DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Inppl1

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001116211.1	Gene:	Inppl1 / 16332	MGIID:	1333787	Length:	1257	Species:	Mus musculus

Alignment Length:	864	Identity:	205/864 - (23%)
Similarity:	314/864 - (36%)	Gaps:	255/864 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 ARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRAR----ILLPSNMLHAPTTVLRELCKRYTEYV 533
            ::.:||.|              |.....| .||.:    |.:.:....|...:|:.:..|:::..
Mouse   371 SQRVQNKL--------------GVVFEKE-KDRTQRKDFIFVSARKREAFCQLLQLMKNRHSKQD 420

  Fly   534 RPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIG 598
            .|.|..|.:||:|:.      |:....::..|..   :....|||.:|     .|..|.|||..|
Mouse   421 EPDMISVFIGTWNMG------SVPPPKNVTSWFT---SKGLGKALDEV-----TVTIPHDIYVFG 471

  Fly   599 FEEIVDLNASNIMAASTDNAKLWAEELQKTISR--DNDYVLLTYQQLVGVCLYIYIRPEHAPHIR 661
            .:|            ::...:.|.:.|:..:..  |.||..:..|.|..:.:.:.::|||...|.
Mouse   472 TQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRIS 524

  Fly   662 DVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMG 726
            .|:...||||:....|||||..:.|:.:|||..||..|..:|..:...||.:|.:|.|.|:  :|
Mouse   525 HVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDILRLLS--LG 587

  Fly   727 -RTLKSHD------WVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFL 784
             |.|.:.|      .:||.||.|||:||:..|:...:...:...:|..|||..|:|...||..|.
Mouse   588 DRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPLLRVDQLNLEREKHKVFLRFS 652

  Fly   785 EGEITFDPTYKYDLFSDDYDTSEKQR-------APAWTDRVLWRRRKALAEGDFAASAWNPGKLI 842
            |.||:|.|||:|:..|.|.....||:       .|:|.||:||   |:..|.....::
Mouse   653 EEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILW---KSYPETHIICNS------- 707

  Fly   843 HYG-RSELKQSDHRPVI-----------------------AIIDAEIME-IDQQRRRAVF----- 877
             || ..::..|||.||.                       |.|:.|.:| |.:...|..|
Mouse   708 -YGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFY 771

  Fly   878 --------EQVIRDLGPPDSTIVVHVLESS-----------------------ATGDEDGPTIYD 911
                    :....|....|:...:.|..||                       .....||...|.
Mouse   772 STCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYG 836

  Fly   912 ENVMS----------ALITELSKMGEVT-------LVRYVEDTM--------WVTFRDGESALNA 951
            |.|::          ..:|.||..||.|       .||...:.:        |::....::  .|
Mouse   837 ECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDT--GA 899

  Fly   952 SSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQLLQAITPELPQRPKQP 1016
            .||          :..:.....:|...|.....|..:.||               .:|.:.|::|
Mouse   900 KSK----------VPSVSRGSQEHRSGSRKPASTETSCPL---------------SKLFEEPEKP 939

  Fly  1017 PTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMPPQPQSQPLIPSPLQPQVAPPRPPAMD 1081
            |  |..|||.|      ||.:|.       .:|..|.:..:..|:       |..||.|.|....
Mouse   940 P--PTGRPPAP------PRAVPR-------EEPLNPRLKSEGTSE-------QEGVAAPPPKNSF 982

  Fly  1082 TTPS--SKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPTRQVGSPK 1144
            ..|:  .....|.:|:             |..|..|:..|.||   .:|....::.|..|:|..:
Mouse   983 NNPAYYVLEGVPHQLL-------------PLEPPSLARAPLPP---ATKNKVAITVPAPQLGRHR 1031

  Fly  1145 DPIPSDTAYETASNIYEEIQEDVPAPRHPPPAGPP--------------PVI-----GAPMGPPP 1190
            .|...:     .|:..|:....:|.|..|||..|.              ||:     |...||||
Mouse  1032 TPRVGE-----GSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSGGEARGPPP 1091

  Fly  1191 PLPNRRGPPPIPNRSGNAP 1209
            |..:.|  ||:|  .|.:|
Mouse  1092 PKAHPR--PPLP--PGTSP 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	104/364 (29%)
		DUF1866	862..1008	CDD:286093	32/207 (15%)
Inppl1	NP_001116211.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	102/341 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986		28/137 (20%)
		SH3-binding	945..950		3/10 (30%)
		NPXY motif	984..987		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1119		33/120 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1134..1196
		SAM_Ship2	1193..1255	CDD:188890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740