DRSC/TRiP Functional Genomics Resources

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Protein Alignment PpN58A and Ppp3ca

DIOPT Version :9

Sequence 1:NP_477384.1 Gene:PpN58A / 37493 FlyBaseID:FBgn0025573 Length:324 Species:Drosophila melanogaster
Sequence 2:NP_058737.1 Gene:Ppp3ca / 24674 RGDID:3382 Length:521 Species:Rattus norvegicus


Alignment Length:286 Identity:112/286 - (39%)
Similarity:161/286 - (56%) Gaps:25/286 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 IAKLKLIGEIGSVVQISVREIEAVCSRAREVLLKQPTLLEIPAPINLLGDIHGQYLNLLRYFESN 92
            |.|..|:.|......:::|    :.:....:|.::..||:|.||:.:.||||||:.:|::.||..
  Rat    45 ILKAHLMKEGRLEESVALR----IITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVG 105

  Fly    93 GYPPDSVYLLLGDYVDRGKQSIETLTLLLALKARYPTKFYLLRGNHECSSINHFYGFYDECKRRY 157
            |.|.::.||.||||||||..|||.:..|.|||..||...:||||||||..:..::.|..|||.:|
  Rat   106 GSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY 170

  Fly   158 TVKLWRTFVDCYNCLPLAAIIEENIFCCHGGLSPHLFSMQQIREIRRPIEIPESGLICDILWSDP 222
            :.:::...:|.::||||||::.:...|.||||||.:.::..||::.|..|.|..|.:||||||||
  Rat   171 SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDP 235

  Fly   223 DLRIMGWGPNE-----------RGVSHTFGSDVVSAFLHRFKLNLICRGHQVVEDGYEFFAKRQ- 275
             |...|   ||           ||.|:.:....|..||....|..|.|.|:..:.||..:.|.| 
  Rat   236 -LEDFG---NEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQT 296

  Fly   276 -----LITIFSAPNYCGEFDNAGAMM 296
                 ||||||||||...::|..|::
  Rat   297 TGFPSLITIFSAPNYLDVYNNKAAVL 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpN58ANP_477384.1 PTZ00480 22..311 CDD:185658 112/286 (39%)
MPP_superfamily 23..311 CDD:301300 112/286 (39%)
Ppp3caNP_058737.1 MPP_PP2B 41..345 CDD:277361 112/286 (39%)
Catalytic. /evidence=ECO:0000305 56..340 108/275 (39%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209 327..336
Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:Q08209 341..369
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:Q08209 392..406
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 407..414
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:1322410 465..487
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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