DRSC/TRiP Functional Genomics Resources

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Protein Alignment PpN58A and PPP3CA

DIOPT Version :10

Sequence 1:NP_477384.1 Gene:PpN58A / 37493 FlyBaseID:FBgn0025573 Length:324 Species:Drosophila melanogaster
Sequence 2:NP_000935.1 Gene:PPP3CA / 5530 HGNCID:9314 Length:521 Species:Homo sapiens


Alignment Length:1316 Identity:239/1316 - (18%)
Similarity:403/1316 - (30%) Gaps:490/1316 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   322 SLGGNSKTIMIAAISPADVNYSE------TLSTLRYANRAKNIINKPTIN--EDPNVKL-IRELR 377
            |...::|:.:....|.:::||.:      ..:||....|:.::.:.|..|  |.|:.|: .|:.|
Human   706 SFSEDTKSPLSVPRSKSEMNYIDGEKVVKRSATLPLPARSSSLKSSPERNDWEPPDKKVDTRKYR 770

  Fly   378 DE---IYKLKLMLSSDSGAELEPQLKVLEDLHKKEAQEKVLTEEWTEKWREAQ------------ 427
            .|   ||:.:...||....|     |:..|:..:|...|  .|.|.:.:.|.:            
Human   771 AEPKSIYEYQPGKSSVLTNE-----KMSRDISPEEIDLK--NEPWYKFFSELEFGRPPPKKIWDY 828

  Fly   428 -----SIL-REQRSLGLRKSGVGVVLDSEVPHLIGIHDDISTGVTLYSLKEGETTIGTDEAPYPQ 486
                 ||| |..|...|.|.......:.|.                 .|::.||...:..|..||
Human   829 TPGDCSILPRGDRKTNLEKDLNLCQAELEA-----------------DLEKVETVNKSPTAHVPQ 876

  Fly   487 DISLNGIGIAPEHCRIVLSNGNATIYPNPNATCLLNASIIEVPTAISQGDILLLGRTNMFRYNNP 551
                                 ::.:.|.|:.|.       |.|..|...|...:.|.:   ...|
Human   877 ---------------------SSAVSPTPDITS-------EPPGYIYSSDFHAVKRES---DGTP 910

  Fly   552 AEAAKMRQESSHQQRASRL---DLSRLSLIAASRENLCASFMSDDDGG----VSGSSLSLFGGGG 609
            ...|.:  |:..|...|.|   |:....|....|.:..||...|..||    :|.||:       
Human   911 GGLASL--ENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSV------- 966

  Fly   610 GGAGGMASPQGAFRFRQYTPSREDAELQDEHRKILQTIENALRQLNLERTRMHEQFKHK-----I 669
                                          |.:...| .|||          ....|||     .
Human   967 ------------------------------HSRTFHT-SNAL----------GPGCKHKKPLSAA 990

  Fly   670 RLCTEELERLESTKRDRLTVLDCRIGELMARKEMVLWEKSNEKTQVDILVRQLSALQTQLDTKKR 734
            :.|..|:  |.|..:.||:....                        :|..|.|.|.|.      
Human   991 KACISEI--LPSKFKPRLSAPSA------------------------LLQEQKSVLLTS------ 1023

  Fly   735 DFYEYVAKELQELQDCGRLDEASSELIRNAPQTEDYSEILLQISRSLDNYSQQYIKEFVRRNRDE 799
                      ::.|.|..|..:.::..|..|         |::..|::|.       .:|..||.
Human  1024 ----------EKAQSCENLCVSLNDSKRGLP---------LRVGGSIENL-------LMRSRRDY 1062

  Fly   800 INKYEAELSEKEQQLAESTQKIADLDQK--------IMELEQQNRELLQQRTQQELELIQQKKLG 856
            .:|..:.:|  .|:.:.|:::...|.:|        ..::.|.||                  .|
Human  1063 DSKSSSTMS--LQEYSTSSRRPCPLSRKAGLHFSMFYRDMHQINR------------------AG 1107

  Fly   857 MTLNLTHTNGADDGEGTGEQAGLLLGTNRAGTLETCDTF---HTANSDCSFVSAL-----NTPAL 913
            ::|....::...|.....|::.|.|.....|..:.....   ||.:|..:....|     :.|:|
Human  1108 LSLGSISSSSVRDLASHFERSSLSLARGELGASQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSL 1172

