201

  Fly   509 LLPSNMLHAPTT--------VLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADW 565
            ......|..|.|        :...|.||..|||..:..|..|||:||||...      ..||..|
Mouse   202 TNTMRKLFVPNTQTGQREGLIKHILTKREKEYVNIQSFRFFVGTWNVNGQSP------DSSLEPW 260

  Fly   566 LLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTIS 630
             |||          |.|        |.|||.|||:|: ||:........:...:.|:..:::.:.
Mouse   261 -LDC----------DPN--------PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSLAVERGLP 305

  Fly   631 RDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCF 695
            ....|..:...:|||:.|.|:.|.:...:|||||.:...||:.|..||||..|:|||.|.|:.|.
Mouse   306 SKAKYRKVQLVRLVGMMLLIFARKDQCQYIRDVATETTGTGIMGKMGNKGGVAVRFVFHNTTFCI 370

  Fly   696 VCAHFAAGQSQVAERNADYAEITRKLAF-------PMGRTLKSHDWVFWCGDFNYRIDM-EKDEL 752
            |.:|.||...:...||.||.:|..::.|       |....:| ||.|.|.||.|||:.| :..|:
Mouse   371 VNSHLAAHVEEFERRNQDYKDICARMTFSVPNQTVPQVNIMK-HDVVIWLGDLNYRLCMPDASEV 434

  Fly   753 KECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDR 817
            |..:...:|..:|:||||..::.....|.:|.||||.|.||||||..:|.:|:|.|.|.|||.||
Mouse   435 KSLINKNELHKLLKFDQLNIQRTQKKAFADFNEGEINFVPTYKYDSKTDRWDSSGKCRVPAWCDR 499

  Fly   818 VLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIR 882
            :|||             ..|..:|.:....|||.|||:||.|:....:..:|::|.|.|||.::|
Mouse   500 ILWR-------------GINVNQLHYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVR 551

  Fly   883 DLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALIT----ELSKMGEV----TLVRYVEDTM- 938
            .:...::..:.. ||.|..      ..:.|||....:.    ::|..|:|    :.:..:.|:.
Mouse   552 IMDRMENDFLPS-LELSRR------EFFFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQY 609

  Fly   939 ---WVTFRDGESALNAS-----------SKKSIQV--CGLD-----LILEL-KSKDWQHLVDSEI 981
               |:.....|..|..:           ||.|:.:  .|.|     |:|.| :.||:...:..
Mouse   610 CKPWLRAEPFEGYLEPNETLDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTIGG-- 672

  Fly   982 ELCTTNTIPLC 992
                 |.:|.|
Mouse   673 -----NYLPSC 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	13/86 (15%)
		INPP5c_Synj	538..863	CDD:197323	120/332 (36%)
		DUF1866	862..1008	CDD:286093	33/162 (20%)
Ocrl	NP_796189.2	PH_OCRL1	11..115	CDD:270182	25/150 (17%)
		Clathrin box 1	73..77		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..201		4/53 (8%)
		5-phosphatase. /evidence=ECO:0000250	236..562		127/365 (35%)
		INPP5c_INPP5B	239..532	CDD:197327	120/332 (36%)
		ASH. /evidence=ECO:0000250	563..677		24/127 (19%)
		RhoGAP_OCRL1	667..895	CDD:239845	3/19 (16%)
		Clathrin box 2	701..705
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740