Protein Alignment Synj and INPP5J

DIOPT Version :9

• Sequence 1: NP_001246454.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001271214.1
• Gene: INPP5J / 27124
• HGNCID: 8956
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 161/608 - (26%)
• Similarity: 250/608 - (41%)
• Gaps: 123/608 - (20%)

  Fly   593 DIYAIGFEEIVD-LNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEH 656
            |:.|||.:|:.. ||.....|..||.   |:|.....:...| :||::..::.||.|.::.:..|
Human   457 DMIAIGLQEVNSMLNKRLKDALFTDQ---WSELFMDALGPFN-FVLVSSVRMQGVILLLFAKYYH 517

  Fly   657 APHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKL 721
            .|.:|||..||.:|||||..||||..::|....|..:||:..|..|...:..:|..::..|....
Human   518 LPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQ 582

  Fly   722 AF--PMGRTLKSHDWVFWCGDFNYRID-MEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEF 783
            .|  |..:.:..||.|||.||.|:||: .:...:|..:.:..|..:.|.|||...:....:...|
Human   583 QFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGF 647

  Fly   784 LEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLI----HY 844
            .||.:.|.||:|:|:.::.||||.|:|.||||||:||   |..|.|...:.:......:    |.
Human   648 QEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILW---KVKAPGGGPSPSGRKSHRLQVTQHS 709

  Fly   845 GRSELKQ--SDHRPVIAIIDAEIMEIDQQR--RRAVFEQVIRDLGPPDSTIVVHVLESSATGDED 905
            .||.::.  |||:||.|....:....|...  |..|.::.:|    |:..:|.:.:|
Human   710 YRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVR----PEQAVVRYRME-------- 762

  Fly   906 GPTIYDENVMSALITELSKMGEVTLVRYVED---TMWVTFR--DGESALNASSKKSIQVCGLDLI 965
              |::..:....:  .|.::|    .|:.:|   .:|....  ||.:.....|::|:.....|.|
Human   763 --TVFARSSWDWI--GLYRVG----FRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFI 819

  Fly   966 LELKSKDWQHLV-----------DSEIELCTTNTIPLCANPVEHAQLLQAITPELPQRPKQPPTR 1019
            |...|.:...|:           .||:...:|::....:...:.:.|      ||        ..
Human   820 LGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTL------EL--------LA 870

  Fly  1020 PPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPP---------MPPQPQSQPLIPSPLQPQVAPP 1075
            |.:|.|   ||..|.||......::..|..|..|         ..|.|||:.|      .:|||.
Human   871 PKSRSP---SPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRL------SRVAPD 926

  Fly  1076 RPPAMDTTPSSKSQSPTELVSASSSTSSSGKTSPTAPAVLSG----PPTPPRQMQSKQATPVST- 1135
            |                      ||..||..:|...|:.|.|    ||..||.:....|..:.|
Human   927 R----------------------SSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETV 969

  Fly  1136 ---------PTRQVGSPKDPIPS 1149
                     |.|:..:|....||
Human   970 DPGGGGSWGPDREALAPNSLSPS 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	94/279 (34%)
		DUF1866	862..1008	CDD:286093	26/163 (16%)
INPP5J	NP_001271214.1	INPP5c_INPP5J-like	423..730	CDD:197328	94/279 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740