Protein Alignment ppk9 and Asic5

DIOPT Version :10

• Sequence 1: NP_611622.2
• Gene: ppk9 / 37498
• FlyBaseID: FBgn0085398
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_067345.1
• Gene: Asic5 / 58170
• MGIID: 1929259
• Length: 495
• Species: Mus musculus
• Alignment Length: 555
• Identity: 113/555 - (20%)
• Similarity: 192/555 - (34%)
• Gaps: 160/555 - (28%)

  Fly   119 QDHAQDGQEMEVLDRQKR---KDCRPACLVKGQAFIIEFLQGSSIHGFIYLAKLGLSFVERVLWL 180
            |.||:.|    :|.:.||   |...|:...: :.|..:|...:|.||...:|: ..:.|.:|:||
Mouse     8 QVHAEKG----LLGKIKRYLSKRPLPSPTDR-KKFDQDFAMSTSFHGIHNIAQ-NQNKVRKVIWL 66

  Fly   181 AFICVALFSIISLSKRTWHRFQTSPMVISMDRNKLVWNTS------------FPSLTVCPHKRID 233
            |.:      :.|:|...|..:  |.:|     |...|.|:            ||::|:|...|..
Mouse    67 AVV------LGSVSLLVWQIY--SRLV-----NYFTWPTTTSIEVQYVEKIEFPAVTLCNLNRFQ 118

  Fly   234 ELKVEEY------------ILAHPDQFLSEEDQEDFRDFIVKLASLT----------YDNLETLP 276
            ...|..:            :|...:...:.....:..||:....:.:          |.|.:||.
Mouse   119 TEAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETLDFVTNHQNFSITEFVKNNGFYLNNDTLV 183

  Fly   277 LNKSYG-IPSTKYLELLYELKWAFEPEISSGAAVKMFIYETQTEFGICHSVN--SMVARYNSFDY 338
            ..:.:| ..|.|      :.|..|                  ||:|.|.:.|  ..:...|....
Mouse   184 HCEFFGKTCSPK------DFKHVF------------------TEYGNCFTFNYGENIQNKNKVSV 224

  Fly   339 WRSGDWSLMD-HGDRVTVHPLDGEIYAQIINL--STAYDVYFHGAGDVPSISKQRYTFPESDYTT 400
            ...|...|:| |.:..|.:|:.|...|.:|.:  |...:..|.|.|         .:.|...:..
Mouse   225 SGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLG---------LSSPVGMHAR 280

  Fly   401 VELIALEIFTNEEARATKQRSCRFNYEAEEMMTVPIYSFGLCLSECRMFFALRVCGCVPHFYRNR 465
            |.:..|:....|....    .|..|.:....:|...|.   ||.||:.....|:|||:|..
Mouse   281 VTIRQLKTVHQEYPWG----ECNPNIKLRNFITYSTYG---CLKECKARHIQRLCGCLPFL---- 334

  Fly   466 CGYNHIFGTQMRNGRRLPVCG-----LEGIGCLVKI-----KREIISLKSDKYKINCNCLANCDD 520
                            ||..|     ||...|:..|     ::.:.::.:.    |.:|..:|::
Mouse   335 ----------------LPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTH----NSSCPVSCEE 379

  Fly   521 -----------------SNFFVQSYRSRVWFLGANL-----QWGILEHPKMQLRREVLFSFADVL 563
                             :.|..:.......::..||     .:..|.:...|.::.|  |..::|
Mouse   380 TEYPATVSYSTFPSQRATRFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAV--SVPELL 442

  Fly   564 VYIGGLVGFFLGCSALSFTEIIYYFTARFVRRMFF 598
            ..:||.:|.|.|.|.::..|||.||...|...:.|
Mouse   443 ADVGGQLGLFCGASLITIIEIIEYFFTNFYWVLIF 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:459966	99/504 (20%)
Asic5	NP_067345.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30		8/25 (32%)
		ASC	41..466	CDD:459966	99/504 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)