Protein Alignment PEAR1 and drpr

DIOPT Version :9

• Sequence 1: XP_016856723.1
• Gene: PEAR1 / 375033
• HGNCID: 33631
• Length: 1125
• Species: Homo sapiens
• Sequence 2: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Alignment Length: 1055
• Identity: 346/1055 - (32%)
• Similarity: 474/1055 - (44%)
• Gaps: 176/1055 - (16%)

Human   160 YRTVYRQV--VKTDHRQRL--QCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCS 220
            ||..:|.|  .||..:.|:  .||.|:..|.|.|||.|::.|.||||::|.:|:|..|:.|..|.
  Fly    65 YRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACD 129

Human   221 SECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQC-HGA 284
            ..|.||.:|..|...|.|.||:.|:|.||.|.|..|.....|...|..|::|..|..:|:| :|.
  Fly   130 INCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGG 194

Human   285 PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSL 349
            .|...:|.|.|....|||.||:.|..|..|..|.....|||.|..|...|:|.|.|||.|.:|:.
  Fly   195 KCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCAN 259

Human   350 PCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDAR 414
            .||.|.:||.|.:.|.|:.|..|...||||.|.|||.|:||.:||.:..:|.:|:.|||||.||.
  Fly   260 KCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAM 324

Human   415 CFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHC 479
            |..|||.|:|..|:||.:|.:|:|....|||.|...|.||.||:..|||..|.|.|..||:...|
  Fly   325 CDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQC 389

Human   480 NESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 544
            ...|....:||.|:..|.|.:|..|...:|.|.||||:.||.|...|.|.|:|.:|:.||.|:|.
  Fly   390 TRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNG 454

Human   545 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQ 609
            ..|.|..|:|:|..||:...|..||....:|..|...|.|.:.|.|:||.|:|||..||.|..|:
  Fly   455 AKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCE 519

Human   610 LPCPKGQFGEGCASRCDCD--HSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKN 672
            ..|..|:||..||.:|.||  :|..||..:|||.|:..|.|..|..:|..|.:|.||...|.|.|
  Fly   520 RKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLN 584

Human   673 GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRC------------------------------ 707
            ..:|.|::|||:|:.|:.|..|...|.||.||..|
  Fly   585 NSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGL 649

Human   708 ----------------VPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCH 756
                            :.|.|.:...|:...|.|.||.||||.:|::.||...:|:.|||.|:|.
  Fly   650 TCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCV 714

Human   757 HGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGE-KCHPETGACVCPPGHSGA 820
            |...|...||.|||..||:|..|.|.||.|.:|.:|...|.|.... :||...| |||..|::|.
  Fly   715 HHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGD 778

Human   821 PC-------RIGIQEPFTVMPTTPVAYNSLGAVIGIA-VLGSLVVALV-ALFIGYRHWQKGKEHH 876
            .|       ||..|           :.||..|.:.:. ||.:|...:: |:||.||.
  Fly   779 NCDELIASQRIADQ-----------SENSSRASVALTLVLMTLFACIIFAVFIYYRR-------- 824

Human   877 HLAVAYSSGRLDGSEYVMPDVPPSY--SHYYSNPSYHTLSQCSPNPPPPNKVPGPLFASLQNPER 939
              .|:.....:....|.....|||:  :|.:.||.|...::       ...:|..:.:.:.|
  Fly   825 --RVSNLKTEIAHVHYTHDTNPPSWPPNHNFDNPVYGMQAE-------TRLLPNNMRSKMNN--- 877

Human   940 PGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGPFYNKGLISEEELGASV 1004
                  .|..:|:..|:        |.....|.|:.   |||.:      ||..|:: :.|.|..
  Fly   878 ------FDQRSTMSTDY--------GDDCNASGRVG---SYSIN------YNHDLLT-KNLNADR 918

Human  1005 A-------SLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQR 1062
            .       ||..|:.|..|:         .:..|            :.|.:.:  .:...|:.:.
  Fly   919 TNPIVYNESLKEEHVYDEIK---------HKEGY------------KDPVKIY--SKILFPEDEY 960

Human  1063 DSGTYEQPS----PLIH-----------DRD--------SVGSQPPLPPGLPPGHYDSPKNSHIP 1104
            |...|.:||    |..|           |.:        :|....||||..|...::...|::.
  Fly   961 DHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNT- 1024

Human  1105 GHYDLPPVRHPPSPP 1119
             :.|......|.|.|
  Fly  1025 -NLDNVSTASPSSSP 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEAR1	XP_016856723.1	None
drpr	NP_001261276.1	EMI	27..92	CDD:284877	10/26 (38%)
		EGF_CA	274..319	CDD:304395	21/44 (48%)
		DSL	<479..518	CDD:302925	16/38 (42%)
		DSL	<567..606	CDD:302925	16/38 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5794
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40878
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.690