Protein Alignment ppk9 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_611622.2
• Gene: ppk9 / 37498
• FlyBaseID: FBgn0085398
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 111/619 - (17%)
• Similarity: 192/619 - (31%)
• Gaps: 201/619 - (32%)

  Fly    37 DSLLTSSTASLLP----PQDNNRRLGPGPGLLIFPGTGQRHQHNPNGSTGSKTIAKANDGNAAIN 97
            |.....||..|:.    .:.:.|.|.|.|||:......::....|..:.|   :.|.|.......
Human    29 DPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPG---LMKGNKREEQGL 90

  Fly    98 QPGPARSIRSFRRPPLWQPPPQDHAQDGQEMEVLDRQKRKDCRPACLVKGQAFIIEFL-QGSSIH 161
            .|.||              .||....:.:.:....|..|:             :.||. ..::||
Human    91 GPEPA--------------APQQPTAEEEALIEFHRSYRE-------------LFEFFCNNTTIH 128

  Fly   162 GFIYLA-----KLGLSFVERVLWLAFICV--ALFSIISLSKRTWHRFQTSPMVISMDRNKLVWNT 219
            |.|.|.     ::..:| ..||||   |.  .::....|....:..:..| :.|:::.:|||
Human   129 GAIRLVCSQHNRMKTAF-WAVLWL---CTFGMMYWQFGLLFGEYFSYPVS-LNINLNSDKLV--- 185

  Fly   220 SFPSLTVC---PHKRIDELKVE----------------EY------------------ILAHPDQ 247
             ||::|:|   |: |..|:|.|                :|                  .|.||.|
Human   186 -FPAVTICTLNPY-RYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQ 248

  Fly   248 FL--------------------SEEDQEDFRDFIVKLASLTYDNLETLPLNKSYGIPSTK----- 287
            .|                    ....|.|::|:.:.......:..:......|.|:.:.:
Human   249 RLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF 313

  Fly   288 -YLELLYELKWAFEPEISSGA---AVKMFIYETQTE----------------FGICHSVNSMVAR 332
             |:.:|..|     ||.....   .:..||:..:..                :|.|::.|..
Human   314 HYINILSRL-----PETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDK--- 370

  Fly   333 YNSFDYWRS------GDWSLMDHGDRVTVHPLDGEIYAQIINLSTAYDVYFHGAGDVPSISKQRY 391
             |:.:.|.|      ...|||...::....||        ::..|...|..||..:...:....:
Human   371 -NNSNLWMSSMPGINNGLSLMLRAEQNDFIPL--------LSTVTGARVMVHGQDEPAFMDDGGF 426

  Fly   392 TFPESDYTTVEL--IALEIFTNEEARATKQRSCRFNYEAEEMMTVPI-------YSFGLCLSECR 447
            .......|::.:  ..|:....:....||..|           .||:       |:..:|:..|.
Human   427 NLRPGVETSISMRKETLDRLGGDYGDCTKNGS-----------DVPVENLYPSKYTQQVCIHSCF 480

  Fly   448 MFFALRVCGCVPHFYR-----NRCGYNHIFGTQMRNGRRLPVCGLEGIGCLVKIKREIISLKSDK 507
            ....::.|||...||.     ..|.|           |:....|.    |..|::   :...||.
Human   481 QESMIKECGCAYIFYPRPQNVEYCDY-----------RKHSSWGY----CYYKLQ---VDFSSDH 527

  Fly   508 YKINCNCLANCDDSNFFVQSYRSRVWFLGANLQW 541
            ......|...|..:::.:.:..|| |....:.:|
Human   528 LGCFTKCRKPCSVTSYQLSAGYSR-WPSVTSQEW 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:459966	89/498 (18%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	91/518 (18%)