DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and syj2

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_595311.1	Gene:	syj2 / 2541098	PomBaseID:	SPBC577.13	Length:	889	Species:	Schizosaccharomyces pombe

Alignment Length:	976	Identity:	267/976 - (27%)
Similarity:	416/976 - (42%)	Gaps:	234/976 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ESHAVALLTQQETDVIRKQYTKVCD---AYGCLGALQ---------LNAGESTV----------- 76
            :..:||.:|::...:|:|...|..|   .:.|:...:         |..||..:
pombe     8 KERSVAFITEKYAAIIQKPSVKDSDCIITFTCISLEEFEKIKEYELLFGGEKILGTLGLFNYVCE 72

  Fly    77 -----LFLVLVTGCVSMGKIGDIE-IFRITQTTFVSL--------------QNAAP--------- 112
                 :||.:......:.:||:.: |.::...:|:||              :|::|
pombe    73 DMKEGVFLCVARKAKLVLRIGNRDPISKLENVSFISLDQELWDEELFEPMPRNSSPSSTFSTSTS 137

  Fly   113 ---NEDK-----------------------ISEVRKLLNSGTFYFAHTNASASASGASSYRFDIT 151
               |.:|                       :|::..||..|:||.: ||.|
pombe   138 DLNNIEKDNLVNSEYSSKYSSTTRIYPYHSLSQLTDLLTDGSFYVS-TNIS-------------- 187

  Fly   152 LCAQRRQQTQETDNR--FFWNRMM-----------HIHLMRFGIDCQSWLLQAMCGSVEVRTVYI 203
             |..|.|..|....:  :.|||.:           || |.:|    .:.||....|.||  .::|
pombe   188 -CFSRFQSEQPYGPKDIYCWNRFLITELDNHFSEAHI-LEKF----PNLLLHCFRGYVE--RMFI 244

  Fly   204 GAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQ 268
            .:..  .:|||::|...:...:...|.:|..|.:.|||||.::.:...|.|:||.||:||.|||:
pombe   245 DSMS--MSIISKVSSYGSRQTYPPSGIDDSSYCSMFVETEFIVEIAQTVFSFVQVRGTVPCFWEE 307

  Fly   269 PGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRHH 333
            .........:...|..:.|.:.|:.|.|.:.:.||...|::||     .:|..||.| .|..:||
pombe   308 QFSSWYGPSISFLRSSQASQSLFNFHFSKLYKAYGDIYVIDLL-----QTKGFEASL-YEAYKHH 366

  Fly   334 GMSAHKDVPHVVFDYHQECRGGNFSA--------------LA-KLKERIVACGANYGVFHASNGQ 383
            .|..  ..|.||..:|       |:.              || .|||      ..|......|..
pombe   367 LMLL--PFPAVVKKFH-------FTPDPARPDIDPRLETDLADDLKE------MGYTQKSIENDM 416

  Fly   384 VLREQFGVVRTNCLDCLDRTNCVQ---TYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINN 445
            :...|.||.|.|.||||.|||.:|   :.|.|..:...|:.    |...||.   |..|.:|.||
pombe   417 LESFQKGVFRINDLDCLGRTNVIQYQISRLVLKDIFFNLQI----GVTFNIL---EYLRHLWSNN 474

  Fly   446 GNEVSKIYAGTGAIQGGSKLMDGARSAARTIQNNLLDNSK---------------QEAIDVLLVG 495
            |:.::|:..|.|:|  ||   ...|...::|..:|.|.||               |.|| :||:|
pombe   475 GDAIAKLITGVGSI--GS---SATRRGRKSIAGSLSDISKSFGRMYVGRYPDVESQNAI-LLLLG 533

  Fly   496 STLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKD 560
            .     ..:::.:|:..::......|||:   |.:||...|...:...|:|.||     .:...|
pombe   534 C-----FPNQSPVLISESVSSYIQGVLRQ---RRSEYRVERDFSIFSSTFNANG-----KVPSTD 585

  Fly   561 SLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEEL 625
            .....||                |........|:|.:..:||:.||.|:::::|....::|.|::
pombe   586 EFKRLLL----------------PFGERTSAYDLYVVAVQEIITLNMSHLVSSSNQKLRIWEEKI 634

  Fly   626 QKTI-SRD--NDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFV 687
            ...: |||  |.|:|::..|:.||.|.::||.:....:..|.....|||.||.:.||||.||...
pombe   635 LMILNSRDSNNKYMLISSIQMAGVFLGVFIRKDDHLVVSKVTKTTRKTGFGGFSANKGAVAIEMN 699

  Fly   688 LHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDEL 752
            :..:..|||.:|||...:.::|||.:|..|:..|.||.|..:..|..:.|.||||||||.:.:|:
pombe   700 VCDSDFCFVSSHFAPKVNNISERNMEYTSISDNLVFPSGMKIYDHTNILWMGDFNYRIDSDNEEV 764

  Fly   753 KECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDR 817
            ::.|...||..:..:|||..|.:.|.||...:|.::||.||||:|..::|||||:|||.|:||||
pombe   765 RKLVELDDLDKLASYDQLCTEMKKGTVFHGLVEPQLTFLPTYKFDNGTNDYDTSDKQRVPSWTDR 829

  Fly   818 VLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIR 882
            :       ||...|..:.        |...:::.||||||.|....:|......::..    :||
pombe   830 I-------LATKSFTRNC--------YKSCDIRCSDHRPVFATFSLKIFSTCMDKKAG----IIR 875

  Fly   883 D 883
            |
pombe   876 D 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	87/379 (23%)
		INPP5c_Synj	538..863	CDD:197323	110/327 (34%)
		DUF1866	862..1008	CDD:286093	4/22 (18%)
syj2	NP_595311.1	COG5329	1..552	CDD:227637	146/607 (24%)
		Syja_N	62..370	CDD:280532	79/338 (23%)
		COG5411	539..>889	CDD:227698	122/381 (32%)
		EEP	569..858	CDD:294334	110/324 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm47352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.770