DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlcT and UGCG

DIOPT Version :9

Sequence 1:	NP_611636.1	Gene:	GlcT / 37516	FlyBaseID:	FBgn0067102	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_003349.1	Gene:	UGCG / 7357	HGNCID:	12524	Length:	394	Species:	Homo sapiens

Alignment Length:	395	Identity:	208/395 - (52%)
Similarity:	272/395 - (68%)	Gaps:	7/395 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHLPLPLYGFAAFFMVFWLGTWMVHVIAICYGRYKLHKKSCKLPTEAQP---LPGVSILKPLMG 62
            |:.|.|.|.|.|.|..|.:|..|::|.:||.|.|..|:||:    |:.||   |||||:||||.|
Human     1 MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKA----TDKQPYSKLPGVSLLKPLKG 61

  Fly    63 VDPNLQHNLETFFTMDYPLYELLFCVEDKEDPAIQLVERLLAKYPLVDAALFVGGSDVGVNPKIN 127
            |||||.:||||||.:|||.||:|.||:|.:||||.:.::||.|||.|||.||:||..||:|||||
Human    62 VDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKIN 126

  Fly   128 NIHPGYMAAKYDFVMISDSGIKMKDDTLLDMVQNMSEKHALVHQMPFTCDRDGFAATFEKVFFGT 192
            |:.|||..||||.:.|.||||::..|||.|||..|:||..|||.:|:..||.|||||.|:|:|||
Human   127 NLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGT 191

  Fly   193 VQSRIYLSADVLGINCHTGMSCLLRKAVIDQLGGLRAFGCYLAEDFFIARSVTRLGWKMRISNQP 257
            ...|.|:||:|.|..|.||||||:||.|:||.|||.||..|:|||:|:|:::...||:..:|.|.
Human   192 SHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQV 256

  Fly   258 ALQNSGLCDIGSFQARLIRWAKLRVAMVPTTILLEPLSECMILGAIAAWSASVLFSWDPLVFYLV 322
            |:||||...|..||:|:|||.|||:.|:|.||:.||:|||.:...|..|:|..:|.||.:||::.
Human   257 AMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMC 321

  Fly   323 HVLCWFLSDWLLLSIVQHGSMPFHKFEFVVGWLFRELTGPYLFLHALWNPAIRWRARTYKLHWGG 387
            |.|.||:.|::.|..||.|::.|.|.::.|.|..||....|:||.|||:|.|.||...|:|..||
Human   322 HCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGG 386

  Fly   388 VAYEL 392
            .|.|:
Human   387 TAEEI 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlcT	NP_611636.1	BcsA	4..399	CDD:224136	207/392 (53%)
GlcT	NP_611636.1	Glucosylceramide_synthase	52..281	CDD:133012	136/228 (60%)
UGCG	NP_003349.1	Glucosylceramide_synthase	51..280	CDD:133012	136/228 (60%)
UGCG	NP_003349.1	(Q/R)XXRW. /evidence=ECO:0000305	272..276		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152762
Domainoid	1	1.000	211	1.000	Domainoid score	I2812
eggNOG	1	0.900	-	-		E1_COG1171
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37763
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1729
Isobase	1	0.950	-	0	Normalized mean entropy	S3069
OMA	1	1.010	-	-		QHG52929
OrthoDB	1	1.010	-	-		D344338at33208
OrthoFinder	1	1.000	-	-		FOG0004917
OrthoInspector	1	1.000	-	-		oto90284
orthoMCL	1	0.900	-	-		OOG6_104675
Panther	1	1.100	-	-	LDO	PTHR12726
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3247
SonicParanoid	1	1.000	-	-		X4017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750