Protein Alignment ppk9 and Scnn1g

DIOPT Version :10

• Sequence 1: NP_611622.2
• Gene: ppk9 / 37498
• FlyBaseID: FBgn0085398
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_058742.2
• Gene: Scnn1g / 24768
• RGDID: 3641
• Length: 650
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 105/560 - (18%)
• Similarity: 183/560 - (32%)
• Gaps: 193/560 - (34%)

  Fly   174 VERVLWLAFICVALFSIISLSKRTWHRFQTSPMVISMDRNKLVWNTSFPSLTVCPHKRIDELKVE 238
            :.|:||:||...|:..||.........|.|..:.|.:...||    .||::|:|        .:.
  Rat    51 LRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKL----DFPAVTIC--------NIN 103

  Fly   239 EYILAHPDQFLSEEDQEDFRDFIVKLASLT-YDNLETLPLNKSYGIPST------KYLELLYEL- 295
            .|..:.....|::.|.|      .|.|.|: |...|:....::..:|||      ::.:|:..|
  Rat   104 PYKYSAVSDLLTDLDSE------TKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLV 162

  Fly   296 ----------------KWAFEPEISSGAAVKMFIYETQ--TEFGICHSVNSMVARY------NSF 336
                            |.....:|...|:..|.::|::  ..|.:|.:..|..|.|      |:.
  Rat   163 FNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAI 227

  Fly   337 DYWRSGDWSL----------------MDHGDR---VTV----------------HPLDGEIY--- 363
            ..|    :.|                |.:..:   ||.                ||:.|..|
  Rat   228 QEW----YKLHYMNIMAQVPLEKKINMSYSAKELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFN 288

  Fly   364 ----AQIINLSTAYDVYFHGAGDVPSISKQRYT-------------FPESDYTTVELIALEIFTN 411
                |.|::.|.....|  |...:..|::..|.             ..:::|..:|.:.:||
  Rat   289 NKENATILSTSMGGSEY--GLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGMEI--- 348

  Fly   412 EEARATK---------QRSCRFNYEAEEMMTVPI-------YSFGLCLSECRMFFALRVCGCVPH 460
            |.|.:|.         :.|..::...|:...||:       ||..:||..|.....:..|||..:
  Rat   349 ETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQY 413

  Fly   461 FY-----RNRCGY----NHIFGTQMRNGRRLPVCGLEGIGCLVKIKREIISLKSDKYKINCN--C 514
            ..     .|.|.|    |.::                   |..::.:..:     :.::.|.  |
  Rat   414 SQPLPPAANYCNYQQHPNWMY-------------------CYYQLYQAFV-----REELGCQSVC 454

  Fly   515 LANCDDSNFFV-------QSYRSRVWFLGANLQWGILEHPKMQLRR----EVLFSFAD------- 561
            ..:|....:.:       .|..|..|.|.. |.|...:....:|.:    ::|..:.|
  Rat   455 KQSCSFKEWTLTTSLAQWPSEASEKWLLNV-LTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIM 518

  Fly   562 ---------VLVYIGGLVGFFLGCSALSFTEIIYYFTARF 592
                     :|...||.:|.::.||.:...|||..|...|
  Rat   519 ESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDF 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:459966	103/553 (19%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	105/560 (19%)
		Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000250|UniProtKB:P51170	135..222		15/86 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..628
		PY motif, mediates interaction, ubiquitination and inhibition by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927	624..628
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170	624..628