DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and figo-1

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_492266.2	Gene:	figo-1 / 172620	WormBaseID:	WBGene00007912	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	162/702 - (23%)
Similarity:	273/702 - (38%)	Gaps:	188/702 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KVCDAYGCLGALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQ----NAAPNEDK 116
            :..:|:|.||.::...|    .:|:::|...::..:|...:::|.:...:.:.    :.:..|.|
Worm    86 RATNAFGILGCVRFVEG----YYLIIITRAHAVATLGYHPVYKIVEVAMIPIAMDGVSTSSEEQK 146

  Fly   117 ISEVRKLLNSGT-FYFAHTNASASASGASSYRFDITLCAQRRQQTQETDNRFFWNRMMHIHLMRF 180
            ..::.:.::..| |||:::...:.....:|.|.|.....|||   .|.|.||.||..: :..:|.
Worm   147 YVKLFQSVDLSTDFYFSYSYDMSRTFQENSLRSDWNNHGQRR---LEADERFVWNSFL-LEPLRK 207

  Fly   181 GIDCQSWLLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQV 245
            .:..:.|.::.:.|.|....:::...:....||.|.|.:.|||||..||.|..|.|||:|||||:
Worm   208 NLISERWFVEIVHGYVRQEYIFLPIGRISLTIIGRRSTKYAGTRFLKRGANPTGNVANYVETEQI 272

  Fly   246 IY--------VDGDVTSYVQTRGSVPLFWEQ----------PGVQVGSHKVKLSRGFETSAAAFD 292
            ::        .||..:|:||.|||||:.|.|          |.:.:.:|        |..|....
Worm   273 VWDMASSGNVADGRFSSFVQMRGSVPMRWSQDPSTRGVVGKPLILIDNH--------EPHAQTAA 329

  Fly   293 RHMSMMRQRYGYQTVV-NLLGSSLVGSKEGEAMLSNEFQRHHG----------------MSAHKD 340
            .|...:|.:||...|: ||:             ..||.:||.|                :...:.
Worm   330 SHFRDVRNKYGNPIVIMNLI-------------KRNEKRRHEGVLHTQFLKNIEYLNQFLPNEEK 381

  Fly   341 VPHVVFDYHQECRGGN---------------------------FSALAKLKERIVACGANYGVFH 378
            :.::.||..:..:..|                           |.....||.|.....|.....|
Worm   382 LCYISFDVARCNKAANSMPSINVLNVMEDLSMKSILKNGWFQSFPLSEALKIRPREAFATLDAHH 446

  Fly   379 ASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFR---Q 440
            :.:|:.: .|.|:.||||:|||||||..|..:....||.||.|:.: ..:.|::...|:.|   .
Worm   447 SKDGRFM-IQHGICRTNCVDCLDRTNVAQFVIAKVALGCQLCAMGI-LDEPNLTLQSEVCRLLED 509

  Fly   441 MWINNGNEVSKIYAG------------TGAIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLL 493
            |:..:|:.::..|||            |.|.|  .:..|..::.:|...|...|..||.||::.|
Worm   510 MFDEHGDTMALQYAGSQLVHSIKTYKKTAAFQ--ERRRDVFQTLSRYYSNTFNDWDKQMAINLFL 572

  Fly   494 VGSTLSSELADRARILLPSNM--------LHAPTTVLRELCKRYTEYVRPRMAR----------- 539
            .        ..|.||....|:        ||.|.::     |..|:|....::.
Worm   573 G--------VFRPRITTMKNLWDLTSDYNLHFPYSL-----KINTDYCAWTLSEKELEDLVFLDY 624

  Fly   540 ---------VAVGTYNVNG-----GKHFRSIVFKDSLADWLLDCHALARSKALVD-------VNN 583
                     |.:.:.:|:|     |..:|:::|  |..:...|.|......:|.|       :.|
Worm   625 DESENSDGYVEIRSIDVDGRRGSEGSEYRTLLF--SSHEDFRDYHRTYEFTSLDDRIGRLFSIEN 687

  Fly   584 PSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLW--AEELQKTISRDN 633
            .:..||        |..|....:|..:        |||  .|..:|...:.|
Worm   688 RAIQVD--------GINEEPTTHAQFL--------KLWKTTETKEKDQKKPN 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	81/331 (24%)
		INPP5c_Synj	538..863	CDD:197323	23/130 (18%)
		DUF1866	862..1008	CDD:286093
figo-1	NP_492266.2	Syja_N	91..394	CDD:367065	81/331 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920