  Fly   914 NSLNQL--IPTPSSTEDGTES---------DTGDRDYE-EAISNGGLLH----GGMSDSGVSFET 962
            :...:|  .|||..:..|..|         .|..|..| :.:.:||:..    ..|:|..:||.:
Human  1173 DFSGRLSKSPTPVLSRSGLTSARSAESLLESTKLRPREMDGMDSGGVYSSPTCSNMADHALSFRS 1237

  Fly   963 NRATDTAAALHTEADENESEGSVDRQSSGAASGTAKLLFQSD--DHCLLLATSSTPNPKYGGKKL 1025
            ...::..:....|.|...:..:..|:.||.:       ...|  .|.|.....:.| ..|     
Human  1238 LAPSEPLSICSDELDHCSNISNDSREGSGGS-------VHGDFPKHRLNKCKGTCP-ASY----- 1289

  Fly  1026 PTTTTTVIVTDGGGLLKSNQQQPQQSPRMRHKSSDSEEERTTITTMSSIGTPGSNRLKLSVPNRN 1090
             |..||:         :.::||..:.|..|   |||..:|.::.....:.:|...|||..:....
Human  1290 -TRFTTI---------RKHEQQSSRQPDWR---SDSRGDRNSLLRNIYLMSPLPFRLKKPLQQHP 1341

  Fly  1091 RSNSNNSKSSSMRTEIFDI--------RHG----IHPLRVSSVSSGTDGSHEEE----------- 1132
            |...::..|.....:..|:        .|.    :.|.|:||..:....||..|           
Human  1342 RQPPHDDSSGCPAGQKADLPCQGPQDQPHSAGKPMVPTRLSSRHTMARLSHNSEPPLDRSAGLED 1406

  Fly  1133 ------------------------EYEEEDAHG---------------------RRRHRQEVDDE 1152
                                    :.|...|||                     ||||    ||:
Human  1407 CTRAVNNGNPVPYSDHALDRNNNPQSELAAAHGDSESPRHFIPADYLESTEEFIRRRH----DDK 1467

  Fly  1153 EERRSRGSSIDNSSITSSTANLILCEMNHLRESIASKKAEIMK-----ILETNGDKKLLDGKIGE 1212
            |:                    :|.:...|:..  .::|:|..     ::.|: .:.:.:.:.|:
Human  1468 EK--------------------LLADQRRLKRE--QEEADIAARRHTGVIPTH-HQFITNERFGD 1509

  Fly  1213 L---QDLQKRIVQLEI---------KIQDVEKSCLSDGEL-----QLDSMRDIPESFTDSDDSRV 1260
            |   .|..||...||:         |.|.:::..|..|::     |:|.     ..:......||
Human  1510 LLNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQ-----NWYEGEHHGRV 1569

  Fly  1261 GNSCIYP------------------GYMRARDQGSIYAPSVTRSLPSIEGTYRSDHLINIPTYI- 1306
            |   |:|                  ..::..:.|...|.........:|.::|....|.:...: 
Human  1570 G---IFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 1631

  Fly  1307 -------IRGAGKQ-----------------THYEYEVKINLPDERWTLLRRYSRFRELHLTM-- 1345
                   |.|..:|                 |..:|   |:||         ||.......|:  
Human  1632 ENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDY---IDLP---------YSSSPSRSATVSP 1684

  Fly  1346 -----KKLYGDKIATIPFPRR----ELFASNTESVAKTRRRQLETYLRRLLVVCAKIPHCP---I 1398
                 .||.....:::|.|||    |:.|..:|.::.|    :....||.|.:...:|..|   :
Human  1685 QCTSHSKLIMPAPSSLPHPRRALSPEMHAITSEWISLT----VGVPGRRSLAMTPPLPPLPEASV 1745

  Fly  1399 YE-------GEGRPGL 1407
            |:       ...||.|
Human  1746 YDMDRLALSARARPSL 1761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpN58ANP_477384.1 MPP_superfamily 23..311 CDD:472684
PPP3CANP_000935.1 MPP_PP2B 41..345 CDD:277361
Catalytic. /evidence=ECO:0000305 56..340
SAPNY motif. /evidence=ECO:0000305|PubMed:26248042 307..311
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042 327..336
Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402 341..369
Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34 392..406
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 407..414
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402 465..487
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521
Blue background indicates that the domain is not in the aligned region.

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