DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk9 and asic1b

DIOPT Version :9

Sequence 1:	NP_611622.2	Gene:	ppk9 / 37498	FlyBaseID:	FBgn0085398	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	588	Identity:	97/588 - (16%)
Similarity:	187/588 - (31%)	Gaps:	189/588 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 STGSKTIAKANDGNAAINQPGPARSIRSFRRPPLWQPPPQD--HAQDGQEMEVLDRQKRKDCRPA 142
            ||..:.:.::..|           |.....:..:|....:.  :.::|.:.:..|..:.::....
Zfish    11 STDDEPVGRSRQG-----------SFDDHYKRVVWSKDGEQGKYQEEGDDPDAYDGPEDEEAPDI 64

  Fly   143 CLVKGQAFIIEFLQGSSIHG----FIYLAKLGLSFVERVLW-LAFICVALFSIISLSKRTWHRFQ 202
            .|.       .|..|.|:||    |:...|..   :.:.|| |.|:......::.:..|..:..|
Zfish    65 SLA-------TFFGGCSLHGANHVFVEDKKFS---IRQGLWALVFLLAISMFLLQVVDRVIYYLQ 119

  Fly   203 TSPMVISMDRNKLVWNTSFPSLTVCPHK--RIDELKVEEY-----ILAHPDQ------FLSEEDQ 254
            ...:.:..:||  ..|.:||::|:|.:.  |..:|...:.     :|.:.|.      ...|.|:
Zfish   120 YDYVTLLDERN--AKNMTFPAITLCNYNTFRRSQLSYSDLLFMGPLLGYEDNMAPGIPLAPEPDR 182

  Fly   255 EDFRDFIVKLASLTYDNLETLPLNKSYGIPSTKYLELLYELKWAFEPEISSGAAVKMFIYETQTE 319
            :..|..:.:..:.|...::                ::|.|..:|.:   ..||.....|:   |.
Zfish   183 QGSRFSLAEFFNRTRHRMD----------------DMLLECNFAGK---ECGAEHWREIF---TR 225

  Fly   320 FGICHSVNS--------------------MVARYNSFDY---WRSGDWSLMDHGDRVTVHPLDGE 361
            :|.|::.||                    ::......:|   |...|.:..:.|.:|.:|..|..
Zfish   226 YGKCYTFNSGQDGRPLLITTKGGMGNGLEIMLDIQQDEYLPVWGETDETTFEAGIKVQIHTQDEP 290

  Fly   362 IYAQIINLSTAYDVYFHGAGDVPSISKQRYTF---PESDYTTVELIALEIFTNEEARATKQRSCR 423
            .:...:....|     .|.....|..:||.|:   |..|                .:||...|..
Zfish   291 PFIDQLGFGVA-----PGFQTFVSCQEQRLTYLPPPWGD----------------CKATPIDSDF 334

  Fly   424 FNYEAEEMMTVPIYSFGLCLSECRMFFALRVCG------------CVPHFYRNRCGYNHIFGTQM 476
            ||          .||...|..:|...:.:..|.            |.|..|:.
Zfish   335 FN----------TYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKE------------ 377

  Fly   477 RNGRRLPVCGLEGIGCLVKIKREIISLKSDKYKINCNCLANCD-----------------DSNFF 524
                    |....:..||:        :.:.|   |.|...|:                 .:.:.
Zfish   378 --------CADPALDFLVE--------RDNDY---CVCETPCNMTRYGKELSFVRIPSKASAKYL 423

  Fly   525 VQSYRSRVWFLGANLQ-----WGILEHPKMQLRREVLFSFADVLVYIGGLVGFFLGCSALSFTEI 584
            .:.|.....::..|:.     :..|.:..::.::  .:..|.:|..|||.:|.|:|.|.|:..|:
Zfish   424 AKKYNKTEQYISDNIMVLDIFFEALNYETIEQKK--AYELAGLLGDIGGQMGLFIGASILTILEL 486

  Fly   585 IYY 587
            ..|
Zfish   487 FDY 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:279230	88/510 (17%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57		2/20 (10%)
		ASC	66..548	CDD:295594	90/522 (17%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950