Protein Alignment Synj and Inpp5b

DIOPT Version :10

• Sequence 1: NP_569729.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_006502867.1
• Gene: Inpp5b / 16330
• MGIID: 103257
• Length: 994
• Species: Mus musculus
• Alignment Length: 609
• Identity: 174/609 - (28%)
• Similarity: 274/609 - (44%)
• Gaps: 93/609 - (15%)

  Fly   468 GARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEY 532
            |||...:. :|:|...:|.:: |:.....:.:..::|:|.||.........|.|...|.::...|
Mouse   278 GARCPEKP-ENSLTRQNKSKS-DMSEKVRSATVTVSDKAHILSVQKFGLRDTIVRSHLVQKEENY 340

  Fly   533 VRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCH-ALARSKALVDVNNPSENVDHPVDIYA 596
            ...:..|..||||||||...      |:.|..||  .| |||                  .|:|.
Mouse   341 TYIQNFRFFVGTYNVNGQSP------KECLRPWL--SHSALA------------------PDVYC 379

  Fly   597 IGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIR 661
            :||:|: ||:........|...:.|.:.:.:::..|..|..:.:.:|||:.|.:|::.|||.:|.
Mouse   380 VGFQEL-DLSKEAFFFHDTPKEEEWFKAVSESLHPDAKYAKVKFVRLVGIMLLLYVKQEHAAYIS 443

  Fly   662 DVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPM- 725
            :|..:.|.||:.|..||||..||||.||.||:|.|.:|.||...:...||.||.:|..::.||.
Mouse   444 EVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSHLAAHTEEYERRNQDYRDICSRMQFPQV 508

  Fly   726 -----GRTLKSHDWVFWCGDFNYRI-DMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFL 784
                 ..|:..||.:.|.||.|||| :::..::|:.|......|:...|||:.:..|..:|..|.
Mouse   509 DPSQPPLTINKHDVILWLGDLNYRIEELDVGKVKKLVEEKAFQTLYAHDQLKIQVAARTIFDGFT 573

  Fly   785 EGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHYGRSEL 849
            ||||||.||||||..|||:|||||.|||||.||:||:.:             |..:|.:.....|
Mouse   574 EGEITFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-------------NITQLSYQSHMAL 625

  Fly   850 KQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHVLESSATG----------DE 904
            |.|||:||.::.|..:..::::..|...|:::|.|...::..:..|..|....          ..
Mouse   626 KTSDHKPVSSVFDIGVRVVNEELYRKTLEEIVRSLDKMENANIPSVTLSKREFCFENVKYMQLQT 690

  Fly   905 DGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESALNASSKKSIQV---------- 959
            :..||::..| ......::|..|.:..:     .|:|.|..:..|...|...|::
Mouse   691 ESFTIHNSQV-PCQFEFINKPDEESYCK-----QWLTARPSKGFLLPDSHVEIELELFVNKSTAT 749

  Fly   960 ---CGLD-----LILEL-KSKDWQHLVDSEIELCTTNTIPLC-ANPVEHAQLLQAITPELPQRPK 1014
               .|.|     |:|.| :.||:...|..       |.:|.| .:|:.....::....:||.:..
Mouse   750 KLNSGKDTIEDILVLHLERGKDYFLSVSG-------NYLPSCFGSPIHTLCYMREPILDLPLKTV 807

  Fly  1015 QPPTRPPARPPMPMSPKNSPRHLP 1038
            ...|....:.....|...:|..:|
Mouse   808 SDLTLMSVQTADDRSQLENPMEIP 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_569729.1	COG5329	61..493	CDD:227637	7/24 (29%)
		INPP5c_Synj	538..863	CDD:197323	123/332 (37%)
		DUF1866	862..1008	CDD:286093	30/175 (17%)
Inpp5b	XP_006502867.1	INPP5B_PH	1..147	CDD:465268
		INPP5c_INPP5B	346..639	CDD:197327	123/332 (37%)
		RhoGAP_OCRL1	773..991	CDD:239845	11/66 (17%)