DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk9 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_611622.2	Gene:	ppk9 / 37498	FlyBaseID:	FBgn0085398	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_035456.1	Gene:	Scnn1g / 20278	MGIID:	104695	Length:	655	Species:	Mus musculus

Alignment Length:	562	Identity:	103/562 - (18%)
Similarity:	180/562 - (32%)	Gaps:	192/562 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 VERVLWLAFICVALFSIISLSKRTWHRFQTSPMVISMDRNKLVWNTSFPSLTVCPHKRIDELKVE 238
            :.|:||:||...|:..||.........|.|..:.|.:...||    .||::|:|        .:.
Mouse    51 LRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKL----DFPAVTIC--------NIN 103

  Fly   239 EYILAHPDQFLSEEDQEDFRDFIVKLASLTY----DNLETLPLNKS---------YGIPSTKYLE 290
            .|..:.....|::.|.|      .|.|.|:.    |.|::.|..:.         .|.| .::|.
Mouse   104 PYKYSAVSDLLTDLDSE------TKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTP-PRFLN 161

  Fly   291 LLYEL-----------------KWAFEPEISSGAAVKMFIYETQ--TEFGICHSVNSMVARY--- 333
            |:..|                 |.....:|...|:..|.::|::  ..|.:|.:..|..|.|
Mouse   162 LIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFS 226

  Fly   334 ---NSFDYWRSGDW-------------SLMDHGDRVTV------------------HPLDGEIY- 363
               |:...|....:             ::....:.:.|                  ||:.|..|
Mouse   227 SGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYT 291

  Fly   364 ------AQIINLSTAYDVYFHGAGDVPSISKQRY-------------TFPESDYTTVELIALEIF 409
                  |.|::.|.....|  |...:..|::..|             ...:::|..:|.:..||
Mouse   292 FNNRENATILSTSMGGSEY--GLQVILYINEDEYNPFLVSSTGAKVLVHQQNEYPFIEDVGTEI- 353

  Fly   410 TNEEARATK---------QRSCRFNYEAEEMMTVPI-------YSFGLCLSECRMFFALRVCGCV 458
              |.|.:|.         :.|..::...|:...||:       ||..:||..|.....:..|||.
Mouse   354 --ETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCA 416

  Fly   459 PHFY-----RNRCGY----NHIFGTQMRNGRRLPVCGLEGIGCLVKIKREIISLKSDKYKINCN- 513
            .:..     .|.|.|    |.::                   |..::.:..:     :.::.|.
Mouse   417 QYSQPLPPAANYCNYQQHPNWMY-------------------CYYQLYQAFV-----REELGCQS 457

  Fly   514 -CLANCDDSNFFV-------QSYRSRVWFLGANLQWGILEHPKMQLRR----EVLFSFAD----- 561
             |..:|....:.:       .|..|..|.|.. |.|...:....:|.:    ::|..:.|
Mouse   458 VCKQSCSFKEWTLTTSLAQWPSEASEKWLLNV-LTWDQSQQINKKLNKTDLAKLLIFYKDLNQRS 521

  Fly   562 -----------VLVYIGGLVGFFLGCSALSFTEIIYYFTARF 592
                       :|...||.:|.::.||.:...|||..|...|
Mouse   522 IMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDF 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:279230	101/555 (18%)
Scnn1g	NP_035456.1	ENaC	24..636	CDD:273304	103/562 (18%)
		deg-1	32..557	CDD:273309	100/554 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750