Protein Alignment ppk9 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_611622.2
• Gene: ppk9 / 37498
• FlyBaseID: FBgn0085398
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 84/461 - (18%)
• Similarity: 144/461 - (31%)
• Gaps: 201/461 - (43%)

  Fly   198 WHRFQTSPMVISMDRNKLVWNTSFPSLTVCPHKRIDELKVEEYILAHPDQFLSEEDQEDFRDFIV 262
            |:..|.:.:...:.:.:|| ..|:|.              |:.|||    .|...:..::|:|
Human   237 WYILQATNIFAQVPQQELV-EMSYPG--------------EQMILA----CLFGAEPCNYRNF-- 280

  Fly   263 KLASLTYDNL------------ETLPLNKSYGIPSTKY-LELLYEL-KWAFEPEISSGAAVKMFI 313
              .|:.|.:.            :.||...    |.|:: |:|:.:: :..:.|.::|.|.|::.:
Human   281 --TSIFYPHYGNCYIFNWGMTEKALPSAN----PGTEFGLKLILDIGQEDYVPFLASTAGVRLML 339

  Fly   314 YE-----------------TQTEFGICHSVNSMVARYNSFDYWRSGDWSLMDHGDRVTVHPLDGE 361
            :|                 |:|..|:                       |:|...|:      ||
Human   340 HEQRSYPFIRDEGIYAMSGTETSIGV-----------------------LVDKLQRM------GE 375

  Fly   362 IYAQ-IINLSTAYDVYFHGAGDVPSISKQRYTFPESDYTTVELIALEIFTNEEARATKQRSCRFN 425
            .|:. .:|           ..:||   .|.:   .|||.|.
Human   376 PYSPCTVN-----------GSEVP---VQNF---YSDYNTT------------------------ 399

  Fly   426 YEAEEMMTVPIYSFGLCLSECRMFFALRVCGCVPHFYRNRCGYNHIFGTQMRNGRRLPVCGLEGI 490
                       ||...||..|.....:|.|.|..:.|....|..:.      |.|..|    :..
Human   400 -----------YSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYC------NNRDFP----DWA 443

  Fly   491 GCLVKIKREIISLKSDKYKINC--NCLANCDDSNFFVQSYRSRV----WFLGANLQWGILEHPKM 549
            .|...::..:...::      |  .|..:|:|:     .|:..:    |...|:..|  :.|...
Human   444 HCYSDLQMSVAQRET------CIGMCKESCNDT-----QYKMTISMADWPSEASEDW--IFHVLS 495

  Fly   550 QLR-------------------------REVLFSFADVLVY----IGGLVGFFLGCSAL---SFT 582
            |.|                         |.:..|.|:.:|:    :||..||::|.|.|   .|.
Human   496 QERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFG 560

  Fly   583 EIIYYF 588
            |||..|
Human   561 EIIIDF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:459966	83/458 (18%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	84/461 (18%)