DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Synj2

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001106824.1	Gene:	Synj2 / 20975	MGIID:	1201671	Length:	1479	Species:	Mus musculus

Alignment Length:	1381	Identity:	555/1381 - (40%)
Similarity:	759/1381 - (54%)	Gaps:	221/1381 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65
            ||:||.:|:|.:.....|.|||||.|.:.|.:|||:.|||.|..:|.:||:..|:|:.|||||||
Mouse     1 MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYSKLTDAYGCLG 65

  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130
            .|:|.:|...:.||||||||:|:|:|.|.||::||.|....||..|..||::..::|:|:||.||
Mouse    66 ELRLQSGGVPLSFLVLVTGCMSVGRIPDAEIYKITATELYPLQEEAKEEDRLPTLKKILSSGVFY 130

  Fly   131 FAHTNASASASGASSYRFDITLCAQRR-QQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCG 194
            ||..|..|.        ||:|:.||:: ....|....||||:::|:.|.:..::|.:|||:.:||
Mouse   131 FAWPNDGAC--------FDLTIRAQKQGDDGSEWGTSFFWNQLLHVPLRQHQVNCHNWLLKVICG 187

  Fly   195 SVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTR 259
            .|.:||||...|||:|.:|||:||||||.||..||.||:|:|:|||||||.||:|..|:|:||.|
Mouse   188 VVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQTIYMDDGVSSFVQIR 252

  Fly   260 GSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAM 324
            |||||||||||:|||||.::|.||.|.:|.||:|||.:::::||.|.|||||     ||:.||.:
Mouse   253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGKQVVVNLL-----GSRGGEEV 312

  Fly   325 LSNEFQRHHGMSAHK-DVPHVVFDYHQECRGGNFSALAK-LKERIVACGANYGVFHASNGQVLRE 387
            |:..|::....|.|. |.|.:.||:||..:|.....|.. |:.::.....::|||........|.
Mouse   313 LNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLQLHWEDFGVFAKGENVSPRF 377

  Fly   388 QFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKI 452
            |.|.:|.||||||||||.||.::.|:.|.:|||:|.:..| ..|.||.|.|:.||..||:.:||:
Mouse   378 QKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSK-PIIDRFVESFKAMWSLNGHSLSKV 441

  Fly   453 YAGTGAIQGGS---KLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNM 514
            :.|:.|::|.:   ||.|||||.:||||:|..|..|||||.:||||...:.|..|:.|:||.:..
Mouse   442 FTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTA 506

  Fly   515 LHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRS-IVFKDSLADWLLDCHALARSKAL 578
            |.|...:|:.:.:|.:|:...:..::||||:||||||.||| ::....|.|||||...|:   ..
Mouse   507 LLATPRILKAMTERQSEFTNFKRIQIAVGTWNVNGGKQFRSNLLGTAELTDWLLDAPQLS---GA 568

  Fly   579 VDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQL 643
            ||    |::...|.|::||||||:|:|:|.||:.|||.|.|:|.|:|||.|||.:.|:|||..||
Mouse   569 VD----SQDDGSPADVFAIGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQL 629

  Fly   644 VGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVA 708
            |||||||::||.|.|.|||||||.||||:||..|||||..|||.||.||.||||:|..||||||.
Mouse   630 VGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQLHSTSFCFVCSHLTAGQSQVK 694

  Fly   709 ERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKE 773
            |||.||.|||.||:||.||.:.|||:||||||||||||:..:|:...|:..|...::|||||:.:
Mouse   695 ERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQ 759

  Fly   774 QEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRK----------ALAE 828
            :.:|.:|.:|.||.:.|.||||||:.|..||||:|.|.|||||||||.|:|          .|.:
Mouse   760 KSSGKIFKDFHEGAVNFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLD 824

  Fly   829 GDFAAS-----AWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPD 888
            .|....     .|:||.|.:|||:||:.||||||:||::.|:.|:|...|..||::|....||.|
Mouse   825 SDLDGDPQIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLD 889

  Fly   889 STIVVHVLESSATGDEDGPTI-----YDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESA 948
            :|:||::         ..||:     :.|::.:.|:..|...|.:.|||..:..|.|||.|..||
Mouse   890 ATVVVNL---------QSPTLEEKNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSA 945

  Fly   949 LNASSKKSIQVCGLDLILELKSKDW---------------------------------------- 973
            |:......::|.|..:.:..|:|||
Mouse   946 LSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELLRKRDSMAPVSPTANSCLLEENFDFSSLDYES 1010

  Fly   974 ---------QHLVD-------SEIELCTTNT------------IPLCANPVEHAQL-----LQAI 1005
                     .:|||       |:.||...|:            .|..|...:|...     |..:
Mouse  1011 EGDVLEEDEDYLVDGFGQPVVSDSELGGDNSSDTMSSLTPASKSPALAKKKQHPTYKDDAHLVTL 1075

  Fly  1006 TPEL-----------------PQRPKQPPTRPPARPPMP---MSPK-------NSPRHLPHVGVI 1043
            ..||                 |.||:  |..||.|||.|   |..|       :|..|    |..
Mouse  1076 KQELEVAGNFRHRSPSRSLSVPNRPR--PPHPPQRPPPPTGLMVKKSASDASISSGTH----GQY 1134

  Fly  1044 SIVPKPAKPPMPPQPQSQPLIP-SPLQPQVA------PPRPPAMDTTPSSKSQSPTE-LVSASSS 1100
            ||:            |:..|:| :|.||..|      |.....:.||.:.::::... |:.||..
Mouse  1135 SIL------------QTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEASGG 1187

  Fly  1101 TSSS----------GKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPTRQVGSPKDP----IPSDT 1151
            ...|          |.:.|.|..   |||..||:...:..|......|:.|.|..|    .|...
Mouse  1188 VPESAPGAIPLRNQGSSKPEATL---GPPALPRRPAPRVPTMKKPTLRRTGKPMLPEENFEPQPV 1249

  Fly  1152 AYETASNIYEEIQEDVPAPRHPPPAGPPP----------VIGAP-MGPPPP--LPNRRG----PP 1199
            .:..||   :|:..:.|.|....|..|.|          |.|.| .|.|.|  .|:..|    ||
Mouse  1250 HFTMAS---QEMNLETPPPITATPIPPVPKPRTLQPGKGVEGRPSSGKPEPDEAPSVTGTVESPP 1311

  Fly  1200 PIPNRSGN-APPLPTR 1214
            |....:.: ||.:|.|
Mouse  1312 PEAQEAPSLAPKVPPR 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	147/293 (50%)
		INPP5c_Synj	538..863	CDD:197323	188/340 (55%)
		DUF1866	862..1008	CDD:286093	47/223 (21%)
Synj2	NP_001106824.1	Syja_N	61..342	CDD:280532	147/293 (50%)
		EEP	530..861	CDD:294334	186/337 (55%)
		DUF1866	872..1008	CDD:286093	33/144 (23%)
		CEND1	1290..>1405	CDD:292305	13/38 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836221
Domainoid	1	1.000	54	1.000	Domainoid score	I11179
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm43870
orthoMCL	1	0.900	-	-		OOG6_101787
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1445
SonicParanoid	1	1.000	-	-		X1883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740