Protein Alignment Synj and Inpp5f

DIOPT Version :10

• Sequence 1: NP_569729.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001101024.2
• Gene: Inpp5f / 309008
• RGDID: 1305777
• Length: 1130
• Species: Rattus norvegicus
• Alignment Length: 1240
• Identity: 265/1240 - (21%)
• Similarity: 441/1240 - (35%)
• Gaps: 365/1240 - (29%)

  Fly    62 GCLGALQLNAGESTVLFLVLVTGCVSMGKI-GDIEIFRITQTTFVSLQN---------------- 109
            |.:|.:||::  ....:|:|:.....:||: ||.|:.::|:...:||..
  Rat    50 GVIGKIQLHS--DLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQELELELCKKHHF 112

  Fly   110 -----------------------------AAPNEDKISE---------------VRKLLNSGTFY 130
                                         :|||:.|:.|               ::..::|.:||
  Rat   113 GINKPEKIVPSPDDSKFLLKTFTNIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFY 177

  Fly   131 FAHTNASASASGASSYRFDITLCAQR--------RQQTQETDNRFFWNRMMHIHLMRFGI-DCQS 186
            ::.|             :|:|...||        |...|:.|:|||||:.|...|...|. |...
  Rat   178 YSLT-------------YDLTNSVQRQSTGEKDGRPLWQKVDDRFFWNKYMIQDLSEIGTPDVDF 229

  Fly   187 WLLQAMCGSVEVRTVYIGAKQA------------------------RAAIISRLSCERAGTRFNV 227
            |::..:.|.|::..:.:..:.:                        ..|:|||.|..|||.|:..
  Rat   230 WIIPIIQGFVQIEELVVNYEPSDDDKSSPETPPQEATCVDDIHPRFLVALISRRSRHRAGMRYKR 294

  Fly   228 RGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFD 292
            ||.:..|.|||:|||||:|:|.....|::|||||||:||.|.|.:. :.:.:|.:..:.:...|.
  Rat   295 RGVDKNGNVANYVETEQLIHVHNHTLSFIQTRGSVPVFWSQVGYRY-NPRPRLDKSEKETVDCFC 358

  Fly   293 RHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNF 357
            .|.....:.|..|.:||     ||.....|.::.:.:.:...:..:..:.:|.||:|:.|||..|
  Rat   359 AHFEEQLKIYKKQVIVN-----LVDQAGREKIIGDAYLKQVLLFNNPRLTYVSFDFHEHCRGMKF 418

  Fly   358 SALAKLKERIVACGANYGVFHASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEAL 422
            ..:..|.:.|.....:..........|:.:|.|:.|.||:|||||||.||..:....:..||:.|
  Rat   419 ENVQTLTDAIHDIILDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKL 483

  Fly   423 KMGGKQQNIS-RFEEIFRQMWINNGNEVSKIYAGTGAIQG-----GSK-----LMDGARSAARTI 476
            .:...:|.:. :....::.||.|||:.:|:.||||.|::|     |.:     :.||..||.|..
  Rat   484 GVMPPEQPLPVKCNRTYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYY 548

  Fly   477 QNNLLDNSKQEAIDVLLVGSTLSSEL-----ADRARILLPSNMLHAPTTVLRELCKRYTEYVRPR 536
            .:...|..:|..|| |:.|..::.:|     .::....|......:...::.:|.:.|.:.:.|
  Rat   549 LSRFKDAYRQAVID-LMQGIPVTEDLYSIFTKEKEHEALQKETQRSHQELISQLLQSYMQLLLP- 611

  Fly   537 MARVAVGTYNVNGGKHFRSIVFKDSLADW-LLDCHALARSKALVDV------NNPSENV---DHP 591
                  |....:||              | |:||.......|..||      :|.:..|   |..
  Rat   612 ------GDEKFHGG--------------WALIDCDPSLTDAAHRDVDVLLLLSNSAYYVAYYDDE 656

  Fly   592 VD-IYAIGFEEIVDLNASNIMAAST--DNAKLWAEELQKTISRDNDY------------------ 635
            || :.......:.||....|....|  ...|.....|..|......|
  Rat   657 VDKVSQYQRRSLEDLEKIEIGPEPTLFGKPKFSCMRLHYTCKEAGGYFHTLRAVPRSPEEDGKDT 721

  Fly   636 ------VLLTYQQLVGVCLYIYI------RPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVL 688
                  :|...:|.:|  |::.|      |....|| .|:        :|..:.|:|:.|
  Rat   722 LQCIAEMLQITKQAMG--LHVPIIERKLERKSSKPH-EDI--------IGIRSQNQGSLA----- 770

  Fly   689 HGTSMCFVCAHFAAGQSQV--AERNADYAEITRKLAFPMGRTLKSHDWVFWCGDF---NYRIDME 748
            .|.|  |:.:.|::...:|  .:.|.:...: |||                 |:|   ..:::..
  Rat   771 QGKS--FLMSKFSSLNQKVKQTKSNVNIGNL-RKL-----------------GNFTKPEVKVNFL 815

  Fly   749 KDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPA 813
            |..||..:...|.|.        :..|...|.|..::||...|       .|.|.|:..
  Rat   816 KPNLKVNLWKSDSSL--------ETMENPGVMGNKVQGESDGD-------VSSDNDSYH------ 859

  Fly   814 WTDRVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDH-RPVIAIIDAEIMEIDQQRRRAVF 877
             :|.:|...|.            ..||.:.........:|: .|...|| |....:..:.:.|..
  Rat   860 -SDELLTNSRS------------EEGKQLANSLESAGPTDYLLPSCGII-ASAPRLGSRSQSASS 910

  Fly   878 EQVIRDLGPPDSTIVVH------VLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVED 936
            ..|  .:..|....|.|      .|||..........|:       .:|..:|..:|...|:|:
  Rat   911 TDV--SIHAPSEATVGHGHELGKGLESPLKKSPSADNIH-------TLTGFAKPMDVYCQRFVQ- 965

  Fly   937 TMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQL 1001
                   |.::.:||.|:..        .:...|::..|.                .|||.:.:.
  Rat   966 -------DAQNKMNALSEVR--------AVAQNSEEGNHK----------------TNPVSNEET 999

  Fly  1002 LQAITPELPQRPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMPPQPQSQPLIPS 1066
            ......::|.||.|.........|..:|                    .:|..|...|..|...|
  Rat  1000 QSESVEQMPSRPSQLNVSCSVTGPQLLS--------------------VEPAHPAVSQKTPGSGS 1044

  Fly  1067 PLQPQVAPPRPPAMDTTPSSKSQ----SPTELVSAS----SSTSSSGKT------------SPTA 1111
            .|....|     .:..||||:|.    ||...:.:|    ::.:.:|.|            ||..
  Rat  1045 SLLDLEA-----GLCVTPSSESSSRAVSPFAKIRSSMVQVANITQAGLTHGINLAVAKVQKSPAE 1104

  Fly  1112 PAVLS 1116
            |.|::
  Rat  1105 PEVVN 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_569729.1	COG5329	61..493	CDD:227637	137/535 (26%)
		INPP5c_Synj	538..863	CDD:197323	70/373 (19%)
		DUF1866	862..1008	CDD:286093	24/151 (16%)
Inpp5f	NP_001101024.2	COG5329	50..566	CDD:227637	138/537 (26%)
		hSac2	593..695	CDD:463592	24/122 (20%)