DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Ocrl

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001101726.2	Gene:	Ocrl / 317576	RGDID:	1594526	Length:	899	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	198/797 - (24%)
Similarity:	319/797 - (40%)	Gaps:	193/797 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 QPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYG-YQTVVNLLGSSLVGSKEGEAMLSNEFQR 331
            :|.:.:|:..:.:..|.|......:..:..:.:|.| |:.::.|
  Rat     2 EPRLPIGAQPLAMVAGLEMKGPLREPCVLTLARRNGQYELIIQL--------------------- 45

  Fly   332 HHGMSAH-KDVPHVVFDYHQECRGGNFSALAKLKER-IVACGANYGVFHASNGQVLREQFGVV-- 392
             ||...| :|:  :..:.|..|       :.:.:|. ::...:|.|......|...||:...:
  Rat    46 -HGKEQHVQDI--IPINSHFRC-------VQEAEETLLIDIASNSGCKIRVQGDWTRERHFEIPD 100

  Fly   393 RTNCLDCLDRTNCVQT----------------YLGLDTLGIQLEALKMGGKQQNISRFEEIFRQM 441
            ...||..|......|.                |..|||        |.......:..||:.|..|
  Rat   101 EERCLKFLSEVLAAQEAQSQLLVPEQKDSSNWYQKLDT--------KDKPAYSGLLGFEDNFSSM 157

  Fly   442 ----WINNGNEVSKIYAGTGAIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSEL 502
                .:|..|..:.|:                |.......:|.:...::||::
  Rat   158 NLDKKMNTQNPPTGIH----------------REPPPPPSSNRMLPREKEALN------------ 194

  Fly   503 ADRARILLPSNMLHAPTT--------VLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFK 559
            .::.::......|.||.:        :...|.||..|||..:..|..|||:||||...      .
  Rat   195 KEQPKVTNTMRKLFAPNSQSGQREGLIKHILAKREKEYVNIQSFRFFVGTWNVNGQSP------D 253

  Fly   560 DSLADWLLDCHALARSKALVDVNNPSENVD-HPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAE 623
            .||..||                    |.| :|.|||.|||:|: ||:........:...:.||.
  Rat   254 SSLEPWL--------------------NCDPNPPDIYCIGFQEL-DLSTEAFFYFESVKEQEWAM 297

  Fly   624 ELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVL 688
            .:::.:.....|..:...:|||:.|.::.:.:...:|||:|.:.|.||:.|..||||..|:|||.
  Rat   298 AVERGLPSKAKYKKVQLVRLVGMMLLVFAKKDQCQYIRDIATETVGTGIMGKMGNKGGVAMRFVF 362

  Fly   689 HGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPM-GRTL-----KSHDWVFWCGDFNYRIDM 747
            |.|:.|.|.:|.||...:...||.||.:|..:::|.: .:||     ..||.|.|.||.|||:.|
  Rat   363 HNTTFCIVNSHLAAHVEEFERRNQDYKDICARMSFSVPNQTLPQVNIMKHDVVIWLGDLNYRLCM 427

  Fly   748 -EKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRA 811
             :.:|:|..:...:|..:|:||||..::.....|.:|.||||.|.||||||..:|.:|:|.|.|.
  Rat   428 PDANEVKSLINKNELQKLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRV 492

  Fly   812 PAWTDRVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAV 876
            |||.||:|||             ..|..:|.:....|||.|||:||.|:....:..:|::|.|.|
  Rat   493 PAWCDRILWR-------------GINVNQLHYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKV 544

  Fly   877 FEQVIRDLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALIT----ELSKMGEV----TLVRY 933
            ||.::|.:...::..:..:       |........|||....:.    ::|..|:|    :.:..
  Rat   545 FEDIVRIMDRMENDFLPSL-------DLSRREFMFENVKFRQLQKEKFQISNNGQVPCHFSFIPK 602

  Fly   934 VEDTM----WVTFRDGESALNAS-----------SKKSIQV--CGLD-----LILEL-KSKDWQH 975
            :.||.    |:.....|..|..:           ||.|:.:  .|.|     |:|.| :.||:..
  Rat   603 LNDTQYCKPWLRAEPFEGYLEPNETIDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFL 667

  Fly   976 LVDSEIELCTTNTIPLC 992
            .:..       |.:|.|
  Rat   668 TISG-------NYLPSC 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	13/86 (15%)
		INPP5c_Synj	538..863	CDD:197323	117/332 (35%)
		DUF1866	862..1008	CDD:286093	32/162 (20%)
Ocrl	NP_001101726.2	PH_OCRL1	11..115	CDD:270182	21/134 (16%)
		Clathrin box 1	73..77		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..186		5/41 (12%)
		5-phosphatase. /evidence=ECO:0000250	235..561		124/365 (34%)
		INPP5c_INPP5B	238..531	CDD:197327	117/332 (35%)
		ASH. /evidence=ECO:0000250	562..676		23/127 (18%)
		RhoGAP_OCRL1	666..894	CDD:239845	3/19 (16%)
		Clathrin box 2	700..704
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840