DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpN58A and PPP1CB

DIOPT Version :9

Sequence 1:	NP_477384.1	Gene:	PpN58A / 37493	FlyBaseID:	FBgn0025573	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_002700.1	Gene:	PPP1CB / 5500	HGNCID:	9282	Length:	327	Species:	Homo sapiens

Alignment Length:	304	Identity:	187/304 - (61%)
Similarity:	243/304 - (79%)	Gaps:	10/304 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DEGINLDQIIAKLKLIGEI-----GSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDI 78
            |..:|:|.:|.:|.   |:     |.:||::..|:..:|.::||:.|.||.|||:.||:.:.|||
Human     3 DGELNVDSLITRLL---EVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDI 64

  Fly    79 HGQYLNLLRYFESNGYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSI 143
            ||||.:|||.||..|:||::.||.|||||||||||:||:.||||.|.:||..|:||||||||:||
Human    65 HGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI 129

  Fly   144 NHFYGFYDECKRRYTVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEI 208
            |..||||||||||:.:|||:||.||:||||:|||::|.||||||||||.|.||:|||.|.||.::
Human   130 NRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDV 194

  Fly   209 PESGLICDILWSDPDLRIMGWGPNERGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAK 273
            |::||:||:||||||..:.|||.|:||||.|||:||||.||:|..|:||||.|||||||||||||
Human   195 PDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAK 259

  Fly   274 RQLITIFSAPNYCGEFDNAGAMMCINQDLLCTFRVQRPILSEQR 317
            |||:|:||||||||||||||.||.:::.|:|:|::.:|  ||::
Human   260 RQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP--SEKK 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpN58A	NP_477384.1	PTZ00480	22..311	CDD:185658	183/293 (62%)
PpN58A	NP_477384.1	MPP_superfamily	23..311	CDD:301300	183/292 (63%)
PPP1CB	NP_002700.1	MPP_PP1_PPKL	7..297	CDD:277359	183/292 (63%)
PPP1CB	NP_002700.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D327461at33208
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760