DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCND1 and Shaw

DIOPT Version :10

Sequence 1:NP_004970.3 Gene:KCND1 / 3750 HGNCID:6237 Length:647 Species:Homo sapiens
Sequence 2:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster


Alignment Length:648 Identity:209/648 - (32%)
Similarity:292/648 - (45%) Gaps:148/648 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    42 LVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHC 105
            :|:||.|.|.||:|.||.:.|.|.|.. :|....||....||||||.|.:|..|||:||||:||.
  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHY 91

Human   106 PRQECIQAFDEELAFYGLVPELVGDCCLEEYR------------DRKKENAERLAEDEEAEQAGD 158
            |...|...|:|||.|:||....|..||...|.            ||...:.|:.:|:|.|.:.|.
  Fly    92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGF 156

Human   159 GPALPAGS-----SLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP--------- 209
            ......|:     .::.|:|..|:.|::|.||.....|:.|||.:|:::..::|.|         
  Fly   157 EEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRN 221

Human   210 -----CRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDV 269
                 ..||......:.......  |||.::..|...||.|.|:|..::|::..|::|.:::||.
  Fly   222 ITVKTANGSNGWFLDKTQTNAHI--AFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDY 284

Human   270 VAILPYYIGLLVPK------NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 328
            :|.|.:||.|::.:      |.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||..
  Fly   285 IATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKELTL 346

Human   329 LLFSLTMAIIIFATVMFYAEK-GTNKTN-FTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391
            |:|.|.:.|:|||::::|||: ..|..| |.|||...|:.:|||||:|||||.|.|..|...|::
  Fly   347 LVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGAL 411

Human   392 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLE 456
            |:|:|||.||||||||||||:..|...|             ||.:|.|.                
  Fly   412 CALAGVLTIALPVPVIVSNFAMYYSHTQ-------------ARAKLPKK---------------- 447

Human   457 DSGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVS-- 519
                 ..:.|.|      ||.....|.                    ||  |||.:...|..|  
  Fly   448 -----RRRVLPV------EQPRQPRLP--------------------GA--PGGVSGCGTPGSGP 479

Human   520 -SQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHD 583
             |.|:|.|    ...|||...:...|. |..||::       :.||      |...|.:...|..
  Fly   480 HSGPMGSG----GTGPRRMNNKTKDLV-SPKSVAQ-------LFAG------PLGASIVAMSPRT 526

Human   584 SLDLNCDSRDFVAAII--------SIPTPPANTPDESQPSSPGGGGRA---GSTLRNSSLGTP 635
            .||||       .|:.        .||||.|.||  ..|.|..||..|   |:|....:...|
  Fly   527 MLDLN-------PALAMGKPTFQPRIPTPLAATP--PPPVSSAGGMTASGIGTTSATGATSAP 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCND1NP_004970.3 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..143 CDD:453885 48/113 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..163 5/18 (28%)
Ion_trans 185..417 CDD:459842 96/253 (38%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 5/12 (42%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 3/4 (75%)
DUF3399 470..550 CDD:463381 19/82 (23%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634 14/35 (40%)
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 46/107 (43%)
Ion_trans 188..439 CDD:459842 96/255 (38%)
PRK14959 <418..>585 CDD:184923 67/252 (27%)
Blue background indicates that the domain is not in the aligned region.

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