DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpN58A and PPP3CC

DIOPT Version :9

Sequence 1:	NP_477384.1	Gene:	PpN58A / 37493	FlyBaseID:	FBgn0025573	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001230903.1	Gene:	PPP3CC / 5533	HGNCID:	9316	Length:	521	Species:	Homo sapiens

Alignment Length:	314	Identity:	114/314 - (36%)
Similarity:	171/314 - (54%)	Gaps:	44/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKLLSNGSNKNKTLK---FDEGINLDQIIAKLKLIGEIGSVVQISVREIEAVCSRAREVLLKQPT 64
            |::..||..|...||   ..|| .|::.:| ||:|.:                  ...:|.::.|
Human    29 KEVFENGKPKVDVLKNHLVKEG-RLEEEVA-LKIIND------------------GAAILRQEKT 73

  Fly    65 LLEIPAPINLLGDIHGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPT 129
            ::|:.|||.:.||||||:.:|::.||..|.|.::.||.||||||||..|||.:..|.:||..:|.
Human    74 MIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPK 138

  Fly   130 KFYLLRGNHECSSINHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLF 194
            ..:||||||||..:..::.|..||:.:|:.:::...::.::||||||::.:...|.|||:||.:.
Human   139 TLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEIT 203

  Fly   195 SMQQIREIRRPIEIPESGLICDILWSDPDLRIMGWGPNE-----------RGVSHTFGSDVVSAF 248
            |:..||::.|..|.|..|.:||:|||||.   ..:| ||           ||.|:.:....|..|
Human   204 SLDDIRKLDRFTEPPAFGPVCDLLWSDPS---EDYG-NEKTLEHYTHNTVRGCSYFYSYPAVCEF 264

  Fly   249 LHRFKLNLICRGHQVVEDGYEFFAKRQ------LITIFSAPNYCGEFDNAGAMM 296
            |....|..|.|.|:..:.||..:.|.|      ||||||||||...::|..|::
Human   265 LQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpN58A	NP_477384.1	PTZ00480	22..311	CDD:185658	106/292 (36%)
PpN58A	NP_477384.1	MPP_superfamily	23..311	CDD:301300	106/291 (36%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	111/306 (36%)
		Catalytic. /evidence=ECO:0000305	52..343		106/290 (37%)
		PP2Ac	54..325	CDD:197547	105/288 (36%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	395..409
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	410..417
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	468..490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820