DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCND1 and Shab

DIOPT Version :10

Sequence 1:NP_004970.3 Gene:KCND1 / 3750 HGNCID:6237 Length:647 Species:Homo sapiens
Sequence 2:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster


Alignment Length:612 Identity:191/612 - (31%)
Similarity:288/612 - (47%) Gaps:118/612 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    28 PPAPGVKA------SRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA--------- 77
            ||.|.:.|      ||    :.:||.|.|.|....||:|.|.|.||...:...::|         
  Fly   293 PPEPFMIAQSKAVNSR----VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYS 353

Human    78 -DSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK- 140
             ...||||||.|..|..:|||||||:||...:.|:.||.::|.::|:....:..||..:|..|| 
  Fly   354 LADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKE 418

Human   141 ------KENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVS 199
                  ::.||.|.:.:| |:.|:|..    :..::.||...|.|:||.||.|...::..||.:|
  Fly   419 NVHEEMRKEAESLRQRDE-EEFGEGKC----AEYQKYLWELLEKPNTSFAARVIAVISILFIVLS 478

Human   200 VIANVVETIPCRGSARRSSREQPCGERFPQ---AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLR 261
            .||..:.|:|         :.|......||   ....::..|:..||.||:||..|:|.:.:|.:
  Fly   479 TIALTLNTLP---------QLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFK 534

Human   262 SVMSLIDVVAILPYYIGLLV---PKN-----DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 318
            ..:::||::|||||::.|.:   .||     .||.......|:.|:.||.|.:|||.||:.||:|
  Fly   535 GGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFT 599

Human   319 LKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTI 383
            |::...|||.|:..|.|.::||:::.::|||....|.|.|||..||:..:||||:||||:.|:|.
  Fly   600 LRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTA 664

Human   384 AGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQ 448
            .||:.|::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.|:..:|  
  Fly   665 LGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSF-- 724

Human   449 YKQNGGLEDSGSGEEQALCVRNRSAFEQQHH-HLLHCLEKTTCHEFTDELT-FSEALGAVSPGGR 511
                                         || :|.....|:.  :..|.:. ..:....|.|.|:
  Fly   725 -----------------------------HHINLKDAFAKSM--DLIDVIVDTGKQTNVVHPKGK 758

Human   512 TSRSTSVSSQPV----GPGSLLSSCCPRRAKRRAIRLANST----------ASVSRGSMQELDML 562
            ...:.::..|.:    .||..||...           .|||          |:...|..:..|.:
  Fly   759 RQSTPNIGRQTLDVQSAPGHNLSQTD-----------GNSTEGESTSGRNPATTGTGCYKNYDHV 812

Human   563 AGLRRSHAPQSR---SSLNAKPHDSLD 586
            |.||.|:....|   |..:|.|..|.|
  Fly   813 ANLRNSNLHNRRGSSSEQDAVPPYSFD 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCND1NP_004970.3 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..143 CDD:453885 46/137 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..163 7/18 (39%)
Ion_trans 185..417 CDD:459842 94/242 (39%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 6/12 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 3/4 (75%)
DUF3399 470..550 CDD:463381 16/95 (17%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 39/111 (35%)
Ion_trans 464..700 CDD:459842 94/244 (39%)
Blue background indicates that the domain is not in the aligned region.

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