DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk9 and Asic1

DIOPT Version :9

Sequence 1:	NP_611622.2	Gene:	ppk9 / 37498	FlyBaseID:	FBgn0085398	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001276720.1	Gene:	Asic1 / 11419	MGIID:	1194915	Length:	559	Species:	Mus musculus

Alignment Length:	543	Identity:	99/543 - (18%)
Similarity:	184/543 - (33%)	Gaps:	147/543 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LWQPPPQDHAQDGQEMEVLDRQKRKDCRPAC-LVKGQA--FIIEFLQGSSIHGFIYLAKLGLSFV 174
            :|  .|..|.:..|:....:.::.|:..... |.:|.:  .::.|....::||..::      ||
Mouse    24 IW--GPHHHHRQQQDSSESEEEEEKEKESGMELDEGDSPRDLVAFANSCTLHGASHV------FV 80

  Fly   175 E------RVLWLAFICVALFSII-SLSKRTWHRFQTSPMVISMDR---NKLVWNTSFPSLTVCPH 229
            |      :.||.....:||.:.: .:..|..: :.:.|.|..:|.   .:||    ||::|.|..
Mouse    81 EGGPGPRQALWAVAFVIALGAFLCQVGDRVAY-YLSYPHVTLLDEVATTELV----FPAVTFCNT 140

  Fly   230 K--RIDELKVEEYILAHPDQFLSEEDQEDFRDFIVKLASLTYDNLETLPLN--KSYGIPSTKYLE 290
            .  |:.:|...:.:...|...|.|.|     |..|.||....:.....|.|  :.|.....:..:
Mouse   141 NAVRLSQLSYPDLLYLAPMLGLDESD-----DPGVPLAPPGPEAFSGEPFNLHRFYNRSCHRLED 200

  Fly   291 LLYELKWAFEPEISSGAAVKMFIYETQTEFGICHSVNS--------------------MVARYNS 335
            :|....:...|......:|..      |.:|.|::.||                    ::.....
Mouse   201 MLLYCSYCGGPCGPHNFSVVF------TRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQ 259

  Fly   336 FDY---WRSGDWSLMDHGDRVTVHPLDGEIYAQIINLSTAYDVYFHGAGDVPSISKQRYTFPESD 397
            .:|   |...|.:..:.|.:|.:|..|...:...:....|     .|.....|..:||..:..|.
Mouse   260 DEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVA-----PGFQTFVSCQEQRLIYLPSP 319

  Fly   398 YTTVELIAL--EIFTNEEARATKQRSCRFNYEAEEMMTVPIYSFGLCLSECRMFFALRVCG---- 456
            :.|...:.:  :.|.:....|     ||.:.|..       |....|  .|||   :.:.|
Mouse   320 WGTCNAVTMDSDFFDSYSITA-----CRIDCETR-------YLVENC--NCRM---VHMPGDAPY 367

  Fly   457 CVPHFYRNRCGYNHIFGTQMRNGRRLPVCGLEGIGCLVKIKREIISLKSDKYKINCNCLANCD-- 519
            |.|..|:.                    |....:..||:        |..:|   |.|...|:
Mouse   368 CTPEQYKE--------------------CADPALDFLVE--------KDQEY---CVCEMPCNLT 401

  Fly   520 ---------------DSNFFVQSYRSRVWFLGANLQ-----WGILEHPKMQLRREVLFSFADVLV 564
                           .:.:..:.:.....::|.|:.     :.:|.:..::.::  .:..|.:|.
Mouse   402 RYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKK--AYEIAGLLG 464

  Fly   565 YIGGLVGFFLGCSALSFTEIIYY 587
            .|||.:|.|:|.|.|:..|:..|
Mouse   465 DIGGQMGLFIGASILTVLELFDY 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk9	NP_611622.2	ASC	154..587	CDD:279230	91/497 (18%)
Asic1	NP_001276720.1	ASC	63..541	CDD:295594	92/502 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842209
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850