Protein Alignment KCND2 and Task6

DIOPT Version :10

• Sequence 1: NP_036413.1
• Gene: KCND2 / 3751
• HGNCID: 6238
• Length: 630
• Species: Homo sapiens
• Sequence 2: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 81/404 - (20%)
• Similarity: 142/404 - (35%)
• Gaps: 136/404 - (33%)

Human   124 LIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHTSTMAL--- 185
            |:...:.|....|.:.||   .|.|||      |.:..:......|..::..|     |:.|
  Fly    20 LVGAAVFDALESETEKRR---WEALQD------AEDMIIRKYNISQEDFKVME-----TVVLKSE 70

Human   186 ------------VFYYVTGFFIAVSVIANVVETVPCG-SSPGHIKELPCGERYAVAFFCLDTACV 237
                        .|||.|          .|:.|:..| |:|                   .|...
  Fly    71 SHKAGQQWKFTGAFYYAT----------TVLTTIGYGHSTP-------------------STVGG 106

Human   238 MIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFR-IF 301
            .:||:.|                        ||:...:||||..:       :..||.|:.. :.
  Fly   107 KLFTMCY------------------------AIVGIPLGLVMFQS-------IGERVNRLSSYVI 140

Human   302 KFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIV 366
            |..|.|...:      ::.|||:..:....|::.:..|.......|....|.|.|:    :|..:
  Fly   141 KAVRSSLRCK------RTVASEVDLICVVTTLSSLTIAGGAAAFSKFEGWSYFDSV----YYCFI 195

Human   367 TMTTLGYGDMV-----------PKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 420
            |:||:|:||||           |:.:   :|..|..|.|:.::|..:.::|..|..:..:::|.|
  Fly   196 TLTTIGFGDMVALQRDNALNRKPEYV---MFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRD 257

Human   421 KRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCL 485
            :.:|.:..::|........::|..:.|...|         .|.|:....:.||..:     .||:
  Fly   258 EAQAMQALQVAVKLEGDVITSNGSILSGYEG---------HDGQSLNGSNTSSMCS-----CHCI 308

Human   486 -------EKTTNHE 492
                   :|::|.|
  Fly   309 CLNGNRHKKSSNLE 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND2	NP_036413.1	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881	2..20
		BTB_POZ	6..144	CDD:453885	5/19 (26%)
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881	71..90
		Ion_trans	184..415	CDD:459842	52/258 (20%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321		0/12 (0%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		2/4 (50%)
		DUF3399	470..546	CDD:463381	7/30 (23%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881, ECO:0000305|PubMed:16934482	474..630		5/26 (19%)
		Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..630
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881	627..630
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	19/113 (17%)
		Ion_trans_2	165..243	CDD:462301	21/84 (25%)