DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and SACM1L

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001306000.1	Gene:	SACM1L / 22908	HGNCID:	17059	Length:	609	Species:	Homo sapiens

Alignment Length:	514	Identity:	155/514 - (30%)
Similarity:	239/514 - (46%)	Gaps:	103/514 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 YGCLGALQLNAGESTVLFLVLVTGCVSMG--------KIGDIEIFRITQT----TFVSLQNAAPN 113
            :|.||.:.|.||.    :|:::|..:.:|        |..|.::....:|    |.:.||:   |
Human    58 FGILGTIHLVAGN----YLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQD---N 115

  Fly   114 EDKISEVRKLLNSGTFYFAHTNASASASGASSYRFDITLCAQRRQQT----------QETDNRFF 168
            :..::.:..:||...|||:.|             :|:|...||...|          :..|.||.
Human   116 KTFLAMLNHVLNVDGFYFSTT-------------YDLTHTLQRLSNTSPEFQEMSLLERADQRFV 167

  Fly   169 WNRMMHIHLMRFGIDCQ----SWLLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRG 229
            ||.    ||:| .:..|    .:.|..:.|.:.:.:..|..|.....:|||.||.|||.|:.|||
Human   168 WNG----HLLR-ELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRG 227

  Fly   230 TNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQ---------PGV-QVGSHKVKLSRGF 284
            .:.||:.||||||||:::.:|...|:||||||:|:||.|         |.: :|.:|
Human   228 IDSEGHAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPLPQISKVANH-------- 284

  Fly   285 ETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRHHGMSAHKDVPHVVFDYH 349
               ...|.||.......||.|.::|     |:..|..|..|...|...........:.::.||:|
Human   285 ---MDGFQRHFDSQVIIYGKQVIIN-----LINQKGSEKPLEQTFATMVSSLGSGMMRYIAFDFH 341

  Fly   350 QECRGGNFSALAKLKERIVACGANYGVFHA-SNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLD 413
            :||:...:..|:.|.:::.........|.. |.|||:..|.||.|:||:|||||||.:|:.|...
Human   342 KECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARR 406

  Fly   414 TLGIQLE---ALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYAGTGAI-----QGGSK-----L 465
            :|..||:   .|.:|.|.:....||:|::..|.:|.|..:|.||||||:     :.|.:     :
Human   407 SLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLI 471

  Fly   466 MDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRE 524
            |||..|..|..:||..|..:|::|| |.:|:....||..           |:|.:|.|:
Human   472 MDGWNSMIRYYKNNFSDGFRQDSID-LFLGNYSVDELES-----------HSPLSVPRD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	93/327 (28%)
		INPP5c_Synj	538..863	CDD:197323
		DUF1866	862..1008	CDD:286093
SACM1L	NP_001306000.1	COG5329	57..513	CDD:227637	152/507 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920