DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk9 and asic4a

DIOPT Version :9

Sequence 1:	NP_611622.2	Gene:	ppk9 / 37498	FlyBaseID:	FBgn0085398	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	534	Identity:	105/534 - (19%)
Similarity:	187/534 - (35%)	Gaps:	166/534 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 QDGQEMEVLDRQKRKDCRPACLVKGQAFIIEFLQGSSIHGFIYLAKLGLSFVERVLW-LAFICVA 186
            |||.:..:::    :.|.|.  .|..|   .|...||:||..::...|...|.:.|| |||: |:
Zfish    22 QDGDKESLIE----ESCSPP--TKDLA---GFASASSLHGINHIFVSGRLGVRQTLWALAFL-VS 76

  Fly   187 LFSIISLSKRTWHRFQTSPMVISMDRN---KLVWNTSFPSLTVCPHKRIDELKVEEYILAHPDQF 248
            |...:..:.:....:...|.|.:::..   ::|    ||::|:|...|.              :|
Zfish    77 LALFLYQAAKCAISYLEHPHVTALNEEATPEMV----FPAVTICNINRF--------------RF 123

  Fly   249 LSEEDQEDFRDFIVKLASLTYDNLETLPLNK--------SYGIPSTKYL---------ELLYELK 296
            .:..|.:     |..||:||    ...|.||        .|..|..:.:         |:|....
Zfish   124 SALTDAD-----IYHLANLT----GLPPKNKDGHKPTDLEYPAPDMQDIFNRTGHQLEEMLKSCN 179

  Fly   297 WAFEPEISSGAAVKMFIYETQTEFGICHSVN------------------SMVARYNSFDY---WR 340
            ::.:   :..|.....:|   |.:|.|::.|                  .::......||   |:
Zfish   180 FSGQ---NCSAEDFTVVY---TRYGKCYTFNGNKTTSRKTKQGGMGNGLEIMLDIQQDDYLPIWK 238

  Fly   341 SGDWSLMDHGDRVTVHPLDGEIYAQII--NLSTAYDVYFHGAGDVPSISKQRYTFPESDYTTVEL 403
            ..:.:.::.|.||.:|..|...|...:  .:|..:..:.       |..:||.|:....:
Zfish   239 ETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFV-------SCQEQRLTYLPQPW----- 291

  Fly   404 IALEIFTNEEARATKQRSCRFNYEAEEMMTVP---IYSFGLCLSECRMFFALRVCGCVPHFYRNR 465
                            .:||..  :|:|  :|   .||...|...|.....||.|         :
Zfish   292 ----------------GNCRST--SEQM--IPGYDTYSISACRLRCETLEVLREC---------K 327

  Fly   466 CGYNHIFGTQMRNGRRLPVCGLEGIGCLVKIKREIISLKSDKYKINCNCLANCDDSNFFVQ---- 526
            |...|:.|.       ..:|....|.|:.|    .::|........|.|...|:.:.:..:
Zfish   328 CRMVHMPGD-------ANICTPSDIKCVDK----ALALLQKSSGDTCFCETPCNLTRYGKELSMV 381

  Fly   527 --------SYRSRVW----------FLGANLQWGILEHPKMQLRREVLFSFADVLVYIGGLVGFF 573
                    .|.||.:          ||..::.:..|.:..::.::  .:..|.:|..|||.:|.|
Zfish   382 KIPSKGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKK--AYDVAGLLGDIGGQMGLF 444

  Fly   574 LGCSALSFTEIIYY 587
            :|.|.|:..||:.|
Zfish   445 IGASVLTILEILDY 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:279230	97/501 (19%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	98/503 (19%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850