DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and sac-2

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001252206.1	Gene:	sac-2 / 173236	WormBaseID:	WBGene00012353	Length:	783	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	180/713 - (25%)
Similarity:	278/713 - (38%)	Gaps:	178/713 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLGALQ 68
            |.|:.....:.|.|.||:....|           .:|:..:.:..||:.|.|
Worm    70 SSVVACYRGTSAESSHSIRRIER-----------VIAINVKSDGSVIKSQIT------------- 110

  Fly    69 LNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLN-SGTFYFA 132
              .|..|.|            |.|..:|.:....   .:..|.|....:.:|.||.| |..|||.
Worm   111 --PGSGTKL------------KQGTEKIMKFFAE---KVTKAEPRPALLDDVLKLFNDSKDFYFC 158

  Fly   133 HTNASASASGASSYRFDITLCAQR---RQQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCG 194
            .:.             |:|:.:|:   :::...:::.||||:.|..:|....|. ..:....|.|
Worm   159 RSR-------------DVTISSQKYFEKREAHTSEDSFFWNKRMVGNLGEAKIS-DKFTCPIMQG 209

  Fly   195 SVEVRTVYIGAKQARA----AIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSY 255
            .|....:.| ..|..|    .||||.|..|||.|:..||.::...||||||||.::.:.....|:
Worm   210 YVATSQLEI-TDQINAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSF 273

  Fly   256 VQTRGSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKE 320
            ||.|||:|:||.|.|.:.....: ::|..|.:...|..|...::..|.    ..|:..|||..:.
Worm   274 VQCRGSIPVFWSQRGFKYRPPLI-INRSVEETHGVFTEHFKRLKAHYD----TPLVAVSLVDQRG 333

  Fly   321 GEAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNFSAL----AKLKERIVACGANYGVFHASN 381
            .|..|:..|..|...:...||....||.||.|||.||..|    :.::|.:...|.   .:....
Worm   334 RELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGF---CWVDKT 395

  Fly   382 GQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQ----MW 442
            |:|::.|.|||||||:|||||||.||..:.|..:..|.:.|.:.|.   :....|:..|    ||
Worm   396 GEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGIFGP---LCEPPEVLVQTMQTMW 457

  Fly   443 INNGNEVSKIYAGTGAIQGG------SKLM----DGARSAARTIQNNLLDNSKQEAIDVLLVGST 497
            .:||:.:|..||||.|::|.      .|||    ||..||:|....:..|..:|:||:: :.|.|
Worm   458 ADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINI-VTGQT 521

  Fly   498 LSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSL 562
            .:.|.|:.     ..|.......:.| :.....:::.|....|                     :
Worm   522 EADENAEE-----EENEKEEEENISR-MVTETIQFLVPTQQTV---------------------I 559

  Fly   563 ADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQK 627
            |.|           .|::....|:.:|           .:|.|..||:
Worm   560 AGW-----------GLINAFQSSDEID-----------TVVILTRSNL----------------- 585

  Fly   628 TISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHG 690
                    .::||:          |..|....::.||::.:.|...|.:||...||....|.|
Worm   586 --------YIVTYE----------IDGEKMTDVQIVALEDINTIQTGTSGNNRQCARLETLEG 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	81/299 (27%)
		INPP5c_Synj	538..863	CDD:197323	24/153 (16%)
		DUF1866	862..1008	CDD:286093
sac-2	NP_001252206.1	COG5329	25..520	CDD:227637	149/517 (29%)
sac-2	NP_001252206.1	hSac2	549..>615	CDD:372122	18/143 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920