Protein Alignment KCND1 and Sh

DIOPT Version :10

• Sequence 1: NP_004970.3
• Gene: KCND1 / 3750
• HGNCID: 6237
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 425
• Identity: 160/425 - (37%)
• Similarity: 242/425 - (56%)
• Gaps: 61/425 - (14%)

Human    40 EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRT-GR 102
            |.:|:||||.||||...||:::||||||...:.. ::|....||||||....|..:|.:|:: ||
  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161

Human   103 LHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK---KENAERLAEDEEAEQAGDGPALPA 164
            |..|....:..|.||:.||.|     ||..:.::|:.:   ||....|.::|:
  Fly   162 LRRPVNVPLDVFSEEIKFYEL-----GDQAINKFREDEGFIKEEERPLPDNEK------------ 209

Human   165 GSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP----------CRGSARRSSR 219
                ::::|..||.|.:|.||.|...::.|.|.:|::...:||:|          .....:....
  Fly   210 ----QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEED 270

Human   220 EQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLL---- 280
            |.|   .....||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|.
  Fly   271 EVP---DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVA 332

Human   281 -------VPK----------NDDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 327
                   :||          |..:|.|.: .:|:.|||||||.||||:||:|||.|||:...|||
  Fly   333 EEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELG 397

Human   328 FLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSIC 392
            .|:|.|.:.:::|::.:::||.|:..:.|.|||.|||:.:|||||:|||||.|..:.|||.||:|
  Fly   398 LLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLC 462

Human   393 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 427
            :::|||.||||||||||||:..||:....::.::|
  Fly   463 AIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND1	NP_004970.3	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881	2..20
		BTB_POZ	6..143	CDD:453885	42/107 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..163		2/18 (11%)
		Ion_trans	185..417	CDD:459842	107/263 (41%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		8/12 (67%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		3/4 (75%)
		DUF3399	470..550	CDD:463381
		Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	49/146 (34%)
		Ion_trans	226..488	CDD:459842	108/264 (41%)