Protein Alignment KCND1 and CG43155

DIOPT Version :10

• Sequence 1: NP_004970.3
• Gene: KCND1 / 3750
• HGNCID: 6237
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 70/353 - (19%)
• Similarity: 124/353 - (35%)
• Gaps: 124/353 - (35%)

Human   133 LEEYRDRKK---ENAERLAEDEEAEQAGDGPALPAGSSLRQR--------LWRAFENPHTSTAAL 186
            ::||..:.:   |..|:|...:....|.:|..|..|::..:|        .|::..| |
  Fly     8 VKEYDSQDEASTELLEKLKHLDRRVDAAEGGGLAKGTAGGRRSTACWQSMKWKSALN-H------ 65

Human   187 VFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCG-ERFPQAFFCMDTACVLIFTGEYLLRL 250
                 .|..:::|:...|       |.......|:|.. ||...                  |:.
  Fly    66 -----IGLLVSLSIYCGV-------GGLIFRHLERPAEVERLSH------------------LKD 100

Human   251 FAAPSRCRFLRSVMSLIDV---VAILPYYI-------------GLLVPKNDDVSGAFVTLRVFRV 299
            .....|.|||.::::..:|   ..:|.:.:             |||:..:.|....:....:.:.
  Fly   101 IVKTHRERFLHTILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQA 165

Human   300 FRIFKFSRHSQGLRILGY-----------TLKSCASELGFLLFSLTM----------AIIIFATV 343
              :| ||  |..|..:||           ....|.:.:| :.|:||:          |:.:|...
  Fly   166 --VF-FS--STVLTTIGYGNIVPVTTGGRVFCICFALIG-IPFTLTVIADWGRLFATAVSVFGKH 224

Human   344 MFYAEKGTN---KTNFTSIPA--------------------------AFWYTIVTMTTLGYGDMV 379
            |....|.||   ||.|.:|.|                          .|::..:||||:|:||:|
  Fly   225 MPTKPKFTNFIGKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLV 289

Human   380 PSTIAGKIFGSICSLSGVLVIALPVPVI 407
            |..   ..:..:|:|..::.:||...:|
  Fly   290 PKK---PNYMLLCTLYILIGLALTSTII 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND1	NP_004970.3	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881	2..20
		BTB_POZ	6..143	CDD:453885	2/12 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..163		4/18 (22%)
		Ion_trans	185..417	CDD:459842	57/290 (20%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		3/23 (13%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		2/4 (50%)
		DUF3399	470..550	CDD:463381
		Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	16/76 (21%)
		Ion_trans_2	<267..319	CDD:462301	15/51 (29%)