DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCND1 and shl-1

DIOPT Version :10

Sequence 1:NP_004970.3 Gene:KCND1 / 3750 HGNCID:6237 Length:647 Species:Homo sapiens
Sequence 2:NP_500975.2 Gene:shl-1 / 177400 WormBaseID:WBGene00022240 Length:578 Species:Caenorhabditis elegans


Alignment Length:618 Identity:346/618 - (55%)
Similarity:434/618 - (70%) Gaps:75/618 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     3 AGLATWLPFARAAAVGWLPLAQQPLPPAP-GVKASR------GDEVLVVNVSGRRFETWKNTLDR 60
            |.:|.|||||||||:||:|:::||:|.|| .::|..      .||.|.:|:||||||||||||::
 Worm     2 ASVAAWLPFARAAAIGWVPISRQPMPQAPVAIQAKDLAVDHVSDEKLAINISGRRFETWKNTLEK 66

Human    61 YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVP 125
            :|:|||||:|||||||.|:||||||||||:|||:|.|||||:||.||.||:.|:||||:|:|::|
 Worm    67 FPETLLGSNEKEFFYDEDTGEYFFDRDPDIFRHILTFYRTGKLHYPRHECLVAYDEELSFFGIMP 131

Human   126 ELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYY 190
            :|:.|||.|:|:|:|:||.||| ::|..|.| |...|..  ||::::|.|||||||::.||||||
 Worm   132 DLISDCCYEDYKDKKRENQERL-QEERVENA-DISTLKL--SLKEKMWAAFENPHTTSIALVFYY 192

Human   191 VTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPS 255
            |.||||||||:.|:||||||   ....:....|||.:.:.||.:|||||:|||.||.|||.:||.
 Worm   193 VIGFFIAVSVMCNIVETIPC---GYEDNVSVTCGEAYEEQFFVIDTACVIIFTIEYFLRLISAPD 254

Human   256 RCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLK 320
            |.:|:||:||:|||:||:|||:.|::..|.||||.||||||||||||||||||||||||||||||
 Worm   255 RIKFMRSIMSVIDVIAIMPYYVSLVLTDNKDVSGLFVTLRVFRVFRIFKFSRHSQGLRILGYTLK 319

Human   321 SCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAG 385
            |||||||||:|||.||||||||:|:||||..:.|.|||||:||||||||:|||||||||||||.|
 Worm   320 SCASELGFLVFSLAMAIIIFATIMYYAEKKVDATRFTSIPSAFWYTIVTLTTLGYGDMVPSTIMG 384

Human   386 KIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYK 450
            ||.|.:|||||||||||||||||||||||||||||||||:||:|.||||||:.|:.:..|....|
 Worm   385 KIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKKARLARIRIVKNASGLALFNKK 449

Human   451 QNGGLEDSGSGEEQAL----------CVRNRSAFEQQHHHLLHCLEKTTCHEFTD-ELTFSEALG 504
            :        :.|.:.|          .:|:...||.||||||.||||.|..||.: |:.|.    
 Worm   450 R--------AHEARMLAFEQGHLSFDALRDEDIFEIQHHHLLQCLEKATEREFVESEVMFE---- 502

Human   505 AVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSRGSMQELDMLAGLRRSH 569
                |||.:...|.::...|           :.||:. ||.  ..|.....|:|||.        
 Worm   503 ----GGRNTPPPSETASLKG-----------KTKRKR-RLC--CVSKENEEMEELDR-------- 541

Human   570 APQSRSSLN---------AKPHDSLDLNCDSRD 593
              ::|.:.|         .|| |.::||..:.|
 Worm   542 --ETRVTFNQNMDQICELPKP-DEMELNHRNND 571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCND1NP_004970.3 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20 12/16 (75%)
BTB_POZ 6..143 CDD:453885 90/143 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..163 7/18 (39%)
Ion_trans 185..417 CDD:459842 172/231 (74%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 12/12 (100%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
DUF3399 470..550 CDD:463381 26/80 (33%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 12/14 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634
shl-1NP_500975.2 BTB_POZ 6..149 CDD:453885 89/142 (63%)
Ion_trans 187..416 CDD:459842 172/231 (74%)
DUF3399 472..>511 CDD:463381 20/46 (43%)
Blue background indicates that the domain is not in the aligned region.

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