DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCND1 and CG1688

DIOPT Version :10

Sequence 1:NP_004970.3 Gene:KCND1 / 3750 HGNCID:6237 Length:647 Species:Homo sapiens
Sequence 2:NP_610516.1 Gene:CG1688 / 36005 FlyBaseID:FBgn0027589 Length:918 Species:Drosophila melanogaster


Alignment Length:501 Identity:106/501 - (21%)
Similarity:161/501 - (32%) Gaps:164/501 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   216 RSSREQPCGERFPQAFFCMDTACVLI---FTGEYLLRLFAAP-----------SRCRFLRSVMSL 266
            |||..:.||......|.......::|   ..|..|..|..||           ||...||.:.  
  Fly    59 RSSLRRCCGHLLKLLFSTPGLVLLVIGYSVLGGLLFPLLEAPQDISKSAAIAKSREDCLRELW-- 121

Human   267 IDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIF---------KFSRHSQGLRILGYTLKSC 322
                 |:...:.:|..:|       .|:.|....|.|         :.|..|.|....|...:..
  Fly   122 -----IITEKLNVLYERN-------WTMLVHEQLRRFEGSIVAATRQGSAGSSGGGGAGLFHEGS 174

Human   323 ASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKI 387
            ||.||.                |..:.|.:::  .|...|..|::..:||:|:|.:.|.|.|||:
  Fly   175 ASALGH----------------FGYDAGDSQS--WSFSEALLYSVTVITTIGHGSLTPRTAAGKL 221

Human   388 FGSICSLSGVLVI--------ALPVPVIVSNFSRIYHQNQRADKRR------------------- 425
            .....:|.||.::        ||....:...:.|:..|.||..:.|                   
  Fly   222 ATIFYALVGVPLMLMCLSSLGALLADGLQCTYVRLCCQLQRHQEHRRKSTPGTSTPSASSAANSR 286

Human   426 -----AQQKVRLARIR-----LAKSGTT-NAFLQYKQNGGL-EDSGSGEEQALCVRNRSAFEQQH 478
                 .:.|.|:|..:     .|.|.|: |..|:|.|.|.| .|...|:   .|...|:...|||
  Fly   287 EKDTDKRSKRRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGD---ACQLLRNLNPQQH 348

Human   479 HHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGP---------GSLLSSCCP 534
            .:                                   .....||..|         ||.|....|
  Fly   349 FY-----------------------------------QQQQQQPQQPDVMLMTTTSGSALLKYAP 378

Human   535 RRAK-RRAIRLANSTASVSRGSMQELDMLAGLRRSH--APQS--RSSLNAKPHDSLDLNCDSRDF 594
            ::.: ::..:|:.:|.......||.......|:::.  .|.|  |..|...|      ||    :
  Fly   379 QQQQLQQQQQLSTATLPRQHHQMQLQQQQQQLQQNFVAVPSSMLRMPLTVPP------NC----Y 433

Human   595 VAAIISIPTPPANTPDESQPSSPGGG------GRAGSTLRNSSLGT 634
            ..|..:|..|..:.|  |.|.||...      ...|:.|.|::||:
  Fly   434 APATATIYFPFGHAP--SAPGSPAHNQAHPTQNPNGNALGNTTLGS 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCND1NP_004970.3 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..143 CDD:453885
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..163
Ion_trans 185..417 CDD:459842 51/231 (22%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 2/12 (17%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 2/4 (50%)
DUF3399 470..550 CDD:463381 13/89 (15%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634 11/38 (29%)
CG1688NP_610516.1 Ion_trans_2 177..247 CDD:462301 21/87 (24%)
Ion_trans_2 822..896 CDD:462301
Blue background indicates that the domain is not in the aligned region.

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