DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and INPP5F

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_055752.1	Gene:	INPP5F / 22876	HGNCID:	17054	Length:	1132	Species:	Homo sapiens

Alignment Length:	1272	Identity:	267/1272 - (20%)
Similarity:	460/1272 - (36%)	Gaps:	377/1272 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GCLGALQLNAGESTVLFLVLVTGCVSMGKI-GDIEIFRITQTTFVSLQN---------------- 109
            |.:|.:||::  ....:|:|:.....:||: ||.|:.::|:...:||..
Human    50 GVIGKIQLHS--DLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHF 112

  Fly   110 -----------------------------AAPNEDKISE---------------VRKLLNSGTFY 130
                                         :|||:.|:.|               ::..::|.:||
Human   113 GINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFY 177

  Fly   131 FAHTNASASASGASSYRFDITLCAQR--------RQQTQETDNRFFWNRMMHIHLMRFGI-DCQS 186
            ::.|             :|:|...||        |...|:.|:|||||:.|...|...|. |...
Human   178 YSLT-------------YDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDF 229

  Fly   187 WLLQAMCGSVEVRTVYIGAKQAR-------------------------AAIISRLSCERAGTRFN 226
            |::..:.|.|::..:.:...::.                         .|:|||.|..|||.|:.
Human   230 WIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYK 294

  Fly   227 VRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQPGVQVGSHKVKLSRGFETSAAAF 291
            .||.:..|.|||:|||||:|:|.....|:||||||||:||.|.|.:. :.:.:|.|..:.:.|.|
Human   295 RRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRY-NPRPRLDRSEKETVAYF 358

  Fly   292 DRHMSMMRQRYGYQTVVNLLGSSLVGSKE--GEAMLSNE--FQRHHGMSAHKDVPHVVFDYHQEC 352
            ..|.......|..|.::||:..:  |.::  |:|.|...  |...|       :.:|.||:|:.|
Human   359 CAHFEEQLNIYKKQVIINLVDQA--GREKIIGDAYLKQVLLFNNSH-------LTYVSFDFHEHC 414

  Fly   353 RGGNFSALAKLKERIVACGANYGVFHASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGI 417
            ||..|..:..|.:.|.....:..........|:.:|.|:.|.||:|||||||.||..:....:..
Human   415 RGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQ 479

  Fly   418 QLEALKMGGKQQNIS-RFEEIFRQMWINNGNEVSKIYAGTGAIQG-----GSK-----LMDGARS 471
            ||:.|.:...:|.:. :...|::.||.|||:.:|:.||||.|::|     |.:     :.||..|
Human   480 QLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNS 544

  Fly   472 AARTIQNNLLDNSKQEAIDVLLVGSTLSSEL-----ADRARILLPSNMLHAPTTVLRELCKRYTE 531
            |.|...|...|..:|..|| |:.|..::.:|     .::....|......:...::.:|.:.|.:
Human   545 ANRYYLNRFKDAYRQAVID-LMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMK 608

  Fly   532 YVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADW-LLDCHALARSKALVDVNNPSENVDHPVDIY 595
            .:.|       .....:||              | |:||     ..:|:|..:      ..||:.
Human   609 LLLP-------DDEKFHGG--------------WALIDC-----DPSLIDATH------RDVDVL 641

  Fly   596 AIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGV-------------- 646
            .:       |:.|....|..|      :|:.|.    |.|..|:.:.|..:
Human   642 LL-------LSNSAYYVAYYD------DEVDKV----NQYQRLSLENLEKIEIGPEPTLFGKPKF 689

  Fly   647 -CLYIYIRPEHAP---H-IRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQ 706
             |:.::.|.:.|.   | :|.|..:..:.|                 ..|..|.      |...|
Human   690 SCMRLHYRYKEASGYFHTLRAVMRNPEEDG-----------------KDTLQCI------AEMLQ 731

  Fly   707 VAER--NADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQ 769
            :.::  .:|...|.:||.   .::.|.|:.:...          :.:.:..:..|....:.:|..
Human   732 ITKQAMGSDLPIIEKKLE---RKSSKPHEDIIGI----------RSQNQGSLAQGKNFLMSKFSS 783

  Fly   770 LRK--EQEAGNV-------FGEFLEGEITFD---PTYKYDLFSDDYDTSEKQRAPAWTDRVLWRR 822
            |.:  :|...||       .|.|.:.|:..:   |..|.:|:..| .:.|........|:|
Human   784 LNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSD-SSLETMENTGVMDKV---- 843

  Fly   823 RKALAEGDFAA--SAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLG 885
             :|.::||.::  .:::..:.:...:|                     |:.|:.|   ..:..:|
Human   844 -QAESDGDMSSDNDSYHSDEFLTNSKS---------------------DEDRQLA---NSLESVG 883

  Fly   886 PPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESALN 950
            |.|     :||.|                 ..:|....::|..:          .:....:|:::
Human   884 PID-----YVLPS-----------------CGIIASAPRLGSRS----------QSLSSTDSSVH 916

  Fly   951 ASSKKSI-QVCGLDLILELKSKDWQHLVDSEIELCTTNTIPL---CANPVEHAQLLQAITPELPQ 1011
            |.|:.:: ...||....|...|......|  :.:.|....|:   |...|:.||
Human   917 APSEITVAHGSGLGKGQESPLKKSPSAGD--VHILTGFAKPMDIYCHRFVQDAQ----------- 968

  Fly  1012 RPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMPPQPQSQPLIPSPLQPQVAPPR 1076
                                |...||.....:|......:..|..|..::....|..|   .|.|
Human   969 --------------------NKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQ---TPSR 1010

  Fly  1077 PPAMD-----TTPSSKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTP 1136
            |..:|     |.|...|..|...| ||..|.:|..:.......|...|:|.....|:..:|.:
Human  1011 PSQLDVSLSATGPQFLSVEPAHSV-ASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFA-- 1072

  Fly  1137 TRQVGSPKDPIPSDTAYETASNI---YEEIQEDVPAP 1170
              ::.|....:.|.|.......|   ..::|:..|.|
Human  1073 --KIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEP 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	96/389 (25%)
		INPP5c_Synj	538..863	CDD:197323	57/360 (16%)
		DUF1866	862..1008	CDD:286093	25/149 (17%)
INPP5F	NP_055752.1	Syja_N	50..415	CDD:280532	96/389 (25%)
		hSac2	595..697	CDD:289241	24/150 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..875		5/49 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	923..942		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1017		10/45 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850