DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and Inpp5d

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_006529212.1	Gene:	Inpp5d / 16331	MGIID:	107357	Length:	1196	Species:	Mus musculus

Alignment Length:	894	Identity:	202/894 - (22%)
Similarity:	319/894 - (35%)	Gaps:	286/894 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 VLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRS 555
            |:|| .|...::..:..:...|........:|:::..:::|...|.|..:.:||:|:......:.
Mouse   361 VILV-ETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKK 424

  Fly   556 IVFKDSLADWLLDCHALARSKALVDVNNPSENVDH-PVDIYAIGFEEIVDLNASNIMAASTDNAK 619
            |      ..|.|       ||.  ......::.|: |.|||.||.:|            .....|
Mouse   425 I------TSWFL-------SKG--QGKTRDDSADYIPHDIYVIGTQE------------DPLGEK 462

  Fly   620 LWAEELQKTISRDNDYVLLT--YQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGAC 682
            .|.|.|:.::.........|  ...|..:.:.:..:|||...|..:..|.||||:....|||||.
Mouse   463 EWLELLRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAV 527

  Fly   683 AIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAF------PMGRTLK-SHDWVFWCGD 740
            .:.|:.:|||:.||.:|..:|..:...||.:|..|.|.||.      |...|.: :|  :||.||
Mouse   528 GVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTH--LFWLGD 590

  Fly   741 FNYRIDM---EKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDD 802
            .|||:::   |.:.:.:.::....|.:|..|||..|::...||..|.|.||||.|||:::..:.|
Mouse   591 LNYRVELPTWEAEAIIQKIKQQQYSDLLAHDQLLLERKDQKVFLHFEEEEITFAPTYRFERLTRD 655

  Fly   803 YDTSEKQRA-------PAWTDRVLWRRRKALAEGDFAASAWNPGKLIH-----YG-RSELKQSDH 854
            .....||:|       |:|.|||||:..                .|:|     || .|::..|||
Mouse   656 KYAYTKQKATGMKYNLPSWCDRVLWKSY----------------PLVHVVCQSYGSTSDIMTSDH 704

  Fly   855 RPVIAIIDAEIME---------------IDQQ--------------RRRAVF------------- 877
            .||.|..:|.:..               :|.|              :.:..|
Mouse   705 SPVFATFEAGVTSQFVSKNVSHAPGPGTVDSQGQIEFLACYATLKTKSQTKFYLEFHSSCLESFV 769

  Fly   878 -------------EQVIR------DLGP----PDSTIVVHVLESSATGDEDGPTIYDENVMS--- 916
                         |.|:|      .|.|    |:..:..|:|.|..:.|.|  ..|.|..::
Mouse   770 KSQEGENEEGSEGELVVRFGETLPKLKPIISDPEYLLDQHILISIKSSDSD--ESYGEGCIALRL 832

  Fly   917 -------ALITELSKMGEVTLVRYVEDTMWVTFRDGESALNASSKK------------SIQVCGL 962
                   .:.|.|:..||:|          ..|| ||..|..|..|            ..:..|:
Mouse   833 ETTEAQHPIYTPLTHHGEMT----------GHFR-GEIKLQTSQGKMREKLYDFVKTERDESSGM 886

  Fly   963 DLILELKSKD----WQHLVDSEIELCTTNTIPLCANP-----------------VEHAQLLQAIT 1006
            ..:..|.|.|    |:  ....:..|..:::....||                 :...|.|.|.:
Mouse   887 KCLKNLTSHDPMRQWE--PSGRVPACGVSSLNEMINPNYIGMGPFGQPLHGKSTLSPDQQLTAWS 949

  Fly  1007 -PELPQ-------RPKQPPTRPPARPPMPMSPKN----------SPR------------------ 1035
             .:||:       |.:.||| ||::|  |:|||.          .||
Mouse   950 YDQLPKDSSLGPGRGEGPPT-PPSQP--PLSPKKFSSSTANRGPCPRVQEARPGDLGKVEALLQE 1011

  Fly  1036 ----------HLPHVGVISIVPK--PAK----PPM-----PPQPQSQPLIPSPLQPQVAPPRPPA 1079
                      ..|..|.:|..||  |.|    |.|     ||.|.     |....|.:..|:...
Mouse  1012 DLLLTKPEMFENPLYGSVSSFPKLVPRKEQESPKMLRKEPPPCPD-----PGISSPSIVLPKAQE 1071

  Fly  1080 MDTTPSSKSQSPTELV-------SASSSTSSSGK--------------TSPTAPAVLSGPPTPPR 1123
            :::...:..|:|..::       |.:.|:|:.|:              .|..||..:..|..|.|
Mouse  1072 VESVKGTSKQAPVPVLGPTPRIRSFTCSSSAEGRMTSGDKSQGKPKASASSQAPVPVKRPVKPSR 1136

  Fly  1124 QMQSKQATPVSTPTRQVGSPKDPIPSDTAYETASNIYEEIQEDVPAPRH 1172
            ...|:|.||:..|     .|..|:.|....:...:...:.:::...|.|
Mouse  1137 SEMSQQTTPIPAP-----RPPLPVKSPAVLQLQHSKGRDYRDNTELPHH 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	101/350 (29%)
		DUF1866	862..1008	CDD:286093	40/254 (16%)
Inpp5d	XP_006529212.1	SH2_SHIP	4..105	CDD:198206
Inpp5d	XP_006529212.1	INPP5c_SHIP1-INPP5D	407..713	CDD:197334	101/350 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740