DRSC/TRiP Functional Genomics Resources

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Protein Alignment Synj and Inpp5j

DIOPT Version :10

Sequence 1:NP_569729.1 Gene:Synj / 37517 FlyBaseID:FBgn0034691 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_766027.2 Gene:Inpp5j / 170835 MGIID:2158663 Length:1003 Species:Mus musculus


Alignment Length:594 Identity:148/594 - (24%)
Similarity:230/594 - (38%) Gaps:153/594 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   593 DIYAIGFEEIVDLNASNIM-AASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEH 656
            |:.|||.:|:..:....:. |..||.   |:|.....:...| :||::..::.||.|.::.:..|
Mouse   454 DMIAIGLQEVNSMINKRLKDALFTDQ---WSELFMDALGPFN-FVLVSTVRMQGVILLLFAKYYH 514

  Fly   657 APHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKL 721
            .|.:|||..||.:|||||..||||..::|....|..:||:..|..|...:..:|..::..|....
Mouse   515 LPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQ 579

  Fly   722 AF--PMGRTLKSHDWVFWCGDFNYRID-MEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEF 783
            .|  |....:..||.|||.||.|:||: .:...:|..:.:..|..:.|.|||...:....:...|
Mouse   580 QFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGF 644

  Fly   784 LEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKL---IHYG 845
            .||.:.|.||:|:|:.::.||||.|:|.||||||:||:.:  ...|..:.|.....:|   .|..
Mouse   645 QEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVK--APSGGPSPSGRESHRLQVTQHSY 707

  Fly   846 RSELKQ--SDHRPVIAII--------DAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHVLES-S 899
            ||.::.  |||:||.|..        |..::.:          :|..:...|:..:|.:.:|: .
Mouse   708 RSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRL----------EVADEWARPEQAVVRYRVETVF 762

  Fly   900 ATGDEDGPTIY---------------------DENVMSALITELS---KMGEVTLVRY------- 933
            |....|...:|                     |.|:.....:|.|   ..|:..|..|       
Mouse   763 ARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSIL 827

  Fly   934 --VEDTMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPV 996
              |.:...::....|||.:::........|.|              ||.:||..           
Mouse   828 IGVTEPFQISLPTSESASSSTDSSGTSSEGED--------------DSTLELLA----------- 867

  Fly   997 EHAQLLQAITPELPQRPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPP-------- 1053
                                   |.:|.|   ||..|.||......::..|..|..|        
Mouse   868 -----------------------PKSRSP---SPGKSKRHRSRSPGLARFPSLALHPSSRERRGG 906

  Fly  1054 -MPPQPQSQPLIPSPLQPQVAPPRPPAMDTTPSSKSQSPTELVSASSSTSSSGKTSPTA-PAVLS 1116
             ..|.|||:.|      |:|||.|                   ..|||:..|.:..|:. |...:
Mouse   907 SRSPSPQSRQL------PRVAPDR-------------------GHSSSSRGSSEEGPSGLPGPWA 946

  Fly  1117 GPPTPPRQM 1125
            .||:.||.:
Mouse   947 FPPSVPRSL 955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynjNP_569729.1 COG5329 61..493 CDD:227637
INPP5c_Synj 538..863 CDD:197323 92/286 (32%)
DUF1866 862..1008 CDD:286093 25/179 (14%)
Inpp5jNP_766027.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..110
RSXSXX motif 1 6..11
PHA03247 <50..337 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..414
SH3-binding. /evidence=ECO:0000255 346..351
RSXSXX motif 2 351..356
INPP5c_INPP5J-like 420..727 CDD:197328 92/278 (33%)
Catalytic. /evidence=ECO:0000255 422..725 92/276 (33%)
Required for ruffle localization 726..837 16/120 (13%)
SKICH 738..836 CDD:465482 15/107 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..1003 40/193 (21%)
RSXSXX motif 3 871..876 3/7 (43%)
RSXSXX motif 4 882..887 0/4 (0%)
RSXSXX motif 5 908..913 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

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