DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpN58A and PPEF2

DIOPT Version :9

Sequence 1:	NP_477384.1	Gene:	PpN58A / 37493	FlyBaseID:	FBgn0025573	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_006230.2	Gene:	PPEF2 / 5470	HGNCID:	9244	Length:	753	Species:	Homo sapiens

Alignment Length:	383	Identity:	102/383 - (26%)
Similarity:	145/383 - (37%)	Gaps:	131/383 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QISVREIEAVCSRAREVLLKQPTLLEIPA----PINLLGDIHGQYLNLLRYFESNGYP-PDSVYL 101
            |:..|.:..:....::.|::.|.:..:..    .|.:.||:|||..:|:..|..||.| |:..|:
Human   140 QLHARYVLNLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYV 204

  Fly   102 LLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRYTV---KLWR 163
            ..||:|||||.|:|.|.:|.|....||.:|:|.|||||...:|..|||..|...:|.|   ::.|
Human   205 FNGDFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILR 269

  Fly   164 TFVDCYNCLPLAAIIEENIFCCHGGLS-----------------------PHLFSMQQIREIRR- 204
            |..|.:..||||.:|:|.:...|||:|                       ....|.:|:.|.||
Human   270 TLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRA 334

  Fly   205 ----------PIEIPES------------------------------------------------ 211
                      |..:|||
Human   335 NQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQVRSSVELELE 399

  Fly   212 ------GL---------------------------------ICDILWSDPDLRIMGWGPNE-RGV 236
                  ||                                 :.||||||| :...|...|. ||.
Human   400 RCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVDILWSDP-MAQEGCKANTIRGG 463

  Fly   237 SHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGA 294
            ...||.||....|.::.:..:.|.|:...:||||...|:::|||||.||.....|.||
Human   464 GCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASNYYEVGSNRGA 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpN58A	NP_477384.1	PTZ00480	22..311	CDD:185658	102/383 (27%)
PpN58A	NP_477384.1	MPP_superfamily	23..311	CDD:301300	102/383 (27%)
PPEF2	NP_006230.2	MPP_RdgC	122..537	CDD:277364	102/383 (27%)
		Catalytic	128..540		102/383 (27%)
		PP2Ac	141..540	CDD:197547	101/382 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..382		9/63 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..435		0/25 (0%)
		EFh	657..722	CDD:238008
		EF-hand_7	657..721	CDD:290234
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..753
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900