Protein Alignment KCND1 and shl-1

DIOPT Version :9

• Sequence 1: XP_024308146.1
• Gene: KCND1 / 3750
• HGNCID: 6237
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_500975.2
• Gene: shl-1 / 177400
• WormBaseID: WBGene00022240
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 641
• Identity: 350/641 - (54%)
• Similarity: 439/641 - (68%)
• Gaps: 93/641 - (14%)

Human     3 AGLATWLPFARAAAVGWLPLAQQPLPPAP-GVKASR------GDEVLVVNVSGRRFETWKNTLDR 60
            |.:|.|||||||||:||:|:::||:|.|| .::|..      .||.|.:|:||||||||||||::
 Worm     2 ASVAAWLPFARAAAIGWVPISRQPMPQAPVAIQAKDLAVDHVSDEKLAINISGRRFETWKNTLEK 66

Human    61 YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVP 125
            :|:|||||:|||||||.|:||||||||||:|||:|.|||||:||.||.||:.|:||||:|:|::|
 Worm    67 FPETLLGSNEKEFFYDEDTGEYFFDRDPDIFRHILTFYRTGKLHYPRHECLVAYDEELSFFGIMP 131

Human   126 ELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYY 190
            :|:.|||.|:|:|:|:||.||| ::|..|.| |...|..  ||::::|.|||||||::.||||||
 Worm   132 DLISDCCYEDYKDKKRENQERL-QEERVENA-DISTLKL--SLKEKMWAAFENPHTTSIALVFYY 192

Human   191 VTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPS 255
            |.||||||||:.|:||||||   ....:....|||.:.:.||.:|||||:|||.||.|||.:||.
 Worm   193 VIGFFIAVSVMCNIVETIPC---GYEDNVSVTCGEAYEEQFFVIDTACVIIFTIEYFLRLISAPD 254

Human   256 RCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLK 320
            |.:|:||:||:|||:||:|||:.|::..|.||||.||||||||||||||||||||||||||||||
 Worm   255 RIKFMRSIMSVIDVIAIMPYYVSLVLTDNKDVSGLFVTLRVFRVFRIFKFSRHSQGLRILGYTLK 319

Human   321 SCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAG 385
            |||||||||:|||.||||||||:|:||||..:.|.|||||:||||||||:|||||||||||||.|
 Worm   320 SCASELGFLVFSLAMAIIIFATIMYYAEKKVDATRFTSIPSAFWYTIVTLTTLGYGDMVPSTIMG 384

Human   386 KIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYK 450
            ||.|.:|||||||||||||||||||||||||||||||||:||:|.||||||:.|:.:..|....|
 Worm   385 KIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKKARLARIRIVKNASGLALFNKK 449

Human   451 QNGGLEVGRGLDRVGVSHNG-----EEGAALIALLHLLQDSGSGEEQALCVRNRSAFEQQHHHLL 510
            :               :|..     |:|       ||..|:         :|:...||.||||||
 Worm   450 R---------------AHEARMLAFEQG-------HLSFDA---------LRDEDIFEIQHHHLL 483

Human   511 HCLEKTTCHEFTD-ELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRRAIRLAN 574
            .||||.|..||.: |:.|.        |||.:...|.::...|           :.||:. ||.
 Worm   484 QCLEKATEREFVESEVMFE--------GGRNTPPPSETASLKG-----------KTKRKR-RLC- 527

Human   575 STASVSRGSMQELDMLAGLRRSHAPQSRSSLN---------AKPHDSLDLNCDSRD 621
             ..|.....|:|||.          ::|.:.|         .|| |.::||..:.|
 Worm   528 -CVSKENEEMEELDR----------ETRVTFNQNMDQICELPKP-DEMELNHRNND 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND1	XP_024308146.1	Shal-type	3..28	CDD:288455	16/24 (67%)
		BTB_2	42..131	CDD:308049	62/88 (70%)
		Ion_trans	185..417	CDD:306908	172/231 (74%)
		DUF3399	447..578	CDD:314709	34/136 (25%)
shl-1	NP_500975.2	BTB_POZ	6..149	CDD:365784	89/142 (63%)
		Ion_trans	187..416	CDD:366146	172/231 (74%)
		DUF3399	460..528	CDD:371777	32/105 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	363	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	672	1.000	Inparanoid score	I421
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48930
OrthoDB	1	1.010	-	-		D221939at33208
OrthoFinder	1	1.000	-	-		FOG0001867
OrthoInspector	1	1.000	-	-		otm14911
orthoMCL	1	0.900	-	-		OOG6_103639
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840